公开(公告)号：US10765342B2

公开(公告)日：2020-09-08

申请号：US12761760

申请日：2010-04-16

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B5/01 ,  A61B18/22 ,  A61B6/00 ,  A61B5/06 ,  A61N5/06 ,  A61B18/20 ,  A61B17/00 ,  A61B18/00 ,  A61B6/04 ,  A61B8/06 ,  A61B90/00

摘要： An apparatus and method for determining a volume of tissue mass destroyed. The present invention includes a temperature probe and a laser probe having a temperature sensor. The laser probe and temperature probe are inserted to measure a temperature of the tissue mass and a temperature of tissue mass surrounding the tissue mass. By determining the volume of tissue mass destroyed, a graphical representation of the volume of tissue mass destroyed is provided whereby real-time visual monitoring of the destruction of the tissue mass is achieved.

公开(公告)号：US20080188841A1

公开(公告)日：2008-08-07

申请号：US12025162

申请日：2008-02-04

申请人： Anthony J. Tomasello ,  William Graveman ,  Kambiz Dowlatshahi ,  Henry R. Appelbaum

发明人： Anthony J. Tomasello ,  William Graveman ,  Kambiz Dowlatshahi ,  Henry R. Appelbaum

IPC分类号： A61B18/20

CPC分类号： A61N5/0601 ,  A61B18/24 ,  A61B90/11 ,  A61B2017/00101 ,  A61B2018/2005

摘要： An interstitial laser therapy control system is disclosed. The control system includes a thermistor controller apparatus, a microprocessor, a storage device, at least one input device, a display, an electro-mechanical shutter switch, an electro-mechanical emergency shutoff switch, and an electro-mechanical master power switch. The microprocessor is configured to monitor temperatures detected by one or more thermistors connected to the thermistor controller. Based on the temperatures, the microprocessor determines when treatment has been successful and when application of laser energy needs to be halted. The control system also enables an operator to pause and resume treatment using the input device. The electro-mechanical shutter switch sends a signal to a laser source to close a shutter on the laser. The electro-mechanical emergency stop button causes power to be cut off to the laser source. The electro-mechanical master power switch shuts off power to all components in the interstitial laser therapy apparatus.

摘要翻译： 公开了间质激光治疗控制系统。 控制系统包括热敏电阻控制装置，微处理器，存储装置，至少一个输入装置，显示器，机电快门开关，机电紧急切断开关和机电主电源开关。 微处理器被配置为监测由连接到热敏电阻控制器的一个或多个热敏电阻检测到的温度。 基于温度，微处理器确定何时处理成功，何时需要停止激光能量的应用。 控制系统还使得操作者能够使用输入装置暂停和恢复治疗。 机电快门开关向激光源发送信号以关闭激光器上的快门。 机电紧急停止按钮使电源切断到激光源。 机电主电源开关切断间质激光治疗仪中所有部件的电源。

公开(公告)号：US07171253B2

公开(公告)日：2007-01-30

申请号：US11057916

申请日：2005-02-14

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： A61B5/06 ,  A61B5/01 ,  A61B5/064 ,  A61B6/0414 ,  A61B6/502 ,  A61B8/06 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2018/00011 ,  A61B2018/2005 ,  A61B2018/206 ,  A61B2090/063 ,  A61N5/0601

摘要： An apparatus and method for determining a volume of tumor mass destroyed. The present invention includes a temperature probe and a laser probe having a temperature sensor. The laser probe and temperature probe are inserted to measure a temperature of the tumor mass and a temperature of tissue mass surrounding the tumor mass. By determining the volume of tumor mass destroyed, a graphical representation of the volume of tumor mass destroyed is provided whereby real-time visual monitoring of the destruction of the tumor mass is achieved.

摘要翻译： 用于确定破坏的肿瘤块的体积的装置和方法。 本发明包括温度探测器和具有温度传感器的激光探头。 插入激光探头和温度探头以测量肿瘤块的温度和肿瘤块周围的组织质量的温度。 通过确定破坏的肿瘤块的体积，提供破坏的肿瘤块的体积的图示，从而实现对肿瘤块破坏的实时视觉监测。

公开(公告)号：US07041109B2

公开(公告)日：2006-05-09

申请号：US10319765

申请日：2002-12-12

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B19/10

CPC分类号： A61B6/0414 ,  A61B6/502 ,  A61B10/02 ,  A61B18/20 ,  A61B50/20 ,  A61B2018/2005 ,  A61B2090/376 ,  A61N5/0601

摘要： Apparatus and method for performing interstitial laser therapy and adjunctive therapy on a patient are revealed. The apparatus employs a combination of a mammography unit, an interstitial laser treatment device attached to the mammography unit and a treatment platform positioned relative to the mammography unit to enable the interstitial laser therapy to be performed. The use of the treatment platform with the mammography unit enables the interstitial laser therapy to be performed and, if necessary, adjunctive therapy to be performed in the same treatment room without transferring the patient to a new platform.

摘要翻译： 揭示了对患者进行间质激光治疗和辅助治疗的装置和方法。 该装置使用乳房X线照相术单元，连接到乳房X线照相术单元的间质激光治疗装置和相对于乳房X线照相术装置定位的治疗平台的组合，以实现间质激光治疗。 使用具有乳房X线照相术单元的治疗平台能够执行间质激光治疗，并且如果需要，在相同治疗室中进行辅助治疗而不将患者转移到新平台。

公开(公告)号：US20160310199A1

公开(公告)日：2016-10-27

申请号：US14821984

申请日：2015-08-10

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B18/04 ,  A61B34/20

CPC分类号： A61B18/04 ,  A61B34/20 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/046

摘要： A method of removing undesirable cells and killing cells surrounding a cavity caused by the removal of the undesirable cells includes the step of inserting a probe through an incision made in the skin of a patient. The method further includes the steps of removing undesirable cells using the probe and using image-guided technology and inserting a balloon into the cavity formed by the removal of the undesirable cells. Still further, the method includes the steps of conforming the balloon to a shape of the cavity and providing sufficient fluid to fill the cavity based on the volume and reaching a temperature in the fluid to achieve a temperature in the tissue surrounding the cavity that kills cells surrounding the cavity.

摘要翻译： 通过去除不想要的细胞而引起的不想要的细胞和杀死围绕腔的细胞的方法包括将探针插入穿过患者皮肤中的切口的步骤。 该方法还包括以下步骤：使用探针去除不需要的细胞，并使用图像引导技术并将气球插入通过去除不想要的细胞而形成的空腔中。 此外，该方法包括以下步骤：使球囊符合空腔的形状，并提供足够的流体以基于体积填充空腔并达到流体中的温度，以实现空腔周围的组织中的温度，从而杀死细胞 围绕空腔。

公开(公告)号：USD627064S1

公开(公告)日：2010-11-09

申请号：US29298911

申请日：2007-12-14

申请人： Henry R. Appelbaum ,  Kambiz Dowlatshahi ,  William Graveman ,  Anthony J. Tomasello

设计人： Henry R. Appelbaum ,  Kambiz Dowlatshahi ,  William Graveman ,  Anthony J. Tomasello

公开(公告)号：US20060241727A1

公开(公告)日：2006-10-26

申请号：US11381950

申请日：2006-05-05

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61N5/06

CPC分类号： A61B6/0414 ,  A61B6/502 ,  A61B10/02 ,  A61B18/20 ,  A61B50/20 ,  A61B2018/2005 ,  A61B2090/376 ,  A61N5/0601

摘要： Apparatus and method for performing interstitial laser therapy and adjunctive therapy on a patient are revealed. The apparatus employs a combination of a mammography unit, an interstitial laser treatment device attached to the mammography unit and a treatment platform positioned relative to the mammography unit to enable the interstitial laser therapy to be performed. The use of the treatment platform with the mammography unit enables the interstitial laser therapy to be performed and, if necessary, adjunctive therapy to be performed in the same treatment room without transferring the patient to a new platform.

摘要翻译： 揭示了对患者进行间质激光治疗和辅助治疗的装置和方法。 该装置使用乳房X线照相术单元，连接到乳房X线照相术单元的间质激光治疗装置和相对于乳房X线照相术装置定位的治疗平台的组合，以实现间质激光治疗。 使用具有乳房X线照相术单元的治疗平台能够执行间质激光治疗，并且如果需要，在相同治疗室中进行辅助治疗而不将患者转移到新平台。

公开(公告)号：US06865412B2

公开(公告)日：2005-03-08

申请号：US10754827

申请日：2004-01-09

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B5/01 ,  A61B5/00 ,  A61B5/05 ,  A61B5/06 ,  A61B6/00 ,  A61B6/04 ,  A61B8/06 ,  A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B18/24 ,  A61B19/00 ,  A61N5/06

CPC分类号： A61B5/06 ,  A61B5/01 ,  A61B5/064 ,  A61B6/0414 ,  A61B6/502 ,  A61B8/06 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2018/00011 ,  A61B2018/2005 ,  A61B2018/206 ,  A61B2090/063 ,  A61N5/0601

摘要： An apparatus and method for determining a volume of tumor mass destroyed. The present invention includes a temperature probe and a laser probe having a temperature sensor. The laser probe and temperature probe are inserted to measure a temperature of the tumor mass and a temperature of tissue mass surrounding the tumor mass. By determining the volume of tumor mass destroyed, a graphical representation of the volume of tumor mass destroyed is provided whereby real-time visual monitoring of the destruction of the tumor mass is achieved.

公开(公告)号：US5222953A

公开(公告)日：1993-06-29

申请号：US771306

申请日：1991-10-02

申请人： Kambiz Dowlatshahi

发明人： Kambiz Dowlatshahi

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/24 ,  A61N5/06

CPC分类号： A61N5/0601 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/22077 ,  A61B2018/2005

摘要： Improved apparatus for carrying out minimally invasive interstitial laser hyperthermia to induce coagulation necrosis in tissue masses located deeply within the body of a subject. Among examples are malignant tumors in the liver or breast. Low power laser radiation is introduced through an optical fiber extending through a cannula or probe guided into place by medical imaging techniques and inserted directly into the target tissue mass. A thermocouple is secured to the outside of the cannula to sense the temperature of the target tissue irradiated by the laser energy. The thermocouple is located slightly behind the distal end of the cannula and the entire probe assembly is gold plated enabling it to respond primarily to heat transmitted by conduction from the tissue and not by radiation from the laser. In one operating mode described, after the probe is inserted into the tumor, the probe is withdrawn while laser energy is administered at a rate sufficient to maintain the temperature at the thermocouple within a predetermined therapeutic range. In one motorized embodiment, a motor withdraws the cannula at a predetermined speed while the laser is firing, to maintain an effectively high uniform tissue temperature. In another automatic embodiment, the motor speed is controlled in response to the tissue temperature sensed by the thermocouple on the outside of the cannula. This leaves a cylindrical core of necrotic tumor tissue in the wake of the probe as it is drawn through the target tissue.

摘要翻译： 改进的用于进行微创间质激光热疗的装置，以诱导位于受试者体内深处的组织块中的凝固性坏死。 其中例子是肝脏或乳腺中的恶性肿瘤。 低功率激光辐射是通过光纤引入的，该光纤延伸穿过插管或探针通过医学成像技术引导到位，并直接插入目标组织块。 热电偶被固定到套管的外部以感测由激光能量照射的目标组织的温度。 热电偶位于套管远端的后面，整个探针组件镀金，使其能够主要响应从组织传导而不是通过激光辐射传播的热量。 在所描述的一种操作模式中，在将探针插入肿瘤中之后，将探针取出，同时以足以将热电偶的温度保持在预定治疗范围内的速度施用激光能量。 在一个机动化的实施例中，电机在激光烧制时以预定速度退出插管，以保持有效地高均匀的组织温度。 在另一个自动实施例中，响应于套管外部的热电偶感测到的组织温度来控制电动机速度。 当探针通过目标组织被抽出时，这会使得坏死的肿瘤组织的圆柱形芯留下。

公开(公告)号：US5169396A

公开(公告)日：1992-12-08

申请号：US534931

申请日：1990-06-08

申请人： Kambiz Dowlatshahi ,  Charles K. Rhodes

发明人： Kambiz Dowlatshahi ,  Charles K. Rhodes

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/20 ,  A61N5/06

CPC分类号： A61N5/0601 ,  A61B2017/00092 ,  A61B2017/22077 ,  A61B2017/22085 ,  A61B2018/00011 ,  A61B2018/206

摘要： Apparatus and method for locally generating hyperthermia-induced coagulation necrosis in tissue masses located deeply within the body of a subject. High energy laser radiation is introduced into the target tissue mass using an optical fiber inserted into a metallic cannula through which a suitable fluid is coaxially flowed. A combination of the fluid flow and the slow withdrawal of the cannula/fiber combination during therapy protects the optical fiber tip, thereby preserving its energy transmission characteristics. After establishment of a small fluid bolus in front of the fiber tip, fluid flow which is approximately proportionate to the laser energy employed has been found to be most effective in this regard.

摘要翻译： 用于局部产生位于受试者身体内部的组织块中的热疗引起的凝固坏死的装置和方法。 使用插入到金属插管中的光纤将高能激光辐射引入目标组织块中，合适的流体通过该光纤同轴流动。 在治疗期间流体流动和套管/纤维组合的缓慢抽出的组合保护光纤尖端，从而保持其能量传递特性。 在纤维尖端前面建立了小的液体弹丸之后，发现与所使用的激光能量成正比的流体流动在这方面是最有效的。