Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion Animals
    1.
    发明申请
    Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion Animals 有权
    Her2 DNA疫苗作为伴侣动物癌症的辅助治疗

    公开(公告)号:US20120093841A1

    公开(公告)日:2012-04-19

    申请号:US13272651

    申请日:2011-10-13

    摘要: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

    摘要翻译: 该申请公开了基于表达编码大鼠Her2蛋白的基因的“pING”DNA质粒载体的治疗性疫苗。 根据本公开的疫苗被用作用于具有过表达Her2抗原的癌症的狗和猫的手术,放射和/或化学疗法的辅助治疗,并且延长了手术后无疾病间隔和/或存活时间。 还包括使用所述疫苗的治疗有效的免疫方法。

    INTRA-VASCULAR KIDNEY GENE THERAPY WITH PLASMID ENCODING BMP-7
    2.
    发明申请
    INTRA-VASCULAR KIDNEY GENE THERAPY WITH PLASMID ENCODING BMP-7 有权
    血管内皮生长因子基因治疗用等离子体编码BMP-7

    公开(公告)号:US20100261782A1

    公开(公告)日:2010-10-14

    申请号:US12794184

    申请日:2010-06-04

    IPC分类号: A61K48/00 C12N15/63 A61P13/12

    摘要: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.

    摘要翻译: 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过血管内肾脏给予本发明的重组载体和药物组合物来预防和/或治疗哺乳动物,有利地在人,狗和猫中的急性和慢性肾功能衰竭的方法。

    CANINE LEISHMANIA VACCINE
    3.
    发明申请

    公开(公告)号:US20080241193A1

    公开(公告)日:2008-10-02

    申请号:US11942457

    申请日:2007-11-19

    IPC分类号: A61K39/00 C12N15/00 A61P37/00

    摘要: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

    摘要翻译: 本发明提供含有体内利什曼原虫KMP11或其表位的载体,其在狗中针对利什曼原虫引起免疫应答,包含所述载体的组合物,针对利什曼原虫接种的方法,以及用于此类方法和组合物的试剂盒。

    Canine leishmania vaccine
    5.
    发明授权
    Canine leishmania vaccine 有权
    犬利什曼原虫疫苗

    公开(公告)号:US08871225B2

    公开(公告)日:2014-10-28

    申请号:US12839580

    申请日:2010-07-20

    摘要: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

    摘要翻译: 本发明提供含有体内利什曼原虫KMP11或其表位的载体,其在狗中针对利什曼原虫引起免疫应答,包含所述载体的组合物,针对利什曼原虫接种的方法,以及用于此类方法和组合物的试剂盒。

    Canine Leishmania vaccine
    8.
    发明授权
    Canine Leishmania vaccine 有权
    犬利什曼原虫疫苗

    公开(公告)号:US07794736B2

    公开(公告)日:2010-09-14

    申请号:US11942457

    申请日:2007-11-19

    IPC分类号: A61K39/00

    摘要: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

    摘要翻译: 本发明提供含有体内利什曼原虫KMP11或其表位的载体,其在狗中针对利什曼原虫引起免疫应答,包含所述载体的组合物,针对利什曼原虫疫苗接种的方法,以及用于此类方法和组合物的试剂盒。

    Plasmid encoding human BMP-7
    9.
    发明授权
    Plasmid encoding human BMP-7 有权
    编码人BMP-7的质粒

    公开(公告)号:US07771995B2

    公开(公告)日:2010-08-10

    申请号:US11803991

    申请日:2007-05-16

    IPC分类号: C12N15/00 C07H21/02

    摘要: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.

    摘要翻译: 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过血管内肾脏给予本发明的重组载体和药物组合物来预防和/或治疗哺乳动物,有利地在人,狗和猫中的急性和慢性肾功能衰竭的方法。