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    BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
    4.
    发明申请
    BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS 审中-公开
    作为用于治疗E.G.的钾通道调节剂的苯并噻唑衍生物 呼吸系统疾病，癫痫和痉挛

    公开(公告)号：US20100168192A1

    公开(公告)日：2010-07-01

    申请号：US12601482

    申请日：2008-05-22

    申请人： Antonio Nardi ,  Claus Mathiesen ,  Jeppe Kejser Christensen

    发明人： Antonio Nardi ,  Claus Mathiesen ,  Jeppe Kejser Christensen

    IPC分类号： A61K31/423 ,  C07D261/20 ,  A61P11/00 ,  A61P25/00 ,  A61P25/08 ,  A61P13/00 ,  A61P15/00 ,  A61P1/00 ,  A61P9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61P27/00

    CPC分类号： C07D261/20

    摘要： This invention relates to novel benzisoxazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels e.g. a respiratory disease, epilepsy or convulsions. X represents a substituent selected from the group consisting of CO—NR′R″, CO—O—R′, CO—NH—S, CO—NH—SO2R″′, CO—NH—C═N, SO2—NR′R″, 2,3-dihydro-1-H-tetrazol-5-yl and [1,2,4]oxadiazolidin-5-one; wherein R′ and R″, independently of each other, represent hydrogen or alkyl or phenyl; and R″′ represents alkyl, cycloalkyl, haloalkyl or phenyl, which phenyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano and nitro.

    摘要翻译： 本发明涉及被发现是钾通道的有效调节剂的新的苯并异恶唑衍生物，因此是治疗与钾通道调节有关的疾病或病症多种多样的有价值的候选物。 呼吸系统疾病，癫痫或惊厥。 X表示选自CO-NR'R“，CO-O-R'，CO-NH-S，CO-NH-SO2R”'，CO-NH-C = N，SO2-NR' R“，2,3-二氢-1-H-四唑-5-基和[1,2,4]恶二唑烷-5-酮; 其中R'和R“彼此独立地表示氢或烷基或苯基; 并且R“'表示烷基，环烷基，卤代烷基或苯基，该苯基可以任选被一个或多个取代基取代，所述取代基选自卤素，三氟甲基，三氟甲氧基，氰基和硝基。