-
公开(公告)号：US08825132B2
公开(公告)日：2014-09-02
申请号：US13541688
申请日：2012-07-04
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/282 , G01R33/445 , G01R33/485
摘要： An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.
摘要翻译： 在活的人体或动物体中，基质分子的超极化磁核的核磁共振实验涉及通过在低磁场中非氢化对氢诱导极化（= NH-PHIP）成单峰/伪单重态来使底物分子偏振， 将衬底分子注入生物体中，其主体或其一部分预先位于低磁场的磁体内。 磁体被接通到高磁场，并且在至少部分衬底分子中，单重态/伪单态态被转换成可观察的磁化。 用生物体或其部分进行MRI或MRS测量，从底物分子收集数据。 NMR实验非常适用于患者内的超极化核，由松弛过程引起的磁化损失减少。
-
2.发明授权MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material 有权MRI兼容方法和快速DNP在固态超极化样品中的装置公开(公告)号：US09329245B2
公开(公告)日：2016-05-03
申请号：US13443903
申请日：2012-04-11
申请人： Sami Jannin , Antonio Giuseppe Gianotti , Joost Lohman , Frank Engelke , Roberto Melzi , Aurélien Bornet , Geoffrey Bodenhausen
发明人： Sami Jannin , Antonio Giuseppe Gianotti , Joost Lohman , Frank Engelke , Roberto Melzi , Aurélien Bornet , Geoffrey Bodenhausen
CPC分类号： G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/62
摘要： A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high γ nuclei with a short T1, a polarizing agent with a broad EPR line, and low γ nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0≧4.0 T, thus polarizing the high γ nuclei by DNP, and the polarization is transferred from the high γ nuclei to the low γ nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low γ nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
摘要翻译： 用于制造用于磁共振研究的超极化样品材料的方法包括制备具有短T1的高γ核的目标材料，具有宽EPR线的偏振剂和具有长T1的低γ核。 用微波辐射照射目标材料中的偏振剂，其中目标材料处于低温并暴露于静态磁场B0≥4.0T，从而通过DNP使高γ核偏振，并且偏振从 通过交叉极化将高γ核转移到低γ核。 制备含有来自目标材料的超极化低γ核的溶解样品材料。 因此，具有长纵向弛豫时间T1的核可以快速超极化到高极化水平。
-
公开(公告)号：US20130274111A1
公开(公告)日：2013-10-17
申请号：US13443903
申请日：2012-04-11
申请人： Sami Jannin , Antonio Giuseppe Gianotti , Joost Lohman , Frank Engelke , Roberto Melzi , Aurélien Bornet , Geoffrey Bodenhausen
发明人： Sami Jannin , Antonio Giuseppe Gianotti , Joost Lohman , Frank Engelke , Roberto Melzi , Aurélien Bornet , Geoffrey Bodenhausen
CPC分类号： G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/62
摘要： A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high γ nuclei with a short T1, a polarizing agent with a broad EPR line, and low γ nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0≧4.0 T, thus polarizing the high γ nuclei by DNP, and the polarization is transferred from the high γ nuclei to the low γ nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low γ nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
摘要翻译： 用于生产用于磁共振研究的超极化样品材料的方法包括制备具有短T1的高γ核的靶材料，具有宽EPR线的偏振剂和具有长T1的低γ核。 目标材料中的偏振剂用微波辐射照射，其中目标材料处于低温并暴露于静态磁场B0> = 4.0T，从而通过DNP使高γ核偏振，并且偏振从 通过交叉极化对低伽马核的高伽马核。 制备溶解的样品材料，其包含来自靶材料的超极化低γ核。 因此，具有长纵向弛豫时间T1的核可以快速超极化到高极化水平。
-
公开(公告)号：US20140012129A1
公开(公告)日：2014-01-09
申请号：US13541688
申请日：2012-07-04
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/282 , G01R33/445 , G01R33/485
摘要： An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetisation. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.
摘要翻译： 在活的人体或动物体中，基质分子的超极化磁核的核磁共振实验涉及通过在低磁场中非氢化对氢诱导极化（= NH-PHIP）成单峰/伪单重态来使底物分子偏振， 将衬底分子注入生物体中，其主体或其一部分预先位于低磁场的磁体内。 磁体被接通到高磁场，并且在至少部分衬底分子中，单重态/伪单态态被转换成可观察到的磁化。 用生物体或其部分进行MRI或MRS测量，从底物分子收集数据。 NMR实验非常适用于患者内的超极化核，由松弛过程引起的磁化损失减少。
-
-
-
搜索结果
4 条记录 (耗时 0.01 秒)
