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    Method for diagnosing melanocytic proliferations
    1.
    发明授权
    Method for diagnosing melanocytic proliferations 有权
    诊断黑素细胞增殖的方法

    公开(公告)号：US08859213B2

    公开(公告)日：2014-10-14

    申请号：US13642475

    申请日：2011-04-06

    申请人： Cynthia Magro ,  Jonathan Zippin ,  Lonny R. Levin ,  Jochen Buck

    发明人： Cynthia Magro ,  Jonathan Zippin ,  Lonny R. Levin ,  Jochen Buck

    IPC分类号： G01N33/53 ,  G01N33/574 ,  G01N33/50 ,  C12Q1/527 ,  G01N33/68

    CPC分类号： G01N33/5743 ,  C12Q1/527 ,  G01N33/5026 ,  G01N33/5044 ,  G01N33/5076 ,  G01N33/6893 ,  G01N2800/20 ,  G01N2800/56

    摘要： The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is complex, is discriminatory and distinctive according to the nature of the melanocytic proliferation. The sAC staining pattern comprises one or more of dot-like Golgi staining, broad granular Golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete granular nuclear staining, and pan-nuclear staining. The method of the invention is particularly useful in confirming or disaffirming a diagnosis reached through conventional histologic examination of a sample. Additionally, the invention provides a kit for use in interpreting melanocytic proliferations.

    摘要翻译： 本发明提供了用于诊断受试者中黑素细胞增殖的方法，其包括用针对可溶性腺苷酸环化酶（sAC）的抗体染色病变黑素细胞样品，并解释与诊断黑素细胞增殖相关的sAC染色模式。 根据黑素细胞增殖的性质，复杂的sAC染色模式具有歧视性和独特性。 sAC染色模式包括点状高尔基体染色，宽粒状高尔基体染色，弥漫性细胞质染色，核仁染色，不完全粒状核染色和泛核染色中的一种或多种。 本发明的方法特别可用于确认或不肯定通过常规的样品组织学检查达成的诊断。 另外，本发明提供了用于解释黑素细胞增殖的试剂盒。

    METHOD FOR DIAGNOSING MELANOCYTIC PROLIFERATIONS
    3.
    发明申请
    METHOD FOR DIAGNOSING MELANOCYTIC PROLIFERATIONS 有权
    用于诊断肌肉增生的方法

    公开(公告)号：US20130065246A1

    公开(公告)日：2013-03-14

    申请号：US13642475

    申请日：2011-04-06

    申请人： Cynthia Magro ,  Jonathan Zippin ,  Lonny R. Levin ,  Jochen Buck

    发明人： Cynthia Magro ,  Jonathan Zippin ,  Lonny R. Levin ,  Jochen Buck

    IPC分类号： G01N33/574 ,  G01N33/577

    CPC分类号： G01N33/5743 ,  C12Q1/527 ,  G01N33/5026 ,  G01N33/5044 ,  G01N33/5076 ,  G01N33/6893 ,  G01N2800/20 ,  G01N2800/56

    摘要： The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is complex, is discriminatory and distinctive according to the nature of the melanocytic proliferation. The sAC staining pattern comprises one or more of dot-like Golgi staining, broad granular Golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete granular nuclear staining, and pan-nuclear staining. The method of the invention is particularly useful in confirming or disaffirming a diagnosis reached through conventional histologic examination of a sample. Additionally, the invention provides a kit for use in interpreting melanocytic proliferations.

    摘要翻译： 本发明提供了一种用于诊断受试者中黑素细胞增殖的方法，包括用针对可溶性腺苷酸环化酶（sAC）的抗体染色病变黑素细胞样品，并解释与诊断黑素细胞增殖相关的sAC染色模式。 根据黑素细胞增殖的性质，复杂的sAC染色模式具有歧视性和独特性。 sAC染色模式包括点状高尔基体染色，宽粒状高尔基体染色，弥漫性细胞质染色，核仁染色，不完全粒状核染色和泛核染色中的一种或多种。 本发明的方法特别可用于确认或不肯定通过常规的样品组织学检查达成的诊断。 另外，本发明提供了用于解释黑素细胞增殖的试剂盒。