公开(公告)号：US20140170125A1

公开(公告)日：2014-06-19

申请号：US14238082

申请日：2012-08-10

申请人： Begoña García Cenador ,  Javier García Criado ,  Francisco Javier López Hernández ,  Jose Miguel López Novoa ,  Maria Pilar Perez De Obanos Martell ,  Juan Ruiz Echeverría

发明人： Begoña García Cenador ,  Javier García Criado ,  Francisco Javier López Hernández ,  Jose Miguel López Novoa ,  Maria Pilar Perez De Obanos Martell ,  Juan Ruiz Echeverría

IPC分类号： A61K38/22 ,  A61K33/24 ,  C07K14/52 ,  A61K31/7036

CPC分类号： A61K38/22 ,  A61K31/7036 ,  A61K33/24 ,  A61K38/19 ,  C07K14/52

摘要： The present invention relates to the use of cardiotrophin-1 (CT-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1.

摘要翻译： 本发明涉及心肌营养因子-1（CT-1）用于预防和/或治疗急性肾损伤的用途，特别是由肾毒性剂如造影剂，抗生素，免疫抑制剂或抗肿瘤剂引起的急性肾损伤 。 本发明还涉及包含所述肾毒性剂和心肌营养素-1的组合物。

公开(公告)号：US09049856B2

公开(公告)日：2015-06-09

申请号：US13699792

申请日：2011-05-24

申请人： Haisul C.Y. Chang ,  Victor Fernández Gallego ,  María Iñiguez Martínez ,  Jose Miguel López Novoa ,  Jesús María Prieto Valtueña ,  Juan Ruiz Echeverría

发明人： Haisul C.Y. Chang ,  Victor Fernández Gallego ,  María Iñiguez Martínez ,  Jose Miguel López Novoa ,  Jesús María Prieto Valtueña ,  Juan Ruiz Echeverría

IPC分类号： A01N1/00 ,  A01N1/02

CPC分类号： A01N1/0221 ,  A01N1/0226

摘要： The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.

摘要翻译： 本发明涉及一种用于移植的冷器官保存组合物，其包含冷器官保存液和心肌营养素-1或其功能等价变体。 本发明还涉及用于制备所述组合物的方法和试剂盒，其用于冷器官保护和/或移植保存（特别是肾，肺和心脏）的用途，以及冷保存方法和冷保存的分离物 器官通过这些方法。