公开(公告)号：US20190358953A1

公开(公告)日：2019-11-28

申请号：US16415216

申请日：2019-05-17

Applicant: Junichi IWATA ,  Yoshitaka FUJINUMA ,  Kanshi ABE ,  Takayuki NAKAI ,  Koji KAWAHARA

Inventor： Junichi IWATA ,  Yoshitaka FUJINUMA ,  Kanshi ABE ,  Takayuki NAKAI ,  Koji KAWAHARA

IPC: B41J2/14

Abstract: A liquid discharge head includes a plurality of nozzles arrayed in a nozzle array direction to discharge a liquid; a plurality of pressure chambers arrayed in the nozzle array direction and communicating with the plurality of nozzles, respectively; and a diaphragm forming a displaceable wall of each of the plurality of pressure chambers. The diaphragm includes a concave portion outside an arrangement region of the plurality of pressure chambers in which the plurality of pressure chambers is arrayed in the nozzle array direction.

公开(公告)号：US20170232741A1

公开(公告)日：2017-08-17

申请号：US15431693

申请日：2017-02-13

Applicant: Atsushi Kikuchi ,  Yoshitaka Fujinuma ,  Junichi Iwata

Inventor： Atsushi Kikuchi ,  Yoshitaka Fujinuma ,  Junichi Iwata

IPC: B41J2/14 ,  H01R12/77

CPC classification number: B41J2/1433 ,  B41J2002/14491 ,  H01R12/77 ,  H01R13/516 ,  H01R13/5213

Abstract: A liquid discharge head includes a head body, a wiring member, a connector, and a protector. The head body discharges liquid. The wiring member transmits a signal to the head body. The connector is disposed at the wiring member to connect the wiring member to the head body. The protector covers the head body and the connector. The head body includes a fitting portion. The protector includes a fitting portion to fit the fitting portion of the head body in a fitting direction. The connector is disposed more backward than a leading end of the fitting portion of the protector in the fitting direction.

公开(公告)号：US08637621B2

公开(公告)日：2014-01-28

申请号：US12960236

申请日：2010-12-03

Applicant: Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa

Inventor： Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa

IPC: C08F30/08

CPC classification number: B29D11/00125 ,  C08F220/18 ,  C08F220/54 ,  C08F222/1006 ,  C08F226/02 ,  C08F226/10 ,  C08F230/08 ,  C08F283/12 ,  C08F290/06 ,  C08F290/061 ,  C08F290/065 ,  C08F290/068 ,  G02B1/043 ,  G02C7/04 ,  C08L43/04 ,  C08L83/04 ,  C08L51/085

Abstract: A hydrogel soft contact lens which is superior in extended-wearability, lens movement, wear comfort, and which does not adhere to a cornea when worn is provided. The lens provided can be a silicone hydrogel contact lens which contains units of hydrophilic siloxane monomers and amide-group-containing monomers having an N-vinyl group.

Abstract translation: 提供了延长耐磨性，透镜运动，穿着舒适性以及佩戴时不粘附于角膜的水凝胶软性隐形眼镜。 所提供的透镜可以是含有亲水硅氧烷单体和含有N-乙烯基的含酰胺基的单体的硅氧烷水凝胶隐形眼镜。

公开(公告)号：US20120151612A1

公开(公告)日：2012-06-14

申请号：US13296165

申请日：2011-11-14

Applicant: Yang CHAI ,  Junichi IWATA

Inventor： Yang CHAI ,  Junichi IWATA

IPC: A61K39/395 ,  A61K31/4439 ,  A61K31/4178 ,  C12Q1/68 ,  A01K67/027 ,  A61P43/00 ,  G01N33/566 ,  C40B30/04 ,  A61K31/4184

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  C07K16/2863 ,  C07K2317/76 ,  C12Q1/485 ,  G01N33/74 ,  G01N2333/495 ,  G01N2333/912 ,  G01N2500/10 ,  G01N2800/10

Abstract: The present invention discloses a novel TGF-β signaling mechanism implicated in craniofacial malformation as well as methods and compositions for treating craniofacial malformation utilizing knowledge of the mechanism. Methods of the invention generally comprises administering an effective amount of a TGF-β inhibitor to a subject in need of the treatment. Also disclosed are methods for treating craniofacial malformation by administering Tgf-β, Tgf-βRIII, p38 MAPK inhibitor or neutralizing antibodies to a subject. Also disclosed is a diagnostic method for diagnosing patients at risk of developing craniofacial malformation by determining the level of Tgf-β2 and ectopic p38 MAPK activation. Compounds useful for treating craniofacial malformation may also be discovered by using animal models of the present invention.

Abstract translation: 本发明公开了一种新型TGF- 涉及颅面畸形的信号机制以及利用该机制的知识来治疗颅面畸形的方法和组合物。 本发明的方法通常包括施用有效量的TGF- 抑制剂需要治疗的受试者。 还公开了通过对受试者施用Tgf-＆bgr，Tgf-＆bgr; RIII，p38MAPK抑制剂或中和抗体来治疗颅面畸形的方法。 还公开了通过测定Tgf-＆bgr2和异位p38 MAPK激活的水平来诊断患有颅面畸形风险的患者的诊断方法。 用于治疗颅面畸形的化合物也可以通过使用本发明的动物模型来发现。

公开(公告)号：US20110211158A1

公开(公告)日：2011-09-01

申请号：US12960236

申请日：2010-12-03

Applicant: Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa

Inventor： Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa

IPC: G02C7/04

CPC classification number: B29D11/00125 ,  C08F220/18 ,  C08F220/54 ,  C08F222/1006 ,  C08F226/02 ,  C08F226/10 ,  C08F230/08 ,  C08F283/12 ,  C08F290/06 ,  C08F290/061 ,  C08F290/065 ,  C08F290/068 ,  G02B1/043 ,  G02C7/04 ,  C08L43/04 ,  C08L83/04 ,  C08L51/085

Abstract: A mold for producing a soft contact lens, wherein the mold is capable of forming both front and rear surfaces of the lens from a surface of the mold during polymerization of a monomer composition.

Abstract translation: 一种用于制造软性隐形眼镜的模具，其中所述模具能够在单体组合物聚合期间从所述模具的表面形成所述透镜的前表面和后表面。

公开(公告)号：US20060063852A1

公开(公告)日：2006-03-23

申请号：US11213437

申请日：2005-08-26

Applicant: Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa ,  Arthur Back

Inventor： Junichi Iwata ,  Tsuneo Hoki ,  Seiichirou Ikawa ,  Arthur Back

IPC: G02B1/04

CPC classification number: G02B1/043 ,  C08L83/04 ,  C08L51/085

Abstract: Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and/or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.

公开(公告)号：US20210276326A1

公开(公告)日：2021-09-09

申请号：US17188703

申请日：2021-03-01

Applicant: Junichi Iwata

Inventor： Junichi Iwata

IPC: B41J2/045

Abstract: An image forming apparatus includes: a piezoelectric element with a common electrode on one side and an individual electrode on another side; a nozzle; and circuitry. The circuitry selects one from drive signals and supplies the one drive signal to the piezoelectric element via the individual electrode, to discharge a droplet through the nozzle to form an image. Each drive signal includes waveform pulses including a main pulse that rises in a slope shape during a rising time and finishes rising at an end time. The circuitry generates the drive signals so that the end time of a less influential drive signal other than a most influential drive signal falls within a range of the rising time of the main pulse of the most influential drive signal; selects the one drive signal based on an image to be formed; and supplies the one drive signal to the piezoelectric element.

公开(公告)号：US20200346457A1

公开(公告)日：2020-11-05

申请号：US16934581

申请日：2020-07-21

Applicant: Junichi Iwata ,  Takahiro Yoshida ,  Yukio Otome ,  Tomoaki Murakami

Inventor： Junichi Iwata ,  Takahiro Yoshida ,  Yukio Otome ,  Tomoaki Murakami

IPC: B41J2/14 ,  B41J2/045 ,  B41J2/15

Abstract: A liquid discharge head includes a nozzle to discharge a liquid, an individual chamber communicating with the nozzle, a supply channel communicating with the individual chamber to supply the liquid to the individual chamber, and a discharge channel communicating with the individual chamber to discharge the liquid in the individual chamber. A fluid resistance of the supply channel is greater than a fluid resistance of the discharge channel.

公开(公告)号：US20180194135A1

公开(公告)日：2018-07-12

申请号：US15844831

申请日：2017-12-18

Applicant: Masami IWAMA ,  Yukio OTOME ,  Takahiro YOSHIDA ,  Takakazu KIHIRA ,  Takayuki NAKAI ,  Shiomi ANDOU ,  Isamu SUZUKI ,  Ryuji YOSHIDA ,  Kanshi ABE ,  Junichi IWATA ,  Katsuya ISHll ,  Toshimichi ODAKA

Inventor： Masami IWAMA ,  Yukio OTOME ,  Takahiro YOSHIDA ,  Takakazu KIHIRA ,  Takayuki NAKAI ,  Shiomi ANDOU ,  Isamu SUZUKI ,  Ryuji YOSHIDA ,  Kanshi ABE ,  Junichi IWATA ,  Katsuya ISHll ,  Toshimichi ODAKA

IPC: B41J2/14 ,  B41J2/17 ,  B41J2/175

CPC classification number: B41J2/14233 ,  B41J2/14274 ,  B41J2/1721 ,  B41J2/175 ,  B41J2/17503 ,  B41J2002/14258 ,  B41J2002/14403 ,  B41J2002/14467 ,  B41J2202/12

Abstract: A liquid discharge head includes a plurality of nozzles from which liquid is discharged, a plurality of individual-liquid-chambers communicating with the plurality of nozzles, respectively, a plurality of individual-drainage-channels communicating with the plurality of individual-liquid-chambers, respectively, a drainage-side common-liquid-chamber communicating with each of the plurality of individual-drainage-channels, a filter having filter holes and disposed between the plurality of individual-drainage-channels and the drainage-side common-liquid-chamber, and an intermediate-drainage-channel disposed between the filter and the plurality of individual-drainage-channels. The intermediate-drainage-channel faces the filter and communicates with two or more of the plurality of individual-drainage-channels. A cross-sectional area of the intermediate-drainage-channel is greater than a cross-sectional area of each of the plurality of individual-drainage-channels communicating with the intermediate-drainage-channel in a direction perpendicular to a direction of liquid flow.

公开(公告)号：US08524850B2

公开(公告)日：2013-09-03

申请号：US13411709

申请日：2012-03-05

Applicant: Hiroyuki Ueyama ,  Seiichiro Ikawa ,  Junichi Iwata

Inventor： Hiroyuki Ueyama ,  Seiichiro Ikawa ,  Junichi Iwata

IPC: C08G77/46 ,  C08G77/20

CPC classification number: C08F283/12 ,  C08F8/42 ,  C08F290/06 ,  C08F290/061 ,  C08F290/068 ,  C08G77/38 ,  C08G77/46 ,  G02B1/043 ,  C08L83/12 ,  C08L51/085

Abstract: PROBLEM TO BE SOLVEDTo provide an ophthalmic lens, which can be more safely worn, that is, to provide a material, which is transparent and has high oxygen permeability and a high hydrophilic property, and to provide a novel monomer to be a raw material thereof.SOLUTIONA hydrophilic polysiloxane macromonomer contains polyoxyethylene as a hydrophilic side chains in a polysiloxane main chain, wherein transparency, oxygen permeability, and hydrophilic properties of the material are controlled by regulating the length of the polysiloxane main chain, the length of the hydrophilic polyoxyethylene side chains, and the number of the side chains.

Abstract translation: 要解决的问题为了提供可以更安全地佩戴的眼用镜片，即提供透明且具有高透氧性和高亲水性的材料，并提供作为原料的新型单体 其中。 解决方案亲水性聚硅氧烷大分子单体在聚硅氧烷主链中含有聚氧乙烯作为亲水侧链，其中通过调节聚硅氧烷主链的长度，亲水性聚氧乙烯侧链的长度来控制材料的透明度，透氧性和亲水性 ，和侧链的数量。