公开(公告)号：US07922646B2

公开(公告)日：2011-04-12

申请号：US10568728

申请日：2004-08-20

申请人： John L. Russell, Jr. ,  John L. Carden, Jr. ,  Roy Coniglione ,  Dominique Moyaux

发明人： John L. Russell, Jr. ,  John L. Carden, Jr. ,  Roy Coniglione ,  Dominique Moyaux

IPC分类号： A61N5/00

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

摘要： An implantable source (40) of therapeutic radiation for brachytherapy is provided as a sealed, biocompatible capsule (410) of plastic (e.g. polyethylene or PEEK) transparent to the radiation. The capsule contains a radiation source (400) comprising particles of a radioactive isotope (e.g. Pd103, I125, Cs131) in a fluid carrier that is resistant to radiation polymerization but solidifies at elevated temperature. It also has a marker (420), and desirably has a socket (430) which accommodates attaching spacers (660) and makes possible linear strands and planar arrays of the capsules. The spacers may be functional, e.g. heat-generating or medication-releasing.

摘要翻译： 提供用于近距离放射治疗的治疗辐射的可植入源（40）作为对辐射透明的塑料（例如聚乙烯或PEEK）的密封的生物相容性胶囊（410）。 胶囊包含辐射源（400），该辐射源包括在辐射聚合中耐受辐射聚合但在升高的温度下固化的流体载体中的放射性同位素（例如Pd103，I125，Cs131）的颗粒。 它还具有标记（420），并且期望地具有容纳附接间隔物（660）的插座（430），并且使胶囊的线性线束和平面阵列成为可能。 间隔物可以是有功能的。 发热或放药。

公开(公告)号：US06461433B1

公开(公告)日：2002-10-08

申请号：US09609834

申请日：2000-07-05

申请人： John L. Carden, Jr. ,  John L. Russell, Jr. ,  James Edward Fox ,  Alan Lionel Hudd ,  Michael Willis

发明人： John L. Carden, Jr. ,  John L. Russell, Jr. ,  James Edward Fox ,  Alan Lionel Hudd ,  Michael Willis

IPC分类号： B05C1100

CPC分类号： G21G4/08 ,  A61N5/1001 ,  A61N2005/1019

摘要： A method and apparatus for precisely applying radioactive material to a substrate such as a brachytherapy device is disclosed. A radioactive fluid adapted to cure rapidly is deposited as discrete dots onto a surface with a fluid-jet printhead. The apparatus comprises a fluid-jet printhead in communication with a chamber containing radioactive fluid to be applied by the printhead. The printhead is microprocessor driven, and the microprocessor may be provided with feedback from a station where the radioactivity deposited on a preceding substrate in a batch is measured, permitting the system to be recalibrated on an ongoing basis as the batch of printed devices is produced. Compensation for attenuation of radiation by a casing may also be made part of the feedback technique. Also disclosed is a brachytherapy device having printed on a surface dots of radiation-emitting material, in a pattern comprising various bands, dots or areas. Fluids suitable for printing by a fluid-jet printhead comprise a binder such as an acrylic resin or silicate, and a radioactive salt, compound or complex, dissolved in a radiation resistant solvent. Alternative fluids comprise radioactive salts, compounds, or complexes adsorbed onto a microparticulate carrier, or elemental microparticles, dispersed in a rapidly curable radiation-resistant fluid medium.

摘要翻译： 公开了一种用于将放射性材料精确地应用于诸如近距离放射治疗装置的基底的方法和装置。 适于快速固化的放射性流体用离散点沉积在具有流体喷射打印头的表面上。 该装置包括与包含要由打印头施加的放射性流体的室连通的流体喷射打印头。 打印头是微处理器驱动的，并且微处理器可以被提供有来自站的反馈，其中测量在批次中沉积在先前基板上的放射性，从而允许系统随着印刷设备的批次而在正在进行的基础上重新校准。 通过壳体对辐射的衰减的补偿也可以作为反馈技术的一部分。 还公开了以包括各种条带，点或区域的图案印刷在辐射发射材料的表面点上的近距离放射治疗装置。 适用于通过流体喷射印刷机印刷的流体包含溶解在耐辐射溶剂中的粘合剂，例如丙烯酸树脂或硅酸盐，以及放射性盐，化合物或络合物。 替代流体包括分散在快速固化的耐辐射流体介质中的微粒载体或元素微粒上的放射性盐，化合物或络合物。

公开(公告)号：US6086942A

公开(公告)日：2000-07-11

申请号：US85357

申请日：1998-05-27

申请人： John L. Carden, Jr. ,  John L. Russell, Jr. ,  James Edward Fox ,  Alan Lionel Hudd ,  Michael Willis

发明人： John L. Carden, Jr. ,  John L. Russell, Jr. ,  James Edward Fox ,  Alan Lionel Hudd ,  Michael Willis

IPC分类号： A61M36/12 ,  A61N5/10 ,  G21G4/08 ,  G21K5/02 ,  B05D1/42

CPC分类号： G21G4/08 ,  A61N2005/1019 ,  A61N5/1001

摘要： A method and apparatus for precisely applying radioactive material to a substrate such as a brachytherapy device is disclosed. A radioactive fluid adapted to cure rapidly is deposited as discrete dots onto a surface with a fluid-jet printhead. The apparatus comprises a fluid-jet printhead in communication with a chamber containing radioactive fluid to be applied by the printhead. The printhead is microprocessor driven, and the microprocessor may be provided with feedback from a station where the radioactivity deposited on a preceding substrate in a batch is measured, permitting the system to be recalibrated on an ongoing basis as the batch of printed devices is produced. Compensation for attenuation of radiation by a casing may also be made part of the feedback technique. Also disclosed is a brachytherapy device having printed on a surface dots of radiation-emitting material, in a pattern comprising various bands, dots or areas. Fluids suitable for printing by a fluid-jet printhead comprise a binder such as an acrylic resin or silicate, and a radioactive salt, compound or complex, dissolved in a radiation resistant solvent. Alternative fluids comprise radioactive salts, compounds, or complexes adsorbed onto a microparticulate carrier, or elemental microparticles, dispersed in a rapidly curable radiation-resistant fluid medium.

摘要翻译： 公开了一种用于将放射性材料精确地应用于诸如近距离放射治疗装置的基底的方法和装置。 适于快速固化的放射性流体用离散点沉积在具有流体喷射打印头的表面上。 该装置包括与包含要由打印头施加的放射性流体的室连通的流体喷射打印头。 打印头是微处理器驱动的，并且微处理器可以被提供有来自站的反馈，其中测量在批次中沉积在先前基板上的放射性，从而允许系统随着印刷设备的批次而在正在进行的基础上重新校准。 通过壳体对辐射的衰减的补偿也可以作为反馈技术的一部分。 还公开了以包括各种条带，点或区域的图案印刷在辐射发射材料的表面点上的近距离放射治疗装置。 适用于通过流体喷射打印机印刷的流体包含溶解在耐辐射溶剂中的粘合剂，例如丙烯酸树脂或硅酸盐，以及放射性盐，化合物或络合物。 替代流体包括分散在快速固化的耐辐射流体介质中的微粒载体或元素微粒上的放射性盐，化合物或络合物。

公开(公告)号：US5405309A

公开(公告)日：1995-04-11

申请号：US53422

申请日：1993-04-28

申请人： John L. Carden, Jr.

发明人： John L. Carden, Jr.

IPC分类号： A61M36/04 ,  A61K51/00 ,  A61M36/00 ,  A61M36/12 ,  A61N20060101 ,  A61N5/00 ,  A61N5/10 ,  G01N23/00

CPC分类号： A61N5/1027 ,  A61N2005/1024

摘要： Safe, isotopically pure Pd-103-containing seeds of high apparent activity are formed by bombarding an Rh target in a cyclotron with high energy particles to obtain Rh containing carrier-free Pd-103, separating therefrom the carrier-free Pd-103, adding a small amount of Pd to the carrier-free Pd-103, electroplating said Pd-103/Pd admixture to a pellet(s) of electroconductive material and encapsulating the pellet(s) within a bicompatible container or shell.

摘要翻译： 通过用高能粒子轰击回旋加速器中的Rh靶，形成具有高表观活性的安全，同位素纯的含Pd-103的种子，以获得含有载体的Pd-103，其中不含载体的Pd-103，添加 将少量的Pd与无载体Pd-103电镀，将所述Pd-103 / Pd混合物电镀到导电材料的颗粒上，并将颗粒封装在双相容的容器或壳体内。