METHOD AND SYSTEM FOR ANALYTE MONITORING USING SURFACE PLASMONS WITH A REFRESHABLE SURFACE
    1.
    发明申请
    METHOD AND SYSTEM FOR ANALYTE MONITORING USING SURFACE PLASMONS WITH A REFRESHABLE SURFACE 有权
    使用表面处理与可再热表面进行分析监测的方法和系统

    公开(公告)号:US20130017622A1

    公开(公告)日:2013-01-17

    申请号:US13500052

    申请日:2011-07-13

    申请人: John Richard Rahn

    发明人: John Richard Rahn

    IPC分类号: G01N21/55

    CPC分类号: G01N21/553

    摘要: The present technology provides an illustrative method for analyte monitoring using surface plasmons with a refreshable surface. The method includes placing a solution to be monitored in contact with a working surface of a surface plasmon resonance (SPR) generation system. The working surface includes a metal surface disposed on a glass surface, and the metal surface includes a first binding substance that provides binding sites for an analyte. The method further includes applying light to the metal surface at a plurality of angles over a period of time, measuring a reflectance of the light at each of the plurality of angles to determine an SPR angle, and monitoring changes to the SPR angle over the period of time. The working surface of the SPR generation system is refreshed by depositing a new layer of the first binding substance on the working surface of the SPR generation system.

    摘要翻译: 本技术提供了使用具有可刷新表面的表面等离子体激元进行分析物监测的说明性方法。 该方法包括将待监测的溶液放置在与表面等离子体共振(SPR)生成系统的工作表面接触的位置。 工作表面包括设置在玻璃表面上的金属表面,金属表面包括提供分析物结合位点的第一结合物质。 该方法还包括在一段时间内以多个角度向金属表面施加光,测量多个角度中的每个角度处的光的反射率以确定SPR角度,以及监视在该周期中的SPR角度的变化 的时间。 通过在SPR生成系统的工作表面上沉积第一结合物质的新层来更新SPR生成系统的工作表面。

    Method and system for analyte monitoring using surface plasmons with a refreshable surface
    3.
    发明授权
    Method and system for analyte monitoring using surface plasmons with a refreshable surface 有权
    使用具有可刷新表面的表面等离子体激元进行分析物监测的方法和系统

    公开(公告)号:US08507294B2

    公开(公告)日:2013-08-13

    申请号:US13500052

    申请日:2011-07-13

    申请人: John Richard Rahn

    发明人: John Richard Rahn

    IPC分类号: G01N21/55

    CPC分类号: G01N21/553

    摘要: The present technology provides an illustrative method for analyte monitoring using surface plasmons with a refreshable surface. The method includes placing a solution to be monitored in contact with a working surface of a surface plasmon resonance (SPR) generation system. The working surface includes a metal surface disposed on a glass surface, and the metal surface includes a first binding substance that provides binding sites for an analyte. The method further includes applying light to the metal surface at a plurality of angles over a period of time, measuring a reflectance of the light at each of the plurality of angles to determine an SPR angle, and monitoring changes to the SPR angle over the period of time. The working surface of the SPR generation system is refreshed by depositing a new layer of the first binding substance on the working surface of the SPR generation system.

    摘要翻译: 本技术提供了使用具有可刷新表面的表面等离子体激元进行分析物监测的说明性方法。 该方法包括将待监测的溶液放置在与表面等离子体共振(SPR)生成系统的工作表面接触的位置。 工作表面包括设置在玻璃表面上的金属表面,金属表面包括提供分析物结合位点的第一结合物质。 该方法还包括在一段时间内以多个角度向金属表面施加光,测量多个角度中的每个角度处的光的反射率以确定SPR角度,以及监视在该周期中的SPR角度的变化 的时间。 通过在SPR生成系统的工作表面上沉积第一结合物质的新层来更新SPR生成系统的工作表面。