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    Biocompatible coating for a prosthesis and a method of forming the same
    4.
    发明授权
    Biocompatible coating for a prosthesis and a method of forming the same 有权
    用于假体的生物相容性涂层及其形成方法

    公开(公告)号：US06713119B2

    公开(公告)日：2004-03-30

    申请号：US09470559

    申请日：1999-12-23

    申请人： Syed F. A. Hossainy ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daniel A. Castro ,  Sameer Harish ,  Steven Z. Wu

    发明人： Syed F. A. Hossainy ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daniel A. Castro ,  Sameer Harish ,  Steven Z. Wu

    IPC分类号： A61F202

    CPC分类号： A61L33/0011 ,  A61F2/91 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  C08L29/04

    摘要： A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.

    摘要翻译： 公开了一种用于假体的涂层，例如支架和用于形成涂层的组合物。 该涂层可用作底漆，允许诸如聚合物的物质被假体有效地固定。 或者，涂层可以用作储存器，允许治疗物质局部和持续释放到生物组织。 组合物可以由乙烯乙烯醇共聚物和二甲基亚砜溶剂形成，具有或不具有治疗物质。 或者，组合物可以由乙烯乙烯醇共聚物，二甲基亚砜溶剂和润湿流体形成，具有或不具有治疗物质。 将组合物施加到假体的表面，并且基本上所有的二甲基亚砜溶剂或二甲基亚砜溶剂/润湿流体被除去或允许蒸发以形成涂层。