-
1.发明授权Shortened tetranectin-apolipoprotein A-I fusion protein, a lipid particle containing it, and uses thereof 有权缩短的tetranectin-载脂蛋白A-I融合蛋白，含有它的脂质颗粒及其用途公开(公告)号：US08791063B2
公开(公告)日：2014-07-29
申请号：US13592183
申请日：2012-08-22
IPC分类号： C07K14/775 , C07K14/705
CPC分类号： C07K14/775 , C07K14/7056 , C07K2319/00 , C12N15/62
摘要： Herein is reported a shortened tetranectin-apolipoprotein A-I fusion protein and a lipid particle comprising the shortened tetranectin-apolipoprotein A-I fusion protein as well as uses thereof.
摘要翻译： 本文报道了缩短的tetranectin-载脂蛋白A-1融合蛋白和包含缩短的tetranectin-载脂蛋白A-1融合蛋白的脂质颗粒及其用途。
-
公开(公告)号：US20070212703A1
公开(公告)日：2007-09-13
申请号：US11528950
申请日：2006-09-27
CPC分类号： G01N33/6845 , C07K14/001 , C07K14/415 , C12N15/1044
摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a taraget molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.
摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计此类产品的文库的方法，筛选此类文库以产生显示针对taraget分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。
-
3.发明申请METHOD FOR PRODUCING A LIPID PARTICLE, THE LIPID PARTICLE ITSELF AND ITS USE 审中-公开生产脂肪颗粒的方法，脂质颗粒及其用途公开(公告)号：US20120190609A1
公开(公告)日：2012-07-26
申请号：US13217536
申请日：2011-08-25
申请人： Martin Bader , Monika Baehner , Adelbert Grossmann , Anton Jochner , Hubert Kettenberger , Silke Mohl
发明人： Martin Bader , Monika Baehner , Adelbert Grossmann , Anton Jochner , Hubert Kettenberger , Silke Mohl
CPC分类号： A61K9/1275 , A61K9/1277 , A61K38/1709 , C07K5/1008 , C07K14/47 , C07K14/775 , C07K2319/00
摘要： A method for producing a lipid particle comprising the following: i) providing a first solution comprising denatured apolipoprotein, ii) adding the first solution to a second solution comprising at least two lipids and a detergent but no apolipoprotein, and iii) removing the detergent from the solution obtained in ii) and thereby producing a lipid particle.
摘要翻译： 一种制备脂质颗粒的方法，包括以下步骤：i）提供包含变性载脂蛋白的第一溶液，ii）将第一溶液加入到包含至少两种脂质和洗涤剂但不含载脂蛋白的第二溶液中，和iii）将去污剂从 在ii）中获得的溶液，从而产生脂质颗粒。
-
公开(公告)号：US20120036964A1
公开(公告)日：2012-02-16
申请号：US13259452
申请日：2010-03-15
申请人： Martin Bader
发明人： Martin Bader
IPC分类号： B67B7/18
CPC分类号： B67B7/18
摘要： Bottle opener for opening a bottle closed with a screw cap, in particular a wine bottle, wherein the bottle opener includes an annular contact element (1) having an inside surface (2) for resting against the screw cap, wthe inside surface (2) delimits a receiving cavity (3) for receiving the screw cap, and the inside surface (2) is delimited by two, preferably circular, edges (4, 4′) of the contact element (1) and the diameter (5) of the receiving cavity (3) delimited by the inside surface (2) decreases at least sectionally, starting from at least one of the edges (4) in the direction toward the other edge (4″), and a counter-clockwise internal thread (6) is formed on the inside surface.
摘要翻译： 开瓶器，用于打开一个用螺帽封闭的瓶子，特别是一个酒瓶，其中开瓶器包括环形接触元件（1），该环形接触元件（1）具有内表面（2），用于靠内螺纹盖（2） 限定用于接收螺旋盖的接收腔（3），并且内表面（2）由接触元件（1）的两个，优选圆形的边缘（4,4'）和直径（5）限定 从内表面（2）限定的接收腔（3）至少从断面方向上朝向另一边缘（4“）的方向从边缘（4）中的至少一个开始，并且逆时针内螺纹 ）形成在内表面上。
-
5.发明申请TETRANECTIN-APOLIPOPROTEIN A-I, LIPID PARTICLES CONTAINING IT AND ITS USE 有权四氯乙烯 - 阿波罗平蛋白A-I，含有它的脂质及其使用公开(公告)号：US20120190610A1
公开(公告)日：2012-07-26
申请号：US13217534
申请日：2011-08-25
申请人： Martin Bader , Monika Baehner , Juergen Fingerle , Ulrich Kohnert , Jean-Luc Mary , Silke Mohl
发明人： Martin Bader , Monika Baehner , Juergen Fingerle , Ulrich Kohnert , Jean-Luc Mary , Silke Mohl
IPC分类号： A61K38/17 , A61P7/00 , C07K14/775 , A61P9/10 , A61P31/00
CPC分类号： C07K14/775 , A61K9/127 , A61K38/1709 , A61K47/186 , A61K47/44 , C07K2319/73
摘要： A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.
摘要翻译： 脂质颗粒，其包含载脂蛋白，磷脂酰胆碱和脂质，例如磷脂，脂肪酸或类固醇脂质。 在一个实施方案中，脂质颗粒仅包含一种载脂蛋白。 在一个实施方案中，脂质颗粒由一种载脂蛋白，磷脂，脂质和洗涤剂组成。 在一个实施方案中，脂质是第二磷脂酰胆碱，其中第一磷脂酰胆碱和第二磷脂酰胆碱在一个或两个脂肪酸残基或被酯化成磷脂酰胆碱的甘油骨架的脂肪酸残基衍生物不同。 在一个实施方案中，载脂蛋白选自具有选自SEQ ID NO：01,02,66和67的氨基酸序列的载脂蛋白，或其是与所选序列具有至少70％序列同一性的变体 。
-
公开(公告)号：US20130231273A1
公开(公告)日：2013-09-05
申请号：US13592183
申请日：2012-08-22
IPC分类号： C07K14/775 , C07K14/705
CPC分类号： C07K14/775 , C07K14/7056 , C07K2319/00 , C12N15/62
摘要： Herein is reported a shortened tetranectin-apolipoprotein A-I fusion protein and a lipid particle comprising the shortened tetranectin-apolipoprotein A-I fusion protein as well as uses thereof.
-
公开(公告)号：US20070191272A1
公开(公告)日：2007-08-16
申请号：US11528927
申请日：2006-09-27
CPC分类号： G01N33/6845 , C07K14/001 , C07K14/415 , C12N15/1044
摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a target molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.
摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计这样的产物的文库的方法，筛选这些文库以产生显示针对目标分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。
-
8.发明授权Tetranectin-apolipoprotein A-I, lipid particles containing it and its use 有权甲状腺素 - 载脂蛋白A-I，含有它的脂质颗粒及其用途公开(公告)号：US09187550B2
公开(公告)日：2015-11-17
申请号：US13217534
申请日：2011-08-25
申请人： Martin Bader , Monika Baehner , Juergen Fingerle , Ulrich Kohnert , Jean-Luc Mary , Silke Mohl
发明人： Martin Bader , Monika Baehner , Juergen Fingerle , Ulrich Kohnert , Jean-Luc Mary , Silke Mohl
CPC分类号： C07K14/775 , A61K9/127 , A61K38/1709 , A61K47/186 , A61K47/44 , C07K2319/73
摘要： A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.
摘要翻译： 脂质颗粒，其包含载脂蛋白，磷脂酰胆碱和脂质，例如磷脂，脂肪酸或类固醇脂质。 在一个实施方案中，脂质颗粒仅包含一种载脂蛋白。 在一个实施方案中，脂质颗粒由一种载脂蛋白，磷脂，脂质和洗涤剂组成。 在一个实施方案中，脂质是第二磷脂酰胆碱，其中第一磷脂酰胆碱和第二磷脂酰胆碱在一个或两个脂肪酸残基或被酯化成磷脂酰胆碱的甘油骨架的脂肪酸残基衍生物不同。 在一个实施方案中，载脂蛋白选自具有选自SEQ ID NO：01,02,66和67的氨基酸序列的载脂蛋白，或其是与所选序列具有至少70％序列同一性的变体 。
-
9.发明申请Intellectual Property Right Valuation Index And A Method And A System For Creating Such An Index 审中-公开知识产权价值指数和创造这样一个指标的方法和制度公开(公告)号：US20120303537A1
公开(公告)日：2012-11-29
申请号：US13449064
申请日：2012-04-17
申请人： Martin Bader , Hendrik Vogel , Marc Tobias , Frauke Rüther , Oliver Gassmann
发明人： Martin Bader , Hendrik Vogel , Marc Tobias , Frauke Rüther , Oliver Gassmann
IPC分类号： G06Q50/00
摘要： A method is disclosed for creating an IP right valuation index for an IP portfolio related to an IP right comprising: capturing a quality indicator signal relating to quality indicator data of the IP right; generating a technology field signal relating to a technology field of the IP right; measuring individual IP technology relevance comprising a ratio of the generated technology field signal and the captured quality indicator signal; capturing a total number signal relating to a total number of IP rights in the technology field; determining an IP portfolio signal relating to the number of IP rights within the captured total number signal having ownership of the IP right; measuring IP portfolio strength comprising a ratio of the determined IP portfolio signal and the captured total number signal; and creating an IP right valuation index comprising a product of the individual IP technology relevance and the IP portfolio strength.
摘要翻译： 公开了一种创建与知识产权相关的知识产权投资组合的知识产权权利评估指标的方法，包括：获取与知识产权权利质量指标数据相关的质量指标信号; 产生与知识产权技术领域相关的技术领域信号; 测量包括产生的技术场信号和所捕获的质量指示符信号的比率的各个IP技术相关性; 捕获与技术领域中知识产权总数相关的总数信号; 确定与拥有知识产权权利的所捕获的总数信号中与知识产权数量有关的IP投资组合信号; 测量IP投资组合强度，其包括所确定的IP投资组合信号与所捕获的总数信号的比率; 并创建知识产权权利评估指数，其中包括个人知识产权技术相关性和知识产权组合实力的产物。
-
公开(公告)号：US5090900A
公开(公告)日：1992-02-25
申请号：US577462
申请日：1990-09-04
申请人： Wagner Rudolf , Martin Bader , Eberhard Moll , Renzo Zanardo , J. G. Van Agtmaal
发明人： Wagner Rudolf , Martin Bader , Eberhard Moll , Renzo Zanardo , J. G. Van Agtmaal
IPC分类号： B05C11/08 , B05C13/00 , B65G49/00 , B65G49/07 , H01L21/00 , H01L21/205 , H01L21/3065 , H01L21/677 , H01L21/687
CPC分类号： H01L21/67167 , H01L21/6719 , H01L21/68707 , Y10S414/135 , Y10S414/137 , Y10S414/139
摘要： A workpiece support for supporting a disc-shaped workpiece in a vacuum chamber, comprises a support member with a support surface for carrying the workpiece. A plurality of bores extend from the support surface and through the support member. The bores communicate with a distribution chamber defined on a side of the support member which is opposite from the support surface. The distribution chamber is substantially co-extensive with the support surface and is connected to a gas feed line for supplying gas to the distribution chamber. The bores each have respective diameters which are substantially shorter than their respective lengths through the support member. In this way, gas supplied through the bores from the distribution chamber is distributed between the support surface and the workpiece as a heat transfer medium which is substantially independent from the gas flow at an inlet of each bore in the distribution chamber.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.021 秒)
