公开(公告)号：US09051288B2

公开(公告)日：2015-06-09

申请号：US12810608

申请日：2008-12-26

申请人： Katsuyuki Nagai ,  Shinya Kiguchi ,  Hiroya Koyama ,  William Ewan Hume ,  Satoshi Tsujimoto

发明人： Katsuyuki Nagai ,  Shinya Kiguchi ,  Hiroya Koyama ,  William Ewan Hume ,  Satoshi Tsujimoto

IPC分类号： C07D405/04 ,  C07D307/32 ,  C07D307/33

CPC分类号： C07D307/32 ,  C07D307/33 ,  C07D405/04

摘要： Disclosed is a method for mass-producing 4′-ethynyl d4T (4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4′-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.

摘要翻译： 公开了一种通过较简单的方法以低成本大规模生产4'-乙炔基d 4 T（4'-乙炔基-2'，3'-二脱氢-3'-脱氧胸苷）的方法。 具体公开了4'-乙炔基d4T的制造方法，其特征在于，通过使糠醇衍生物或左旋葡萄糖酮与某种化合物反应，将含有三键的基团引入糠醇衍生物或左旋葡萄糖酮中的步骤， 和通过上述步骤获得的由式（III）表示的化合物与胸腺嘧啶反应的步骤。

公开(公告)号：US08736819B2

公开(公告)日：2014-05-27

申请号：US13197078

申请日：2011-08-03

申请人： Katsuyuki Nagai

发明人： Katsuyuki Nagai

IPC分类号： G01C3/08 ,  G01S7/489 ,  G01S17/08 ,  G01S7/486

CPC分类号： G01S7/489 ,  G01C3/08 ,  G01C15/002 ,  G01S7/4868 ,  G01S17/08

摘要： The invention provides a distance measuring instrument, comprising a light emitting unit 13 for emitting a distance measuring light, a photodetecting unit 14 for receiving and detecting a reflected distance measuring light from an object to be measured and a part of the distance measuring light emitted from the light emitting unit as an internal reference light, a sensitivity adjusting unit 23 for electrically adjusting photodetecting sensitivity of the photodetecting unit, and a control arithmetic unit 22 for calculating a measured distance based on a photodetection signal of the reflected distance measuring light from the photodetecting unit and based on a photodetection signal of the internal reference light, wherein the control arithmetic unit can measure a distance by selecting a prism mode measurement and a non-prism mode measurement, and controls so that photodetecting sensitivity of the photodetecting unit is changed by the sensitivity adjusting unit in response to the selected measurement mode.

摘要翻译： 本发明提供了一种距离测量仪器，包括用于发射距离测量光的发光单元13，用于接收和检测来自被测量物体的反射距离测量光的光电检测单元14以及从被测量物体发射的距离测量光的一部分 作为内部基准光的发光单元，用于电光调节光检测单元的光敏灵敏度的灵敏度调节单元23和用于根据来自受光元件的反射距离测量光的光电检测信号计算测量距离的控制运算单元22 并且基于内部参考光的光检测信号，其中控制运算单元可以通过选择棱镜模式测量和非棱镜模式测量来测量距离，并且控制使得光检测单元的光检测灵敏度由 灵敏度调节单元响应于所选择的 测量模式。

公开(公告)号：US20100280235A1

公开(公告)日：2010-11-04

申请号：US12810608

申请日：2008-12-26

申请人： Katsuyuki Nagai ,  Shinya Kiguchi ,  Hiroya Koyama ,  William Ewan Hume ,  Satoshi Tsujimoto

发明人： Katsuyuki Nagai ,  Shinya Kiguchi ,  Hiroya Koyama ,  William Ewan Hume ,  Satoshi Tsujimoto

IPC分类号： C07H19/06 ,  C07D307/02 ,  C07D311/94 ,  C07D309/30

CPC分类号： C07D307/32 ,  C07D307/33 ,  C07D405/04

摘要： Disclosed is a method for mass-producing 4′-ethynyl d4T (4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4′-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.

摘要翻译： 公开了一种通过较简单的方法以低成本大规模生产4'-乙炔基d 4 T（4'-乙炔基-2'，3'-二脱氢-3'-脱氧胸苷）的方法。 具体公开了4'-乙炔基d4T的制造方法，其特征在于，通过使糠醇衍生物或左旋葡萄糖酮与某种化合物反应，将含有三键的基团引入糠醇衍生物或左旋葡萄糖酮中的步骤， 和通过上述步骤获得的由式（III）表示的化合物与胸腺嘧啶反应的步骤。

公开(公告)号：US08699006B2

公开(公告)日：2014-04-15

申请号：US13182670

申请日：2011-07-14

申请人： Katsuyuki Nagai ,  Hajime Honda

发明人： Katsuyuki Nagai ,  Hajime Honda

IPC分类号： G01C3/08

CPC分类号： G01C15/002 ,  G01C1/04 ,  G01C3/04

摘要： The invention provides a measuring instrument, comprising a telescope, a distance measuring unit, an image pickup unit, angle detecting units for detecting a vertical and horizontal angle in the sighting direction, an automatic sighting unit, an arithmetic unit, and a storage unit. The arithmetic unit makes the telescope rotate in horizontal and vertical direction and perform scanning over a predetermined range so that a plurality of objects to be measured are included and makes the image pickup unit acquire digital images during the scanning process. The arithmetic unit detects the objects in the digital images, calculates a vertical and horizontal angle of the objects based on the angle detector and a deviation of each of the objects from sighting axis, associates the calculated angles with each of the objects, and makes the storage unit store the vertical and horizontal angles of the objects as target values for automatic sighting.

摘要翻译： 本发明提供了一种测量仪器，包括望远镜，距离测量单元，图像拾取单元，用于检测瞄准方向上的垂直和水平角度的角度检测单元，自动瞄准单元，运算单元和存储单元。 运算单元使望远镜在水平和垂直方向上旋转，并在预定范围内执行扫描，使得包含多个待测物体，并使图像拾取单元在扫描过程中获取数字图像。 算术单元检测数字图像中的物体，基于角度检测器计算物体的垂直和水平角度，并且将每个物体与瞄准轴的偏差相关联，将计算出的角度与每个物体相关联，并使 存储单元将对象的垂直和水平角存储为自动瞄准的目标值。

公开(公告)号：US20120081692A1

公开(公告)日：2012-04-05

申请号：US13197078

申请日：2011-08-03

申请人： Katsuyuki Nagai

发明人： Katsuyuki Nagai

IPC分类号： G01C3/08

CPC分类号： G01S7/489 ,  G01C3/08 ,  G01C15/002 ,  G01S7/4868 ,  G01S17/08

摘要： The invention provides a distance measuring instrument, comprising a light emitting unit 13 for emitting a distance measuring light, a photodetecting unit 14 for receiving and detecting a reflected distance measuring light from an object to be measured and a part of the distance measuring light emitted from the light emitting unit as an internal reference light, a sensitivity adjusting unit 23 for electrically adjusting photodetecting sensitivity of the photodetecting unit, and a control arithmetic unit 22 for calculating a measured distance based on a photodetection signal of the reflected distance measuring light from the photodetecting unit and based on a photodetection signal of the internal reference light, wherein the control arithmetic unit can measure a distance by selecting a prism mode measurement and a non-prism mode measurement, and controls so that photodetecting sensitivity of the photodetecting unit is changed by the sensitivity adjusting unit in response to the selected measurement mode.

摘要翻译： 本发明提供了一种距离测量仪器，包括用于发射距离测量光的发光单元13，用于接收和检测来自被测量物体的反射距离测量光的光电检测单元14以及从被测量物体发射的距离测量光的一部分 作为内部基准光的发光单元，用于电光调节光检测单元的光敏灵敏度的灵敏度调节单元23和用于根据来自受光元件的反射距离测量光的光电检测信号计算测量距离的控制运算单元22 并且基于内部参考光的光检测信号，其中控制运算单元可以通过选择棱镜模式测量和非棱镜模式测量来测量距离，并且控制使得光检测单元的光检测灵敏度由 灵敏度调节单元响应于所选择的 测量模式。

公开(公告)号：US20120081690A1

公开(公告)日：2012-04-05

申请号：US13182670

申请日：2011-07-14

申请人： Katsuyuki Nagai ,  Hajime Honda

发明人： Katsuyuki Nagai ,  Hajime Honda

IPC分类号： G01C3/08

CPC分类号： G01C15/002 ,  G01C1/04 ,  G01C3/04

摘要： The invention provides a measuring instrument, comprising a telescope, a distance measuring unit, an image pickup unit, angle detecting units for detecting a vertical and horizontal angle in the sighting direction, an automatic sighting unit, an arithmetic unit, and a storage unit. The arithmetic unit makes the telescope rotate in horizontal and vertical direction and perform scanning over a predetermined range so that a plurality of objects to be measured are included and makes the image pickup unit acquire digital images during the scanning process. The arithmetic unit detects the objects in the digital images, calculates a vertical and horizontal angle of the objects based on the angle detector and a deviation of each of the objects from sighting axis, associates the calculated angles with each of the objects, and makes the storage unit store the vertical and horizontal angles of the objects as target values for automatic sighting.

摘要翻译： 本发明提供了一种测量仪器，包括望远镜，距离测量单元，图像拾取单元，用于检测瞄准方向上的垂直和水平角度的角度检测单元，自动瞄准单元，运算单元和存储单元。 运算单元使望远镜在水平和垂直方向上旋转，并在预定范围内执行扫描，使得包含多个待测物体，并使图像拾取单元在扫描过程中获取数字图像。 算术单元检测数字图像中的物体，基于角度检测器计算物体的垂直和水平角度，并且将每个物体与瞄准轴的偏差相关联，将计算出的角度与每个物体相关联，并使 存储单元将对象的垂直和水平角存储为自动瞄准的目标值。

公开(公告)号：US20100256379A1

公开(公告)日：2010-10-07

申请号：US12739795

申请日：2008-10-22

申请人： Masanori Baba ,  Yuichi Hashimoto ,  Hiroshi Aoyama ,  Kumiko Sako ,  Shinichi Sato ,  Katsuyuki Nagai

发明人： Masanori Baba ,  Yuichi Hashimoto ,  Hiroshi Aoyama ,  Kumiko Sako ,  Shinichi Sato ,  Katsuyuki Nagai

IPC分类号： C07D471/04

CPC分类号： C07D209/86 ,  C07D307/91 ,  C07D471/04

摘要： The present invention relates to an anti-viral agent comprising a compound represented by the following formula (I): (wherein X represents CH, a nitrogen atom, an oxygen atom, or a sulfur atom; Y and Z are the same or different and each represents a nitrogen atom or C—R8, and at least one of them represents a nitrogen atom; R1 to R8 are the same or different and each represents a hydrogen atom, a linear C1-10-hydrocarbon group, a hydroxy group, or a substituted or unsubstituted benzyl group; and, when X represents an oxygen atom or a sulfur atom, R5 is absent), or the following formula (II): (wherein X′ represents CH or a nitrogen atom; Y′ and Z′ are the same or different and each represents a nitrogen atom or N—R9, or C—R8 and at least one of them represents a nitrogen atom or N—R9; R1 to R4 and R6 to R8 are as defined above; R9 represents a hydrogen atom, a linear C1-10-hydrocarbon group, a hydroxy group, or a substituted or unsubstituted benzyl group; and, the C ring has the maximum number of double bonds at the dotted line portion) or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及包含由下式（I）表示的化合物的抗病毒剂：（其中X表示CH，氮原子，氧原子或硫原子; Y和Z相同或不同， 各自表示氮原子或C-R8，并且其中至少一个表示氮原子; R 1〜R 8相同或不同，表示氢原子，直链C 1-10烃基，羟基或 取代或未取代的苄基;当X表示氧原子或硫原子时，R 5不存在）或下式（II）表示：（其中X'表示CH或氮原子，Y'和Z'为 相同或不同，各自表示氮原子或N-R9或C-R8，并且其中至少一个表示氮原子或N-R 9; R 1至R 4和R 6至R 8如上所定义; R 9表示氢 原子，直链C 1-10烃基，羟基或取代或未取代的苄基;和C环h 作为虚线部分的双键的最大数目）或其药学上可接受的盐。

公开(公告)号：US08908169B2

公开(公告)日：2014-12-09

申请号：US13182675

申请日：2011-07-14

申请人： Katsuyuki Nagai

发明人： Katsuyuki Nagai

IPC分类号： G01C3/04 ,  G01S7/48 ,  G01S17/89 ,  G01C1/04 ,  G01S7/497 ,  G01C15/00 ,  G01S17/42 ,  G03B37/00 ,  G01C3/08 ,  G01S7/481

CPC分类号： G01S7/4972 ,  G01C1/04 ,  G01C3/04 ,  G01C3/08 ,  G01C15/002 ,  G01S7/4808 ,  G01S7/4817 ,  G01S17/42 ,  G01S17/89 ,  G03B37/00

摘要： The invention provides a measuring method for performing monitoring measurement on a plurality of measuring points by using a measuring instrument, which comprises a telescope unit, a distance measuring unit, an image sensor, angle detecting units for detecting a directional angle in sighting direction, and an arithmetic unit. The monitoring measurement comprises a coarse monitoring measurement for acquiring a digital image in measuring direction and for performing angle measurement on the measuring point, and a precise monitoring measurement for performing sighting of the measuring point by the telescope unit and for performing distance measurement and angle measurement, and wherein the coarse monitoring measurement is executed on each of the measuring points, a deviation of a result of the coarse measurement by the coarse monitoring measurement from the initial value is determined, and the precise monitoring measurement is executed on the measuring point where the deviation exceeds a first threshold value.

摘要翻译： 本发明提供了一种通过使用测量仪器对多个测量点进行监视测量的测量方法，所述测量仪器包括望远镜单元，距离测量单元，图像传感器，用于检测瞄准方向上的方向角度的角度检测单元，以及 一个算术单元。 监视测量包括用于在测量方向上获取数字图像并在测量点上执行角度测量的粗略监视测量，以及用于通过望远镜单元执行测量点的瞄准和用于执行距离测量和角度测量的精确监视测量 ，并且其中对每个测量点执行粗略监测测量，确定通过粗略监测测量的粗略测量结果与初始值的偏差，并且在测量点上执行精确的监测测量， 偏差超过第一阈值。

公开(公告)号：US20120081691A1

公开(公告)日：2012-04-05

申请号：US13182675

申请日：2011-07-14

申请人： Katsuyuki Nagai

发明人： Katsuyuki Nagai

IPC分类号： G01C3/08

CPC分类号： G01S7/4972 ,  G01C1/04 ,  G01C3/04 ,  G01C3/08 ,  G01C15/002 ,  G01S7/4808 ,  G01S7/4817 ,  G01S17/42 ,  G01S17/89 ,  G03B37/00

摘要： The invention provides the measuring method for performing monitoring measurement on a plurality of measuring points by using a measuring instrument 1, which comprises a telescope unit for performing sighting of a measuring point where an initial value is already known, a distance measuring unit 29 for measuring a distance to the measuring point by projecting a distance measuring light through the telescope unit, an image sensor 23 for taking an image in direction of measurement and for acquiring a digital image, angle detecting units 31, 32 each for detecting a directional angle in sighting direction of the telescope unit, and an arithmetic unit 27 for making the telescope unit perform automatic sighting to the measuring point and for calculating directional angles of the measuring point based on a deviation of the measuring point on the digital image from a sighting axis and based on a result of detection from the angle detecting unit, wherein the monitoring measurement comprises a coarse monitoring measurement for acquiring a digital image in measuring direction and for performing angle measurement on the measuring point from the digital image, and a precise monitoring measurement for performing sighting of the measuring point by the telescope unit and for performing distance measurement by the distance measuring unit and angle measurement by the angle detecting unit, and wherein the coarse monitoring measurement is executed on each of the measuring points, a deviation of a result of the coarse measurement by the coarse monitoring measurement from the initial value is determined, and the precise monitoring measurement is executed on the measuring point where the deviation exceeds a first threshold value.

摘要翻译： 本发明提供了一种使用测量仪器1对多个测量点进行监视测量的测量方法，该测量仪器包括用于执行初始值已知的测量点的望远镜单元，用于测量测量点的距离测量单元29 通过将距离测量光投射到望远镜单元上而到测量点的距离，用于在测量方向上拍摄图像并用于获取数字图像的图像传感器23，每个用于检测瞄准中的方向角度的角度检测单元31,32 望远镜单元的方向和用于使望远镜单元对测量点进行自动瞄准并且基于数字图像上的测量点与瞄准轴的偏差来计算测量点的方位角的运算单元27，并且基于 根据来自角度检测单元的检测结果，其中监视测量包括ac 用于在测量方向上获取数字图像并从数字图像对测量点执行角度测量的精细监测测量，以及用于通过望远镜单元执行测量点的精确监测测量，以及通过距离测量进行距离测量 通过角度检测单元进行单位和角度测量，并且其中对每个测量点执行粗略监测测量，确定粗略监测测量结果与初始值的偏差，并且精确监测 在偏差超过第一阈值的测量点执行测量。

公开(公告)号：US6163912A

公开(公告)日：2000-12-26

申请号：US139339

申请日：1998-08-24

申请人： Sadahiro Matsuura ,  Shigeru Satou ,  Toru Tazawa ,  Katsuyuki Nagai ,  Yoshiaki Igarashi

发明人： Sadahiro Matsuura ,  Shigeru Satou ,  Toru Tazawa ,  Katsuyuki Nagai ,  Yoshiaki Igarashi

IPC分类号： D06F37/20 ,  D06F37/30 ,  D06F39/00 ,  H02P21/14 ,  D06F33/04

CPC分类号： D06F37/304 ,  D06F37/203 ,  D06F39/003 ,  D06F2202/12 ,  H02P21/18 ,  Y02B40/52

摘要： A torque current component and an exciting current component of primary AC currents which are supplied to a stator of a three-phase induction motor are commanded independently of each other in accordance with a command rotational angular velocity and a rotational angular velocity of the three-phase induction motor rotating an agitator, and the rotational angular velocity of the three-phase induction motor is controlled by changing the magnitude and frequency of each of the primary AC currents. Furthermore, a test operation is carried out by giving the command angular velocity so as to make constant the angular velocity of the motor, and the laundry amount is estimated corresponding to an output torque of the motor in the test operation.

摘要翻译： 提供给三相感应电动机的定子的一次交流电流的转矩电流分量和励磁电流分量根据三相感应电动机的指令旋转角速度和旋转角速度彼此独立地指令 旋转搅拌器的感应电动机，并且通过改变每个主要AC电流的幅度和频率来控制三相感应电动机的旋转角速度。 此外，通过给出指令角速度以使马达的角速度恒定来进行测试操作，并且根据测试操作中的马达的输出转矩来估计衣物量。