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公开(公告)号：US20110177526A1
公开(公告)日：2011-07-21
申请号：US13041204
申请日：2011-03-04
申请人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
发明人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
CPC分类号： C12N9/1205 , A61K48/00 , C07K16/40
摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。
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公开(公告)号：US07902348B2
公开(公告)日：2011-03-08
申请号：US12354668
申请日：2009-01-15
申请人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
发明人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
CPC分类号： C12N9/1205 , A61K48/00 , C07K16/40
摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。
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公开(公告)号：US07070972B1
公开(公告)日：2006-07-04
申请号：US08373934
申请日：1995-01-13
申请人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
发明人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
IPC分类号： C12N9/12 , C12N9/10 , C07K14/435
CPC分类号： C12N9/1205 , A61K48/00 , C07K16/40
摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
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公开(公告)号：US20090137787A1
公开(公告)日：2009-05-28
申请号：US12354668
申请日：2009-01-15
申请人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
发明人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
IPC分类号： C07H21/04
CPC分类号： C12N9/1205 , A61K48/00 , C07K16/40
摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。
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公开(公告)号：US07488808B2
公开(公告)日：2009-02-10
申请号：US11195197
申请日：2005-08-01
申请人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
发明人： John J. O'Shea , Warren J. Leonard , James A. Johnston , Sarah M. Russell , Daniel W. McVicar , Masaru Kawamura
CPC分类号： C12N9/1205 , A61K48/00 , C07K16/40
摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。
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