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1.发明申请Novel Chromen-2-One Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 有权新型色素-2-酮衍生物及其用作单胺神经递质重吸收抑制剂公开(公告)号：US20070232666A1
公开(公告)日：2007-10-04
申请号：US11661966
申请日：2005-09-28
IPC分类号： C07D451/06 , A61K31/137
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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2.发明申请Novel Alkyl Substituted Piperidine Derivatives as Monoamine Neurotransmitter Re-Uptake Inhibitors 审中-公开新型烷基取代的哌啶衍生物作为单胺神经递质重吸收抑制剂公开(公告)号：US20070232659A1
公开(公告)日：2007-10-04
申请号：US11579059
申请日：2005-06-14
IPC分类号： A61K31/454 , A61P15/00 , A61P25/00 , C07D401/06
CPC分类号： C07D401/12 , C07D401/04 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2007/10/04/US20070232641A1/abs.jpg.150x150.jpg)
3.发明申请Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 失效新型9-氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20070232641A1
公开(公告)日：2007-10-04
申请号：US11579056
申请日：2005-06-14
IPC分类号： C07D451/14 , A61K31/439 , A61P23/00
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2008/01/03/US20080004252A1/abs.jpg.150x150.jpg)
4.发明申请3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors 失效3,8-取代的8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单体神经递质重吸收抑制剂的用途公开(公告)号：US20080004252A1
公开(公告)日：2008-01-03
申请号：US11794365
申请日：2006-01-11
申请人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
发明人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
IPC分类号： A61K31/397 , A61P25/00 , C07D205/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2006/06/29/US20060142331A1/abs.jpg.150x150.jpg)
5.发明申请Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权新型8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060142331A1
公开(公告)日：2006-06-29
申请号：US10561417
申请日：2004-06-18
IPC分类号： C07D451/06 , A61K31/46
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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6.发明申请Novel alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效新型烷基取代的哌啶衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20070167487A1
公开(公告)日：2007-07-19
申请号：US11579060
申请日：2005-06-14
IPC分类号： A61K31/445 , C07D211/06 , C07D211/54
CPC分类号： C07D211/42 , C07D211/46 , C07D211/54 , C07D211/58
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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7.发明申请8-Aza-Bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环（3.2.1）辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060122218A1
公开(公告)日：2006-06-08
申请号：US10544027
申请日：2004-02-10
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2006/07/06/US20060148847A1/abs.jpg.150x150.jpg)
8.发明申请Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效新型8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060148847A1
公开(公告)日：2006-07-06
申请号：US10543828
申请日：2004-02-10
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclo[[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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9.发明申请Novel Naphthyl Substituted Azabicyclo Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors 失效新型萘基取代的氮杂双环衍生物及其作为单体神经递质重吸收抑制剂公开(公告)号：US20070287728A1
公开(公告)日：2007-12-13
申请号：US11667316
申请日：2005-12-16
申请人： Dan Peters , Gunnar Olsen , Elsebet Nielsen
发明人： Dan Peters , Gunnar Olsen , Elsebet Nielsen
IPC分类号： A61K31/439 , A61P13/00 , A61P15/00 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P3/04 , C07D453/02
CPC分类号： C07D453/02
摘要： This invention relates to novel naphthyl substituted azabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新的萘基取代的氮杂二环衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US20070299082A1
公开(公告)日：2007-12-27
申请号：US11663152
申请日：2005-10-14
申请人： Dan Peters , Daniel Timmermann , Gunnar Olsen , Elsebet Nielsen , Tino Jorgensen
发明人： Dan Peters , Daniel Timmermann , Gunnar Olsen , Elsebet Nielsen , Tino Jorgensen
IPC分类号： A61K31/439 , A61K31/501 , A61P25/18 , C07D401/02 , C07D401/14 , C07D453/02
CPC分类号： C07D453/02
摘要： This invention relates to novel azabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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