摘要:
The present invention relates to the sequence of guinea pig chymase. Since guinea pigs express only one chymase isoform, they are particularly suitable as a model for a method for identifying compounds that modulate chymase.
摘要:
A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.
摘要翻译:脂质颗粒,其包含载脂蛋白,磷脂酰胆碱和脂质,例如磷脂,脂肪酸或类固醇脂质。 在一个实施方案中,脂质颗粒仅包含一种载脂蛋白。 在一个实施方案中,脂质颗粒由一种载脂蛋白,磷脂,脂质和洗涤剂组成。 在一个实施方案中,脂质是第二磷脂酰胆碱,其中第一磷脂酰胆碱和第二磷脂酰胆碱在一个或两个脂肪酸残基或被酯化成磷脂酰胆碱的甘油骨架的脂肪酸残基衍生物不同。 在一个实施方案中,载脂蛋白选自具有选自SEQ ID NO:01,02,66和67的氨基酸序列的载脂蛋白,或其是与所选序列具有至少70%序列同一性的变体 。
摘要:
A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.
摘要翻译:脂质颗粒,其包含载脂蛋白,磷脂酰胆碱和脂质,例如磷脂,脂肪酸或类固醇脂质。 在一个实施方案中,脂质颗粒仅包含一种载脂蛋白。 在一个实施方案中,脂质颗粒由一种载脂蛋白,磷脂,脂质和洗涤剂组成。 在一个实施方案中,脂质是第二磷脂酰胆碱,其中第一磷脂酰胆碱和第二磷脂酰胆碱在一个或两个脂肪酸残基或被酯化成磷脂酰胆碱的甘油骨架的脂肪酸残基衍生物不同。 在一个实施方案中,载脂蛋白选自具有选自SEQ ID NO:01,02,66和67的氨基酸序列的载脂蛋白,或其是与所选序列具有至少70%序列同一性的变体 。
摘要:
Modified phosphodiesterase (PDE) polypeptides with altered physicochemical properties are disclosed, together with the polynucleotides encoding such modified PDE polypeptides, antibodies against such polypeptides and methods of preparation. Such polypeptides are useful for screening assays for identification of agonists or antagonists of phosphodiesterase activity.