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公开(公告)号：US20090324649A1
公开(公告)日：2009-12-31
申请号：US12436398
申请日：2009-05-06
IPC分类号： A61K39/008 , C12N15/63 , G01N33/53 , C07H21/04 , C07K14/00 , C07K16/00 , C12N1/21 , C12N1/19 , C12N5/10
CPC分类号： C07K14/43577 , A61K39/00 , A61K39/0003 , A61K45/06 , A61K2039/53 , A61K2039/58 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供了在体内或体外沙蝇Lu中含有和表达的载体。 在动物或人类针对利什曼原虫引起免疫应答的长叶螨唾液抗原，包含所述载体和/或Lu的疫苗组合物。 长叶is鱼唾液多肽，针对利什曼原虫疫苗的方法，以及用于这些方法和组合物的试剂盒。
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公开(公告)号：US20060179561A1
公开(公告)日：2006-08-17
申请号：US10549422
申请日：2004-03-17
申请人： Jose Ribeiro
发明人： Jose Ribeiro
IPC分类号： E04H4/00
CPC分类号： E04H4/0043
摘要： Modular pool constructive design whose walls are constituted by metallic panels (17, 18, 19), made up by folding metallic sheets, comprising a bottom including a structure that supports a plurality of metallic panels-tiles (16)—said walls (11, 12, 13, 14) are connected to said bottom's structure, making up a unique and non-deformable structure, all the pool's elements are interlinked by semi-permanent connecting means, such as screws and nuts. The dimensions of the pool's elements allow its easy transport in small vehicles or buildings' elevators.
摘要翻译： 模块化池结构设计，其壁由金属板（17,18,19）构成，金属板由折叠金属板构成，包括底部，该底部包括支撑多个金属板的结构 - 砖（16） - 壁（11， 12,13,14）连接到所述底部结构，构成一个独特且不可变形的结构，所有的池的元件都通过诸如螺钉和螺母的半永久连接装置相互连接。 游泳池元素的尺寸允许在小型车辆或建筑物的电梯中轻松运输。
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公开(公告)号：US08603808B2
公开(公告)日：2013-12-10
申请号：US12436398
申请日：2009-05-06
CPC分类号： C07K14/43577 , A61K39/00 , A61K39/0003 , A61K45/06 , A61K2039/53 , A61K2039/58 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供了在体内或体外沙蝇Lu中含有和表达的载体。 在动物或人类针对利什曼原虫引起免疫应答的长叶螨唾液抗原，包含所述载体和/或Lu的疫苗组合物。 长叶is鱼唾液多肽，针对利什曼原虫疫苗的方法，以及用于这些方法和组合物的试剂盒。
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公开(公告)号：US20060051364A1
公开(公告)日：2006-03-09
申请号：US10533811
申请日：2003-10-29
申请人： Jesus Valenzuela , Jose Ribeiro , Aldina Barral , Manoel Netto , Claudia Brodskyn , Regis Gomes
发明人： Jesus Valenzuela , Jose Ribeiro , Aldina Barral , Manoel Netto , Claudia Brodskyn , Regis Gomes
IPC分类号： A61K39/02
CPC分类号： A61K39/008 , A61K38/00 , A61K39/0003 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/58 , C07K14/43577 , C07K14/44 , C07K16/18 , C07K16/20 , C07K2317/21 , C12N15/63 , Y02A50/41
摘要： Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
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公开(公告)号：US09228002B2
公开(公告)日：2016-01-05
申请号：US14069406
申请日：2013-11-01
IPC分类号： A61K39/00 , C07K14/435 , A61K45/06
CPC分类号： C07K14/43577 , A61K39/00 , A61K39/0003 , A61K45/06 , A61K2039/53 , A61K2039/58 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
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公开(公告)号：US20140294875A1
公开(公告)日：2014-10-02
申请号：US14069406
申请日：2013-11-01
IPC分类号： C07K14/435 , A61K45/06 , A61K39/00
CPC分类号： C07K14/43577 , A61K39/00 , A61K39/0003 , A61K45/06 , A61K2039/53 , A61K2039/58 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供了在体内或体外沙蝇Lu中含有和表达的载体。 在动物或人类针对利什曼原虫引起免疫应答的长叶螨唾液抗原，包含所述载体和/或Lu的疫苗组合物。 长叶is鱼唾液多肽，针对利什曼原虫疫苗的方法，以及用于这些方法和组合物的试剂盒。
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