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    PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF
    2.
    发明申请
    PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF 有权
    蛋白质结合域稳定功能性GPCRS的功能状态及其用途

    公开(公告)号：US20130183287A1

    公开(公告)日：2013-07-18

    申请号：US13810652

    申请日：2011-07-18

    申请人： Jan Steyaert ,  Els Pardon ,  Soren Rasmussen ,  Juan Fung ,  Brian Kobilka ,  Toon Laeremans

    发明人： Jan Steyaert ,  Els Pardon ,  Soren Rasmussen ,  Juan Fung ,  Brian Kobilka ,  Toon Laeremans

    IPC分类号： C07K14/705

    CPC分类号： G01N33/6872 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K2317/22 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/75 ,  G01N23/20 ,  G01N33/566 ,  G01N33/68 ,  G01N33/6857 ,  G01N2333/726

    摘要： The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, it provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains hereof can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, also encompassed are the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

    摘要翻译： 本公开涉及GPCR结构生物学和信号传导领域。 特别地，其涉及针对或能够特异性结合G蛋白偶联受体（GPCR）的功能构象状态的蛋白质结合结构域。 更具体地，其提供能够增加GPCR的功能构象状态的稳定性的蛋白质结合结构域，特别是增加GPCR在其活性构象状态下的稳定性。 本文的蛋白结合结构域可用作结合和功能表征与各种天然和合成配体结合的G蛋白偶联受体的工具，以及针对GPCRs的筛选和药物发现工作。 此外，还包括这些蛋白结合结构域对于GPCR相关疾病的诊断，预后和治疗有用性。

    PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF
    3.
    发明申请
    PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF 审中-公开
    蛋白质结合域稳定功能性GPCRS的功能状态及其用途

    公开(公告)号：US20130137856A1

    公开(公告)日：2013-05-30

    申请号：US13810657

    申请日：2011-07-18

    申请人： Jan Steyaert ,  Els Pardon ,  Toon Laeremans ,  Søren Rasmussen ,  Brian Kobilka ,  Juan Fung

    发明人： Jan Steyaert ,  Els Pardon ,  Toon Laeremans ,  Søren Rasmussen ,  Brian Kobilka ,  Juan Fung

    IPC分类号： G01N33/68

    摘要： The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

    摘要翻译： 本发明涉及GPCR结构生物学和信号传导领域。 特别地，本发明涉及针对或能够特异性结合G蛋白偶联受体（GPCR）的功能构象状态的蛋白质结合结构域。 更具体地，本发明提供能够增加GPCR的功能构象状态的稳定性的蛋白质结合结构域，特别是提高GPCR在其活性构象状态下的稳定性。 本发明的蛋白质结合结构域可用作结合和功能表征与各种天然和合成配体结合的G蛋白偶联受体的工具，以及靶向GPCR的筛选和药物发现工作。 此外，本发明还包括这些蛋白结合结构域对GPCR相关疾病的诊断，预后和治疗有用性。