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公开(公告)号：US20130130225A1
公开(公告)日：2013-05-23
申请号：US13699792
申请日：2011-05-24
申请人： Haisul C.Y. Chang , Victor Fernández Gallego , María Iñiguez Martínez , Jose Miguel Lopez Novoa , Jesús María Prieto Valtueña , Juan Ruiz Echeverría
发明人： Haisul C.Y. Chang , Victor Fernández Gallego , María Iñiguez Martínez , Jose Miguel Lopez Novoa , Jesús María Prieto Valtueña , Juan Ruiz Echeverría
IPC分类号： A01N1/02
CPC分类号： A01N1/0221 , A01N1/0226
摘要： The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.
摘要翻译： 本发明涉及一种用于移植的冷器官保存组合物，其包含冷器官保存液和心肌营养素-1或其功能等价变体。 本发明还涉及用于制备所述组合物的方法和试剂盒，其用于冷器官保护和/或移植保存（特别是肾，肺和心脏）的用途，以及冷保存方法和冷保存的分离物 器官通过这些方法。
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公开(公告)号：US09049856B2
公开(公告)日：2015-06-09
申请号：US13699792
申请日：2011-05-24
申请人： Haisul C.Y. Chang , Victor Fernández Gallego , María Iñiguez Martínez , Jose Miguel López Novoa , Jesús María Prieto Valtueña , Juan Ruiz Echeverría
发明人： Haisul C.Y. Chang , Victor Fernández Gallego , María Iñiguez Martínez , Jose Miguel López Novoa , Jesús María Prieto Valtueña , Juan Ruiz Echeverría
CPC分类号： A01N1/0221 , A01N1/0226
摘要： The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.
摘要翻译： 本发明涉及一种用于移植的冷器官保存组合物，其包含冷器官保存液和心肌营养素-1或其功能等价变体。 本发明还涉及用于制备所述组合物的方法和试剂盒，其用于冷器官保护和/或移植保存（特别是肾，肺和心脏）的用途，以及冷保存方法和冷保存的分离物 器官通过这些方法。
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公开(公告)号：US20110081718A1
公开(公告)日：2011-04-07
申请号：US12996346
申请日：2009-06-01
IPC分类号： C12N15/63
CPC分类号： C12N15/86 , C07K2319/09 , C07K2319/715 , C07K2319/80 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2800/30 , C12N2800/40 , C12N2800/80 , C12N2830/001 , C12N2840/20
摘要： The invention relates to a nuew system for production and packaging of high capacity adenoviral vectors which does not require the use of helper virues and which is characterized in that it integrates the adenoviral genes needed for the control, replication and packaging of the viral particuiles in the genome of a host cell, which results in the improvement of the long term stability of the production system.
摘要翻译： 本发明涉及用于生产和包装大容量腺病毒载体的微珠系统，其不需要使用辅助病毒颗粒，其特征在于将病毒微粒子的控制，复制和包装所需的腺病毒基因整合到 宿主细胞的基因组，这导致生产系统的长期稳定性的改善。
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公开(公告)号：US20120225933A1
公开(公告)日：2012-09-06
申请号：US13508494
申请日：2010-11-04
IPC分类号： A61K31/713 , C12N15/86 , A61P35/00 , C12N15/113 , A61P1/16 , C12N15/85 , C12N5/10
CPC分类号： C12N15/635 , C12N2799/025 , C12N2830/003 , C12N2830/008
摘要： The application relates to gene constructs for inducible hepato-specific expression of polynucleotides of interest in response to an inducer agent, said constructs comprising (i) an inducible bi-directional operator-promoter with at least one responsive element to said inducer agent flanked by two hepato-specific promoters acting in divergent manner, (ii) a first nucleotide sequence encoding a transactivator which may be activated by said inducer agent operatively coupled to the first hepato-specific promoter and (iii) a second nucleotide sequence operatively coupled to the second hepato-specific promoter, wherein the promoters are induced as a consequence of the binding of the transactivator to the operator region of the operator-promoter in the presence of the inducer agent.
摘要翻译： 本申请涉及用于诱导型肝细胞特异性表达感兴趣的多核苷酸的基因构建体，所述基因构建体响应于诱导剂，所述构建体包含（i）具有至少一个对所述诱导剂的响应元件的诱导型双向操纵子启动子， （ii）编码反式激活因子的第一核苷酸序列，其可被所述诱导剂活化，所述诱导剂与第一肝特异性启动子有效偶联，和（iii）可操作地偶联至第二肝细胞的第二核苷酸序列 特异性启动子，其中由诱导剂存在下反式激活因子与操纵子启动子的操纵子区域的结合而诱导启动子。
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公开(公告)号：US20110268757A1
公开(公告)日：2011-11-03
申请号：US13132530
申请日：2009-12-02
申请人： Francisco Borrás Cuesta , Inés Noelia Casares Lagar , María del Carmen Durántez Delgado , Juan José Lasarte Sagastibelza , Claude Leclerc , Jesús María Prieto Valtueña , Pablo Sarobe Ugarriza
发明人： Francisco Borrás Cuesta , Inés Noelia Casares Lagar , María del Carmen Durántez Delgado , Juan José Lasarte Sagastibelza , Claude Leclerc , Jesús María Prieto Valtueña , Pablo Sarobe Ugarriza
CPC分类号： C07K14/31 , A61K39/385 , A61K2039/55561 , A61K2039/6068 , C07K14/47 , C07K2319/00
摘要： The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSMα, PSMγ and PSMδ peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSMα, PSMγ and PSMδ peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer
摘要翻译： 本发明涉及通过其与调节蛋白衍生肽（PSM，苯酚可溶性调节素）的共价偶联增加抗原肽的免疫原性的方法。 特别地，PSMα，PSMγ和PSMδ肽与抗原（来自病原体或肿瘤相关蛋白）的结合增加了抗原在体内激活免疫应答的能力。 因此，与这些抗原结合的PSMα，PSMγ和PSMδ肽可用于开发用于预防或治疗感染性疾病或癌症的疫苗
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