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公开(公告)号：US08766631B2
公开(公告)日：2014-07-01
申请号：US12998713
申请日：2009-11-27
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01R33/282 , G01R33/5605
摘要： The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.
摘要翻译： 本发明涉及一种用于制备和测量核自旋共振（NMR）测量样品（10）的装置（1,21,31,41,64），其包括流通的NMR探针头（2），其中具有 第一管（3）和第二管（14），每个用于供应和去除液体NMR测量样品（10）; - 至少一个室（4,22,32），其连接到管中的一个 ，14）， - 用于将所述液体测量样品（10）引入所述装置（1,21,31,41,64）中的样品入口（5），其中至少一个室（4,22,32）至少具有 一个用于增加（9,24,25,42,43,46,47）和释放（8,23,27,48a，48b）气体压力的连接，并且其中至少一个室（4,22,32） 包括用于将容纳在腔室（4,22,32）中的液体测量样品（10）与气体混合的装置利用本发明的装置，当对其中的液体测量样品进行NMR光谱测量时，可以减少测量样品消耗， 旋转 可以催化转移。
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2.发明授权公开(公告)号：US08154284B2
公开(公告)日：2012-04-10
申请号：US12452113
申请日：2008-06-17
IPC分类号： G01V3/00
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/282 , G01R33/4608 , G01R33/5605
摘要： An NMR method is presented having enhanced sensitivity on a compound comprising hyperpolarizable nuclei, in particular applying enhanced PHIP. Polarization is thereby transferred from a prepared fluid, which is enriched with symmetric molecules of a particular spin state (e.g. para-hydrogen enriched), directly to the hyperpolarizable nuclei of a compound, without altering the chemical identity of the compound in this process. Spin transfer is achieved using a template having sites of ordered environment, and the fluid and the compound are brought together in the presence of the template. Polarization transfer to the hyperpolarizable nuclei of the compound is thereby easier to perform and can be applied to a broader scope of compounds.
摘要翻译： 提出了对包含超极化核的化合物具有增强的灵敏度的NMR方法，特别是应用增强的PHIP。 因此，从制备的液体（其富含特定自旋状态的对称分子（例如富含氢的富集））直接转移到化合物的超极化核上，而不改变该方法中化合物的化学特性，从而转移极化。 使用具有有序环境位点的模板实现旋转转移，并且在模板存在下将流体和化合物合并在一起。 因此，化合物的超极化核的极化转移更容易进行并且可以应用于更广泛的化合物范围。
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3.发明申请公开(公告)号：US20100219826A1
公开(公告)日：2010-09-02
申请号：US12452113
申请日：2008-06-17
IPC分类号： G01R33/44
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/282 , G01R33/4608 , G01R33/5605
摘要： An NMR method is presented having enhanced sensitivity on a compound comprising hyperpolarizable nuclei, in particular applying enhanced PHIP. Polarization is thereby transferred from a prepared fluid, which is enriched with symmetric molecules of a particular spin state (e.g. para-hydrogen enriched), directly to the hyperpolarizable nuclei of a compound, without altering the chemical identity of the compound in this process. Spin transfer is achieved using a template having sites of ordered environment, and the fluid and the compound are brought together in the presence of the template. Polarization transfer to the hyperpolarizable nuclei of the compound is thereby easier to perform and can be applied to a broader scope of compounds.
摘要翻译： 提出了对包含超极化核的化合物具有增强的灵敏度的NMR方法，特别是应用增强的PHIP。 因此，从制备的液体（其富含特定自旋状态的对称分子（例如富含氢的富集））直接转移到化合物的超极化核上，而不改变该方法中化合物的化学特性，从而转移极化。 使用具有有序环境位点的模板实现旋转转移，并且在模板存在下将流体和化合物合并在一起。 因此，化合物的超极化核的极化转移更容易进行并且可以应用于更广泛的化合物范围。
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公开(公告)号：US20140012129A1
公开(公告)日：2014-01-09
申请号：US13541688
申请日：2012-07-04
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/282 , G01R33/445 , G01R33/485
摘要： An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetisation. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.
摘要翻译： 在活的人体或动物体中，基质分子的超极化磁核的核磁共振实验涉及通过在低磁场中非氢化对氢诱导极化（= NH-PHIP）成单峰/伪单重态来使底物分子偏振， 将衬底分子注入生物体中，其主体或其一部分预先位于低磁场的磁体内。 磁体被接通到高磁场，并且在至少部分衬底分子中，单重态/伪单态态被转换成可观察到的磁化。 用生物体或其部分进行MRI或MRS测量，从底物分子收集数据。 NMR实验非常适用于患者内的超极化核，由松弛过程引起的磁化损失减少。
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公开(公告)号：US20110285396A1
公开(公告)日：2011-11-24
申请号：US12998713
申请日：2009-11-27
IPC分类号： G01R33/44
CPC分类号： G01R33/307 , G01R33/282 , G01R33/5605
摘要： The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin reso nance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.
摘要翻译： 本发明涉及一种用于制备和测量核自旋电阻（NMR）测量样品（10）的装置（1,21,31,41,64），包括 - 流通的NMR探针头（2），具有 每个用于供应和去除液体NMR测量样品（10）的第一管（3）和第二管（14）; - 至少一个室（4,22,32），其连接到管中的一个 3，14）， - 用于将液体测量样品（10）引入到装置（1,21,31,41,64）中的样品入口（5），其中至少一个室（4,22,32）具有 至少一个用于增加（9,24,25,42,43,46,47）和释放（8,23,27,48a，48b）气体压力的连接，并且其中至少一个室（4,22,32 ）包括用于将容纳在腔室（4,22,32）中的液体测量样品（10）与气体混合的装置利用本发明的装置，当对液体测量样品进行NMR光谱测量时，可以减少测量样品消耗， 哪个spi n阶可以催化转移。
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公开(公告)号：US20110274626A1
公开(公告)日：2011-11-10
申请号：US13133867
申请日：2009-12-10
CPC分类号： G01R33/5601 , A61K49/10 , C07F15/0033 , C07F15/004 , G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/5607 , Y10T436/24
摘要： There is described a method of selective observation of non-hydrogenative para-hydrogen induced polarisation (NH-PHIP) as enhanced magnetic resonance signals which comprises separating the thermal and longitudinal spin order states. There is also described a template comprising [Ir(COD)(NHC)(Py)]+, and analogues thereof, for use in a PHIP magnetic resonance technique and a method for its preparation.
摘要翻译： 描述了选择性观察非氢化对氢诱导极化（NH-PHIP）作为增强磁共振信号的方法，其包括分离热和纵向旋转阶数状态。 还描述了用于PHIP磁共振技术的[Ir（COD）（NHC）（Py）] +及其类似物的模板及其制备方法。
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公开(公告)号：US08825132B2
公开(公告)日：2014-09-02
申请号：US13541688
申请日：2012-07-04
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/282 , G01R33/445 , G01R33/485
摘要： An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.
摘要翻译： 在活的人体或动物体中，基质分子的超极化磁核的核磁共振实验涉及通过在低磁场中非氢化对氢诱导极化（= NH-PHIP）成单峰/伪单重态来使底物分子偏振， 将衬底分子注入生物体中，其主体或其一部分预先位于低磁场的磁体内。 磁体被接通到高磁场，并且在至少部分衬底分子中，单重态/伪单态态被转换成可观察的磁化。 用生物体或其部分进行MRI或MRS测量，从底物分子收集数据。 NMR实验非常适用于患者内的超极化核，由松弛过程引起的磁化损失减少。
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