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13 条记录 (耗时 0.016 秒)

    USE OF VEGFR-2 IN THE TREATMENT OF OPHTHALMIC DISEASES
    1.
    发明申请
    USE OF VEGFR-2 IN THE TREATMENT OF OPHTHALMIC DISEASES 有权
    使用VEGFR-2治疗眼底疾病

    公开(公告)号：US20130109632A1

    公开(公告)日：2013-05-02

    申请号：US13713594

    申请日：2012-12-13

    申请人： KARLSRUHER INSTITUT FUR TECHNOLOGIE

    发明人： Alexandra Matzke ,  Helmut Ponta ,  Véronique Orian-Rousseau ,  Martina Tremmel

    IPC分类号： A61K38/08

    CPC分类号： A61K38/08 ,  A61K38/177

    摘要： The present invention relates to the use of peptide compounds for the prevention and/or treatment of ophthalmic diseases. In particular, the present invention relates to a peptide compound comprising an amino acid sequence displayed by amino acids 7 to 11 of SEQ ID NO: 2 (KEQWFGNRWHEGYR) or of SEQ ID NO: 1 (KEKWFENEWQGKNP), or a functionally active derivative thereof, or a pharmaceutically acceptable salt thereof, for use in the prevention and/or treatmend of an ophthalmic disease in an individual. While SEQ ID NO: 2 is a part of the human CD44v6, SEQ ID NO: 1 is a part of the rat CD44v6.

    摘要翻译： 本发明涉及肽化合物在预防和/或治疗眼科疾病中的应用。 特别地，本发明涉及包含由SEQ ID NO：2（KEQWFGNRWHEGYR）或SEQ ID NO：1（KEKWFENEWQGKNP）的氨基酸7至11显示的氨基酸序列或其功能活性衍生物的肽化合物， 或其药学上可接受的盐，用于预防和/或治疗个体眼科疾病。 虽然SEQ ID NO：2是人CD44v6的一部分，但是SEQ ID NO：1是大鼠CD44v6的一部分。

    PROCESS FOR MAKING AN ELECTRODE ACTIVE MATERIAL, AND ELECTRODE ACTIVE MATERIAL
    2.
    发明申请
    PROCESS FOR MAKING AN ELECTRODE ACTIVE MATERIAL, AND ELECTRODE ACTIVE MATERIAL 有权

    公开(公告)号：US20230002242A1

    公开(公告)日：2023-01-05

    申请号：US17758742

    申请日：2021-02-18

    申请人： BASF SE ,  KARLSRUHER INSTITUT FUR TECHNOLOGIE

    发明人： Matteo BIANCHINI ,  Pascal HARTMANN ,  Torsten BREZESINSKI ,  David KITSCHE ,  Jurgen JANEK

    IPC分类号： C01G53/00

    摘要： Process for making an electrode active material wherein said process comprises the following steps: (a) Providing a hydroxide TM(OH)2 or at least one oxide TMO or oxyhydroxide of TM or combination of at least two of the foregoing wherein TM contains at least 99 mol-% Ni and, optionally, in total up to 1 mol-% of at least one metal selected from Ti, Zr, V, Co, Zn, Ba, or Mg, (b) mixing said hydroxide TM(OH)2 or oxide TMO or oxyhydroxide of TM or combination with a source of lithium and an aqueous solution of a compound of Me wherein Me is selected from Al or Ga or a combination of the foregoing and wherein the molar amount of TM corresponds to the sum of Li and Me, (c) removing the water by evaporation, (d) treating the solid residue obtained from step (c) thermally at a temperature in the range of from 500 to 800° C. in the presence of oxygen.

    SURGICAL CLIP WITH INNER SPRING
    4.
    发明申请
    SURGICAL CLIP WITH INNER SPRING 审中-公开
    带内弹的手术夹

    公开(公告)号：US20150164510A1

    公开(公告)日：2015-06-18

    申请号：US14407944

    申请日：2013-05-28

    申请人： Karlsruher Institut Fur Technologie ,  AESCULAP AG

    发明人： Thomas Pleil ,  Iwiza Tesari ,  Klaus-Dieter Steinhilper ,  Markus Nesper

    IPC分类号： A61B17/122

    CPC分类号： A61B17/1227

    摘要： The present application discloses a surgical clip with two clip branches that each have a clamping portion and an actuating portion, and with a flexion spring arrangement via which the two clip branches are coupled integrally to each other. The flexion spring arrangement has more than a half winding, and an elastic body is arranged in the flexion spring arrangement in such a way that it is deformable by opening the surgical clip.

    摘要翻译： 本申请公开了一种具有两个夹子分支的手术夹子，每个夹子分支具有夹持部分和致动部分，并且具有弯曲弹簧装置，两个夹子分支通过该弯曲弹簧装置彼此一体地连接。 屈曲弹簧装置具有多于一半的绕组，并且弹性体布置在弯曲弹簧装置中，使得其可通过打开手术夹而变形。

    USE OF POROUS HYDROPHOBIC POLYMERS FILLED AND COATED WITH WATER IMMISCIBLE HYDROPHOBIC LIQUIDS FOR PROTEIN- AND CELL-REPELLENT SURFACES
    5.
    发明申请
    USE OF POROUS HYDROPHOBIC POLYMERS FILLED AND COATED WITH WATER IMMISCIBLE HYDROPHOBIC LIQUIDS FOR PROTEIN- AND CELL-REPELLENT SURFACES 审中-公开
    使用多孔疏水性聚合物填充并涂覆水溶性疏水性液体用于蛋白质和细胞表面

    公开(公告)号：US20140087173A1

    公开(公告)日：2014-03-27

    申请号：US14031912

    申请日：2013-09-19

    申请人： Karlsruher Institut fur Technologie

    发明人： Erica Boles ,  Pavel Levkin ,  Ursula Obst ,  Thomas Schwartz ,  Junshen Li

    IPC分类号： B32B3/26 ,  B05D5/00

    CPC分类号： B32B3/26 ,  B05D5/00 ,  C12M39/00 ,  C12N5/0062 ,  C12N2533/30 ,  C12N2535/10 ,  Y10T428/249953

    摘要： The present invention relates to a substrate with a solid support coated with a porous hydrophobic polymer layer or film, wherein said polymer layer or film is coated with a water-immiscible hydrophobic liquid forming a stable film on the polymer surface. The present invention further relates to a method of forming a protein- and cell-repellent surface, comprising the steps of providing a substrate with a solid support coated with a porous hydrophobic polymer layer or film, and applying a water-immiscible hydrophobic liquid to said porous hydrophobic polymer layer or film, a respective method of preventing the formation of biofilms, adhesion of cells and bacteria, and/or migration of cells and bacteria on a surface, as well as the use of a porous hydrophobic polymer layer or film that is coated with a water-immiscible hydrophobic liquid for forming a protein-, cell- and bacteria-repellent surface.

    摘要翻译： 本发明涉及具有涂覆有多孔疏水性聚合物层或膜的固体支持物的基底，其中所述聚合物层或膜涂覆有在聚合物表面上形成稳定膜的与水不混溶的疏水性液体。 本发明还涉及一种形成蛋白质和细胞驱避表面的方法，包括以下步骤：向基底提供涂覆有多孔疏水性聚合物层或膜的固体支持物，并将不溶于水的疏水性液体施加到所述 多孔疏水性聚合物层或膜，防止生物膜形成，细胞和细菌粘附和/或表面上细胞和细菌迁移的各种方法，以及使用多孔疏水聚合物层或膜 涂覆有与水不混溶的疏水液体，用于形成蛋白质，细胞和细菌驱避表面。

    METHOD FOR PRODUCING A MOULDED BODY
    7.
    发明申请
    METHOD FOR PRODUCING A MOULDED BODY 有权

    公开(公告)号：US20210179424A1

    公开(公告)日：2021-06-17

    申请号：US17250087

    申请日：2019-05-24

    申请人： Karlsruher Institut fur Technologie

    发明人： Norbert Schneider ,  Christian Koos ,  Matthias Worgull ,  Philipp-Immanuel Dietrich

    IPC分类号： B81C99/00 ,  B29C59/02 ,  B29C59/00

    摘要： The present invention relates to a method for producing a molded body (10), comprising the following steps: a) providing a molding tool (40) which has at least one receptacle (12) in which at least one material (30) which comprises at least one shape-memory material (31) is introduced, wherein the shape-memory material (31) is present in a first state (111), wherein the material (30) at least partially fills the receptacle (12) of the molding tool (40) in such a manner that said material adjoins at least one surface of the receptacle (12); b) creating a molded body (10) in the receptacle (12) of the molding tool (40) from the material (30), wherein the shape-memory material (31) is present in a second state (112), wherein a form (11) is embossed into the molded body (10) during the second state (112); c) transferring the shape-memory material (31) to a third state (113), wherein the molded body (10) can be deformed during the third state (113) in such a manner that the molded body (10) is demolded from the receptacle (12) of the molding tool (40); and d) at least partially restoring the form (11) of the molded body (10) by transferring the shape-memory material (31) to a fourth state (114), wherein the molded body (10) at least partially resumes the form (11) according to step b) during the fourth state (114).

    METHOD AND APPARATUS FOR DETERMINING A CONCENTRATION OF AEROSOL PARTICLES IN A CARRIER GAS
    8.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING A CONCENTRATION OF AEROSOL PARTICLES IN A CARRIER GAS 审中-公开

    公开(公告)号：US20200003671A1

    公开(公告)日：2020-01-02

    申请号：US16448229

    申请日：2019-06-21

    申请人： Karlsruher Institut fur Technologie

    发明人： Ottmar Mohler ,  Benjamin Murray ,  Michael Adams

    IPC分类号： G01N15/06 ,  H05B3/46 ,  F17C13/02

    摘要： The invention relates to a method (200) and an apparatus (110) for determining a concentration of aerosol particles (112) in a carrier gas (114), in particular for examining atmospheric aerosols (118) or as aerosol particle detector in process gases or in clean air rooms. The method (200) here comprises the steps: a) provision of an aerosol (118) which has aerosol particles (112) in a carrier gas (114) comprising at least one condensable component; b) introduction of at least part of the aerosol (118) into a chamber (120) of a pressure-rated vessel (116), wherein the chamber (120) is delimited by at least one wall (128), wherein the at least one wall (128) adjoining the chamber (120) is set to a temperature which is above a saturation temperature of at least one condensable component; c) subsequent removal of part of the aerosol (118) from the chamber (120), as a result of which a decrease in pressure in the chamber (120) occurs, as a result of which the at least one condensable component condenses at least partly on the aerosol particles (112); and d) determination of a concentration of aerosol particles (112) in the carrier gas (114) during removal of the part of the aerosol (118) from the chamber (120). The invention can be suitable, in particular, for examining atmospheric aerosols, in particular aerosol particles, but can also be used as aerosol particle detector in process gases or in clean air rooms.