-
Patent Agency Ranking
公开(公告)号：US4054734A
公开(公告)日：1977-10-18
申请号：US664838
申请日：1976-03-08
Applicant: Julio Metzger
Inventor： Julio Metzger
IPC: C07H17/08
CPC classification number: C07H17/08
Abstract: This invention relates to new forms of amphotericin B which comprise amphotericin B, an acid anion, and calcium ion. These new forms of amphotericin retain the activity of amphotericin and have the particular advantage of being soluble in acidic or alkaline solutions.
Abstract translation: 本发明涉及包含两性霉素B，酸性阴离子和钙离子的两性霉素B的新形式。 两性霉素的这些新形式保留了两性霉素的活性，并且具有可溶于酸性或碱性溶液的特殊优点。
-
公开(公告)号：US3965090A
公开(公告)日：1976-06-22
申请号：US550313
申请日：1975-02-18
Applicant: Julio Metzger
Inventor： Julio Metzger
CPC classification number: C07H17/08
Abstract: This invention relates to a new form of amphotericin B which comprises a complex of amphotericin B and succinic acid. This new form of amphotericin B is more active than amphotericin B itself and has the particular advantage of being soluble in acidic or alkaline solutions.
Abstract translation: 本发明涉及两性霉素B的新形式，其包含两性霉素B和琥珀酸的复合物。 这种新型的两性霉素B比两性霉素B本身具有更好的活性，具有可溶于酸性或碱性溶液的特殊优点。
-
公开(公告)号：US4185092A
公开(公告)日：1980-01-22
申请号：US839075
申请日：1977-10-03
Applicant: Julio Metzger
Inventor： Julio Metzger
CPC classification number: C07H17/08
Abstract: Crude, partially purified or contaminated nystatin is purified by suspending the nystatin starting material in water; extracting its activity with sodium lauryl sulfate; adding a chlorinated hydrocarbon solvent; and adding an acid-addition salt of an amine to yield an amorphous precipitate of the nystatin.
Abstract translation: 粗制，部分纯化或污染的制霉菌素通过将制霉菌素起始材料悬浮在水中来纯化; 用十二烷基硫酸钠萃取其活性; 加入氯化烃溶剂; 并加入胺的酸加成盐，得到制霉菌素的无定形沉淀物。
-
公开(公告)号：US4049898A
公开(公告)日：1977-09-20
申请号：US555015
申请日：1975-03-03
Applicant: Julio Metzger
Inventor： Julio Metzger
IPC: C07H17/08
CPC classification number: C07H17/08
Abstract: This invention relates to new forms of amphotericin B which comprise amphotericin B, an acid anion, and calcium ion. These new forms of amphotericin retain the activity of amphotericin and have the particular advantage of being soluble in acidic or alkaline solutions.
Abstract translation: 本发明涉及包含两性霉素B，酸性阴离子和钙离子的两性霉素B的新形式。 两性霉素的这些新形式保留了两性霉素的活性，并且具有可溶于酸性或碱性溶液的特殊优点。
-
公开(公告)号：US4006222A
公开(公告)日：1977-02-01
申请号：US623840
申请日：1975-10-20
Applicant: Julio Metzger
Inventor： Julio Metzger
CPC classification number: C12P19/62
Abstract: Crude, partially purified, or contaminated nystatin is purified by suspending the nystatin starting material in a lower alkanol, treating the suspension with an organic acid, filtering the suspension to remove residual solids, adding a chlorinated hydrocarbon solvent to the alkanol filtrate, neutralizing the mixture, and precipitating the nystatin by the addition of water.
Abstract translation: 粗制，部分纯化或污染的制霉菌素通过将制霉菌素原料悬浮在低级链烷醇中来纯化，用有机酸处理悬浮液，过滤悬浮液以除去残留固体，向烷醇滤液中加入氯化烃溶剂，中和混合物 ，并通过加入水分来沉淀制霉菌素。
-
-
-
-
Search Results
5
records
(took 0.008 seconds)
