公开(公告)号：US20240190942A1

公开(公告)日：2024-06-13

申请号：US18506379

申请日：2023-11-10

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Glenn Dranoff ,  Ryan Sullivan ,  Matthew Vanneman

IPC分类号： C07K14/705 ,  A61K38/17 ,  A61K38/20 ,  A61K45/06 ,  A61P35/00 ,  C07K14/54

CPC分类号： C07K14/7056 ,  A61K38/178 ,  A61K38/2086 ,  A61K45/06 ,  A61P35/00 ,  C07K14/5443 ,  C07K14/70596 ,  C07K2319/30

摘要： Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

公开(公告)号：US11851472B2

公开(公告)日：2023-12-26

申请号：US17096768

申请日：2020-11-12

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Glenn Dranoff ,  Ryan Sullivan ,  Matthew Vanneman

IPC分类号： A61P35/00 ,  A61K45/06 ,  C07K14/705 ,  A61K38/17 ,  A61K38/20 ,  C07K14/54

CPC分类号： C07K14/7056 ,  A61K38/178 ,  A61K38/2086 ,  A61K45/06 ,  A61P35/00 ,  C07K14/5443 ,  C07K14/70596 ,  C07K2319/30

摘要： Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising a dimeric NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. In some embodiments, the molecule further comprises a drug moiety (e.g., an IL15/Ra moiety). The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.

公开(公告)号：US20230310510A1

公开(公告)日：2023-10-05

申请号：US18157633

申请日：2023-01-20

申请人： University of Louisville Research Foundation, Inc. ,  Georgia Tech Research Corporation

发明人： Haval SHIRWAN ,  Andres J. GARCIA ,  Esma S. YOLCU ,  Hong ZHAO ,  Devon HEADEN

IPC分类号： A61K35/39 ,  A61K47/69 ,  A61K47/60 ,  A61P3/08 ,  A61K31/436 ,  A61K35/15 ,  A61K35/28 ,  A61K38/17 ,  C12N15/85

CPC分类号： A61K35/39 ,  A61K47/6903 ,  A61K47/60 ,  A61P3/08 ,  A61K31/436 ,  A61K35/15 ,  A61K35/28 ,  A61K38/178 ,  C12N15/85

摘要： Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for preventing or reducing the risks of rejection of cellular or tissue grafts and/or the treatment of autoimmune disorders such as Type I diabetes. In specific embodiments, the FasL-engineered biomaterials are biotinylated microgels bound to SA-FasL.

公开(公告)号：US20190185532A1

公开(公告)日：2019-06-20

申请号：US16320522

申请日：2017-07-24

申请人： THE UNIVERSITY OF BIRMINGHAM

发明人： Roy Bicknell ,  Kabir Ali Khan

IPC分类号： C07K14/47 ,  C07K16/30 ,  C07K14/725 ,  C07K14/705 ,  A61K45/06 ,  A61K38/17 ,  A61K39/395 ,  A61P35/00 ,  A61K51/08 ,  G01N33/574

CPC分类号： C07K14/4748 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/178 ,  A61K39/39558 ,  A61K45/06 ,  A61K51/08 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/7056 ,  C07K14/70596 ,  C07K14/78 ,  C07K16/2851 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03 ,  G01N33/57492

摘要： The invention provides a portion of multimerin 2 (MMRN2) or a variant thereof, that inhibits the interaction between CLEC14A and MMRN2, in addition to a portion of MMRN2 or a variant thereof, that inhibits the interaction between CD93 and MMRN2. The invention provides compounds comprising said portions and either a cytotoxic moiety or a detectable moiety.

公开(公告)号：US20180311313A1

公开(公告)日：2018-11-01

申请号：US15938839

申请日：2018-03-28

申请人： TOKUSHIMA UNIVERSITY

发明人： Akihito YAMAMOTO ,  Minoru UEDA ,  Kohki MATSUBARA ,  Akio SUZUMURA ,  Koichi FURUKAWA ,  Yoshihiro MATSUSHITA ,  Hirotaka WAKAYAMA ,  Nobunori TAKAHASHI ,  Shin TSUNEKAWA ,  Takako IZUMOTO

IPC分类号： A61K38/19 ,  C12N5/0786 ,  A61K45/06 ,  A61K38/17 ,  A61K31/737

CPC分类号： A61K38/195 ,  A61K31/737 ,  A61K38/178 ,  A61K45/06 ,  C12N5/0645 ,  C12N2501/21 ,  C12N2501/59 ,  C12N2501/90 ,  A61K2300/00

摘要： A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.

公开(公告)号：US20160193294A1

公开(公告)日：2016-07-07

申请号：US14983778

申请日：2015-12-30

申请人： THE UNIVERSITY OF QUEENSLAND

发明人： Jean-Pierre Levesque ,  Ingrid Winkler

IPC分类号： A61K38/17 ,  A61K47/48 ,  A61K31/675 ,  A61K31/70 ,  A61K45/06 ,  A61K38/19

CPC分类号： A61K38/1793 ,  A61K31/00 ,  A61K31/675 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7032 ,  A61K31/7056 ,  A61K38/04 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1732 ,  A61K38/178 ,  A61K38/18 ,  A61K38/193 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6801 ,  A61K2039/505 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/475 ,  C07K14/54 ,  C07K14/70564 ,  C07K16/2854 ,  A61K2300/00

摘要： This invention discloses the use of an E-selectin antagonist and a mobilizer of hematopoietic stem cells or progenitor cells in methods and compositions for treating or preventing immunocompromised conditions resulting from medical treatment. The present invention is particular relevant for prophylaxis and/or treatment of hematopoeitic disorders including neutropenia, agranulocytosis, anemia and thrombocytopenia in individuals receiving or proposed to receive treatments that target rapidly dividing cells or that disrupt the cell cycle or cell division.

摘要翻译： 本发明公开了用于治疗或预防由治疗产生的免疫受损病症的方法和组合物中E-选择素拮抗剂和造血干细胞或祖细胞的移动剂的用途。 本发明特别涉及预防和/或治疗包括中性粒细胞减少症，粒细胞减少症，贫血症和血小板减少症在造血细胞或破坏细胞周期或细胞分裂的接受或建议接受靶向快速分裂细胞的治疗的个体中的造血疾病。

公开(公告)号：US09303072B2

公开(公告)日：2016-04-05

申请号：US14532371

申请日：2014-11-04

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Pin Wang ,  Lili Yang ,  David Baltimore

IPC分类号： A01N63/00 ,  C07K14/005 ,  A61K31/70 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K35/76 ,  C12N15/86 ,  A61K39/21 ,  C12N7/00 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K31/70 ,  A61K35/76 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/178 ,  A61K38/1793 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/204 ,  A61K38/2046 ,  A61K38/2086 ,  A61K39/21 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2810/609 ,  C12N2810/855 ,  Y02A50/386 ,  Y02A50/396 ,  Y02A50/401 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/466 ,  Y02A50/475 ,  Y02A50/48 ,  Y02A50/481 ,  Y02A50/492 ,  A61K2300/00

摘要： Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

摘要翻译： 提供了将编码感兴趣的基因（通常为抗原）的多核苷酸递送至树突状细胞（DC）的方法和组合物。 病毒包膜包含DC-SIGN特异性靶向分子。 方法和相关组合物可用于治疗患有广泛病症的患者，包括感染，例如HIV / AIDS和各种类型的癌症。

公开(公告)号：US09211348B2

公开(公告)日：2015-12-15

申请号：US13814329

申请日：2011-08-09

申请人： Thierry Bettinger ,  Philippe Bussat ,  Samir Cherkaoui ,  Irene Guilbert-Brigger ,  Bernard Lamy

发明人： Thierry Bettinger ,  Philippe Bussat ,  Samir Cherkaoui ,  Irene Guilbert-Brigger ,  Bernard Lamy

IPC分类号： A61K49/22

CPC分类号： A61K49/223 ,  A61K38/178 ,  A61K49/221 ,  A61K49/222 ,  A61K49/227

摘要： Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.

摘要翻译： 与包含氨基酸序列的多肽相关的充气微泡，所述序列对选择素特别是对选择素具有结合亲合力。 充气微泡可用于超声成像。

公开(公告)号：US20150352187A1

公开(公告)日：2015-12-10

申请号：US14654624

申请日：2013-12-24

申请人： NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Akihito YAMAMOTO ,  Minoru UEDA ,  Kohki MATSUBARA ,  Akio SUZUMURA ,  Koichi FURUKAWA ,  Yoshihiro MATSUSHITA ,  Hirotaka WAKAYAMA ,  Nobunori TAKAHASHI ,  Shin TSUNEKAWA ,  Takako IZUMOTO

IPC分类号： A61K38/19 ,  C12N5/0786 ,  A61K31/737 ,  A61K45/06 ,  A61K38/17

CPC分类号： A61K38/195 ,  A61K31/737 ,  A61K38/178 ,  A61K45/06 ,  C12N5/0645 ,  C12N2501/21 ,  C12N2501/59 ,  C12N2501/90 ,  A61K2300/00

摘要： A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.

摘要翻译： 具有能够促进与组织修复相关的反应的组织修复活性的组合物含有选自由具有单核细胞趋化蛋白-1（MCP-1）活性的蛋白质组成的组中的至少一种， 第二组分，其是具有唾液酸结合免疫球蛋白型凝集素-9（Siglec-9）的细胞外结构域活性的蛋白质，以及作为硫酸软骨素和硫酸软骨素蛋白多糖中的至少一种的第三成分。

公开(公告)号：US20150182631A1

公开(公告)日：2015-07-02

申请号：US14416599

申请日：2013-07-19

申请人： Centre National De La Recherche Scientifique-CNRS ,  Universite Paul Sabatier Toulouse III

发明人： Laurent Paquereau ,  Gregori Gross ,  Caroline Ladurantie

IPC分类号： A61K47/48

CPC分类号： A61K47/6415 ,  A61K38/178 ,  A61K45/00 ,  C07K14/37

摘要： The invention relates to the use of fungal sporocarp lectin or of a variant thereof for the delivery of an active agent to a biological target.

摘要翻译： 本发明涉及真菌孢子凝集素或其变体用于将活性剂递送至生物靶的用途。