公开(公告)号：US07553944B2

公开(公告)日：2009-06-30

申请号：US10895064

申请日：2004-07-21

申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

IPC分类号： C07H21/02 ,  C12N15/00 ,  A61K39/00 ,  A61K39/12

CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

公开(公告)号：US07371837B2

公开(公告)日：2008-05-13

申请号：US11129741

申请日：2005-05-16

申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan

发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan

IPC分类号： C07H21/02 ,  C12N15/00 ,  A61K39/00 ,  A61K39/12

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as human coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. Further study on nasopharyngeal aspirates from patients with community-acquired pneumonia has revealed that there are two genotypes, genotype A and genotype B, for this virus. In addition to the genomic sequences of these two genotypes, the invention provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

摘要翻译： 本发明提供了在香港分离的人冠状病毒HKU1（“CoV-HKU1”）的新型人冠状病毒的完整基因组序列。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 对社区获得性肺炎患者的鼻咽抽吸物进一步研究表明，这种病毒有两种基因型，A型和B型基因型。 除了这两种基因型的基因组序列外，本发明提供了CoV-HKU1完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

公开(公告)号：US08092994B2

公开(公告)日：2012-01-10

申请号：US12476019

申请日：2009-06-01

申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

IPC分类号： C12Q1/68

CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronavirdae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于Coronavirdae家族的Nidovirales，为正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

公开(公告)号：US20090305282A1

公开(公告)日：2009-12-10

申请号：US12476019

申请日：2009-06-01

申请人： KWOK YUNG YUEN ,  CHIU YAT PATRICK WOO ,  KAR PUI SUSANNA LAU ,  KWOK HUNG CHAN ,  LIT MAN POON ,  JOSEPH SRIYAL MALIK PEIRIS ,  YI GUAN

发明人： KWOK YUNG YUEN ,  CHIU YAT PATRICK WOO ,  KAR PUI SUSANNA LAU ,  KWOK HUNG CHAN ,  LIT MAN POON ,  JOSEPH SRIYAL MALIK PEIRIS ,  YI GUAN

IPC分类号： C12Q1/68

CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen. China. The virus belongs to the order Nidovirales of the family Coronavirdae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

摘要翻译： 本发明提供了一种新近发生的人冠状病毒的完整基因组序列，该病毒由来自Schenzhen近期病史的患者在香港分离出来，作为冠状病毒HKU1（“CoV-HKU1”）。 中国。 该病毒属于Coronavirdae家族的Nidovirales，为正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。