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公开(公告)号:US08198323B2
公开(公告)日:2012-06-12
申请号:US12758462
申请日:2010-04-12
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
IPC分类号: A61K31/235 , C12N5/00 , C07C49/10
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译: 本发明涉及能够作为雄激素受体拮抗剂的药物,含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂,特别是用于治疗诸如结肠癌,皮肤癌和前列腺癌的癌症,并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发,多毛症,行为障碍,痤疮和未抑制的精子发生,其中精子发生的抑制是如此期望的。
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公开(公告)号:US20080146660A1
公开(公告)日:2008-06-19
申请号:US12030691
申请日:2008-02-13
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
IPC分类号: A61K31/341 , C07C49/217 , A61K31/12 , A61K31/122 , A61P25/00 , A61P17/14 , A61P35/04 , A61P17/10 , A61P15/00 , C07C205/06 , C12N5/00 , C07D407/06
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
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公开(公告)号:US20050187255A1
公开(公告)日:2005-08-25
申请号:US10966723
申请日:2004-10-15
申请人: Kuo-Hsiung Lee , Li Lin , Charles Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
IPC分类号: C07D317/72 , A61K31/085 , A61K31/12 , A61K31/192 , A61K31/216 , A61K31/22 , A61K31/222 , A61K31/335 , A61K31/357 , A61K31/385 , A61K31/415 , A61P15/08 , A61P17/10 , A61P17/14 , A61P25/02 , A61P31/04 , A61P35/00 , A61P35/02 , A61P43/00 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C59/90 , C07C69/738 , C07C205/45 , C07D231/12 , C07D313/00 , C07D339/06 , A61K31/444 , A61K31/44 , C07D41/02
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译: 本发明涉及能够作为雄激素受体拮抗剂的药物,含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂,特别是用于治疗诸如结肠癌,皮肤癌和前列腺癌的癌症,并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发,多毛症,行为障碍,痤疮和未抑制的精子发生,其中精子发生的抑制是如此期望的。
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公开(公告)号:US07709535B2
公开(公告)日:2010-05-04
申请号:US12030691
申请日:2008-02-13
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译: 本发明涉及能够作为雄激素受体拮抗剂的药物,含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂,特别是用于治疗诸如结肠癌,皮肤癌和前列腺癌的癌症,并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发,多毛症,行为障碍,痤疮和未抑制的精子发生,其中精子发生的抑制是如此期望的。
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公开(公告)号:US07595346B2
公开(公告)日:2009-09-29
申请号:US12030691
申请日:2008-02-13
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
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公开(公告)号:US06575779B1
公开(公告)日:2003-06-10
申请号:US09696243
申请日:2000-10-26
申请人: Kentaro Nagai , Junko Ishida
发明人: Kentaro Nagai , Junko Ishida
IPC分类号: H01R424
CPC分类号: H01R4/2466
摘要: A pressure-contact terminal includes: a contact portion (21); and a pressure-contact portion (32) which has a bottom plate, a pair of side plates formed by bending from the bottom plate in the same direction, and at least a pair of pressure-contact plates (34, 35) formed to stand from the pair of side plates above the bottom plate and to face each other. In the construction, the pressure-contact plates (34, 35) include: electric wire contact portions (34A, 35A) formed by bending which have contact faces (34G, 35G) to be in contact with a core of a covered electric wire; and cover cutting-off portions (34B, 35B ) formed on upper portions of the electric wire contact portions (34A, 35A ) to cut and remove the cover portion of the covered electric wire.
摘要翻译: 压接端子包括:接触部分(21); 和压接部(32),其具有底板,通过从底板沿相同方向弯曲而形成的一对侧板以及形成为支承的至少一对压力接触板(34,35) 从底板上方的一对侧板彼此面对。 在该结构中,压接板(34,35)包括:弯曲形成的电线接触部(34A,35A),其具有与被覆电线的芯接触的接触面(34G,35G) 以及覆盖形成在电线接触部分(34A,35A)的上部上的切断部分(34B,35B),以切割并移除被覆电线的盖部分。
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公开(公告)号:US06561837B1
公开(公告)日:2003-05-13
申请号:US09677770
申请日:2000-10-03
申请人: Junko Ishida
发明人: Junko Ishida
IPC分类号: H01R424
CPC分类号: H01R4/2466 , H01R13/58
摘要: There is provided an insulation displacing terminal having a first engagement part, a housing which has a side wall defining a groove for accommodating the insulation displacing terminal. The side wall has a second engagement part engaging with the first engagement part for locking. The first engagement part is an opening part, and the second engagement part is a projection.
摘要翻译: 提供了具有第一接合部分的绝缘置换端子,壳体具有限定用于容纳绝缘位移端子的凹槽的侧壁。 侧壁具有与第一接合部分接合以锁定的第二接合部分。 第一接合部是开口部,第二接合部是突起。
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公开(公告)号:US06206721B1
公开(公告)日:2001-03-27
申请号:US09272177
申请日:1999-03-18
申请人: Junko Ishida
发明人: Junko Ishida
IPC分类号: H01R424
CPC分类号: H01R4/2466
摘要: A pressure contact terminal includes a bottom plate, a pair of side plates rising from both sides of the bottom plate in same direction and a plurality of pressure contact cutting edges. The pressure contact cutting edges are formed in a manner such that a pair of pressure contact plates are projected from the pair of the side plates so as to face each other. The pressure contact cutting edges formed with a plurality of pressure contact slots into which a covered electric wire is press-fitted. The plurality of pressure contact cutting edges contains at least two wide pressure contact cutting edges having the pressure contact slots with wide width and a narrow pressure contact cutting edge having the pressure contact slot with narrower width than that of the pressure contact slots of the wide pressure contact cutting edges. The narrow pressure contact cutting edge is arranged between the wide pressure contact cutting edges in an axial direction of the covered electric wire.
摘要翻译: 压接端子包括底板,从底板的两侧沿相同方向上升的一对侧板和多个压接切削刃。 压接切削刃的形成方式是使一对压接板从一对侧板突出而彼此面对。 压接触切削刃形成有多个压力接触槽,其中压配有被覆盖的电线。 多个压力接触切削刃包含至少两个宽的压力接触切削刃,其具有宽的宽度的压力接触槽和窄的压力接触切削刃,该压力接触切削刃具有比宽压力的压力接触槽窄的宽度的压力接触槽 接触切削刃。 狭窄的压力接触切削刃配置在被覆电线的轴向的宽压接部切削刃之间。
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公开(公告)号:US20100197784A1
公开(公告)日:2010-08-05
申请号:US12758462
申请日:2010-04-12
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译: 本发明涉及能够作为雄激素受体拮抗剂的药物,含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂,特别是用于治疗诸如结肠癌,皮肤癌和前列腺癌的癌症,并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发,多毛症,行为障碍,痤疮和未抑制的精子发生,其中精子发生的抑制是如此期望的。
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公开(公告)号:US20080161391A1
公开(公告)日:2008-07-03
申请号:US12030678
申请日:2008-02-13
申请人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人: Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
IPC分类号: A61K31/341 , C07C49/217 , A61K31/12 , C07C205/06 , A61P35/04 , A61P17/14 , A61P25/00 , A61P17/10 , A61P15/00 , A61P35/00 , C12N5/00 , A61K31/122 , C07D407/06
CPC分类号: C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译: 本发明涉及能够作为雄激素受体拮抗剂的药物,含有它们的药物制剂及其使用方法。 这些用途包括但不限于用作抗肿瘤剂,特别是用于治疗诸如结肠癌,皮肤癌和前列腺癌的癌症,并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。 雄激素相关疾病的实例包括但不限于秃发,多毛症,行为障碍,痤疮和未抑制的精子发生,其中精子发生的抑制是如此期望的。
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