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公开(公告)号：US08859213B2
公开(公告)日：2014-10-14
申请号：US13642475
申请日：2011-04-06
申请人： Cynthia Magro , Jonathan Zippin , Lonny R. Levin , Jochen Buck
发明人： Cynthia Magro , Jonathan Zippin , Lonny R. Levin , Jochen Buck
IPC分类号： G01N33/53 , G01N33/574 , G01N33/50 , C12Q1/527 , G01N33/68
CPC分类号： G01N33/5743 , C12Q1/527 , G01N33/5026 , G01N33/5044 , G01N33/5076 , G01N33/6893 , G01N2800/20 , G01N2800/56
摘要： The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is complex, is discriminatory and distinctive according to the nature of the melanocytic proliferation. The sAC staining pattern comprises one or more of dot-like Golgi staining, broad granular Golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete granular nuclear staining, and pan-nuclear staining. The method of the invention is particularly useful in confirming or disaffirming a diagnosis reached through conventional histologic examination of a sample. Additionally, the invention provides a kit for use in interpreting melanocytic proliferations.
摘要翻译： 本发明提供了用于诊断受试者中黑素细胞增殖的方法，其包括用针对可溶性腺苷酸环化酶（sAC）的抗体染色病变黑素细胞样品，并解释与诊断黑素细胞增殖相关的sAC染色模式。 根据黑素细胞增殖的性质，复杂的sAC染色模式具有歧视性和独特性。 sAC染色模式包括点状高尔基体染色，宽粒状高尔基体染色，弥漫性细胞质染色，核仁染色，不完全粒状核染色和泛核染色中的一种或多种。 本发明的方法特别可用于确认或不肯定通过常规的样品组织学检查达成的诊断。 另外，本发明提供了用于解释黑素细胞增殖的试剂盒。
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公开(公告)号：US20130065246A1
公开(公告)日：2013-03-14
申请号：US13642475
申请日：2011-04-06
申请人： Cynthia Magro , Jonathan Zippin , Lonny R. Levin , Jochen Buck
发明人： Cynthia Magro , Jonathan Zippin , Lonny R. Levin , Jochen Buck
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/5743 , C12Q1/527 , G01N33/5026 , G01N33/5044 , G01N33/5076 , G01N33/6893 , G01N2800/20 , G01N2800/56
摘要： The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is complex, is discriminatory and distinctive according to the nature of the melanocytic proliferation. The sAC staining pattern comprises one or more of dot-like Golgi staining, broad granular Golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete granular nuclear staining, and pan-nuclear staining. The method of the invention is particularly useful in confirming or disaffirming a diagnosis reached through conventional histologic examination of a sample. Additionally, the invention provides a kit for use in interpreting melanocytic proliferations.
摘要翻译： 本发明提供了一种用于诊断受试者中黑素细胞增殖的方法，包括用针对可溶性腺苷酸环化酶（sAC）的抗体染色病变黑素细胞样品，并解释与诊断黑素细胞增殖相关的sAC染色模式。 根据黑素细胞增殖的性质，复杂的sAC染色模式具有歧视性和独特性。 sAC染色模式包括点状高尔基体染色，宽粒状高尔基体染色，弥漫性细胞质染色，核仁染色，不完全粒状核染色和泛核染色中的一种或多种。 本发明的方法特别可用于确认或不肯定通过常规的样品组织学检查达成的诊断。 另外，本发明提供了用于解释黑素细胞增殖的试剂盒。
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公开(公告)号：US06544768B1
公开(公告)日：2003-04-08
申请号：US09568407
申请日：2000-05-11
申请人： Jochen Buck , Lonny R. Levin
发明人： Jochen Buck , Lonny R. Levin
IPC分类号： C12N988
摘要： The invention provides isolated animal soluble adenylyl cyclase and methods of modulating its expression and activity. Also provided are methods of utilizing soluble adenylyl cyclase for diagnosing pathological conditions and monitoring blood gases.
摘要翻译： 本发明提供了分离的动物可溶性腺苷酸环化酶和调节其表达和活性的方法。 还提供了利用可溶性腺苷酸环化酶诊断病理状况和监测血液气体的方法。
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公开(公告)号：US09649295B2
公开(公告)日：2017-05-16
申请号：US10586929
申请日：2005-01-20
IPC分类号： A61K31/415 , A61K31/4184 , C12Q1/527
CPC分类号： A61K31/415 , A61K31/4184 , C12Q1/527 , G01N2333/988 , Y02A50/411
摘要： The present invention relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject. The method involves administering to a subject an effective amount of a compound disclosed herein that modulates soluble adenylyl cyclase, under conditions effective to treat the disorder mediated by soluble adenylyl cyclase. The present invention also relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject, where the disorder is selected from the group consisting of: learning or memory disorders, malaria, fungal infection, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, and peripheral neuropathy. The method involves modulating soluble adenylyl cyclase in the subject. Another aspect of the present invention relates to a method of modulating soluble adenylyl cyclase. The method involves contacting eukaryotic cells with a compound that modulates soluble adenylyl cyclase, under conditions effective to modulate soluble adenylyl cyclase.
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