Hydroxymethylation of tocopherols
    3.
    发明授权
    Hydroxymethylation of tocopherols 失效
    生育酚的羟甲基化

    公开(公告)号:US5892058A

    公开(公告)日:1999-04-06

    申请号:US848041

    申请日:1997-04-28

    CPC分类号: C07D311/72 Y02P20/582

    摘要: A method of producing .alpha.-tocopherol from non-.alpha.-tocopherols is disclosed. In the disclosed method, non-.alpha.-tocopherols are hydroxymethylated and reduced to .alpha.-tocopherol in a single step by reacting formaldehyde or a formaldehyde-producing compound with the non-.alpha.-tocopherol under catalytic reducing conditions in a reaction mixture containing the non-.alpha.-tocopherol, formaldehyde or formaldehyde-producing compound and boric acid or a boric acid-producing compound dispersed in a solvent of an azeotropic mixture of trimethyl borate and methanol and a non-polar organic solvent.

    摘要翻译: 公开了一种从非α-生育酚生产α-生育酚的方法。 在所公开的方法中,非α-生育酚被羟甲基化并在一个步骤中通过使甲醛或产生甲醛的化合物与非α-生育酚在催化还原条件下在含有非α-生育酚的反应混合物中反应而被还原成α-生育酚, α-生育酚,甲醛或生产甲醛的化合物和分散在硼酸三甲酯和甲醇和非极性有机溶剂的共沸混合物的溶剂中的硼酸或硼酸生成化合物。