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    Fused 7-membered cyclic compound and antipsychotic preparation containing the same
    2.
    发明授权
    Fused 7-membered cyclic compound and antipsychotic preparation containing the same 失效
    熔融的7元环化合物和含有其的抗精神病药制剂

    公开(公告)号：US5312625A

    公开(公告)日：1994-05-17

    申请号：US60701

    申请日：1993-05-11

    申请人： Toshio Tatsuoka ,  Kayoko Nomura

    发明人： Toshio Tatsuoka ,  Kayoko Nomura

    IPC分类号： C07D243/12 ,  A61K31/55 ,  A61K31/554 ,  A61P25/00 ,  A61P43/00 ,  C07D223/16 ,  C07D243/14 ,  C07D281/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  A61F13/00

    CPC分类号： C07D223/16 ,  C07D243/14 ,  C07D281/10 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： A therapeutically effective antipsychotic preparation comprising a fused cyclic compound for the treatment of diseases involving the serotonergic pathway having the formula (I) or salts thereof: ##STR1## wherein both of A and B are carbonyl groups, or one represents a methylene group and the other a carbonyl group, Z represents a sulfur atom, or a nitrogen atom which may be substituted, or a methylene group, R represents an aromatic or heterocylcic group, which may be substituted, X represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.5 lower alkyl group, a C.sub.1 -C.sub.5 lower alkoxy group, a C.sub.7 -C.sub.9 arylalkoxy group, a C.sub.1 -C.sub.5 lower acyloxy group, a C.sub.7 -C.sub.10 arylcarbonyloxy group, a hydroxy group, a nitro group or an ester group, and n is an integer of 2 to 10.

    摘要翻译： 一种治疗有效的抗精神病药物，其包含用于治疗涉及具有式（I）的5-羟色胺能途径的疾病或其盐的稠合环化合物：其中A和B都是羰基，或一个代表亚甲基 基团，另一个是羰基，Z表示硫原子，或可以被取代的氮原子，或亚甲基，R表示可被取代的芳族或杂环基，X表示氢原子，卤素原子 C1-C5低级烷基，C1-C5低级烷氧基，C7-C9芳基烷氧基，C1-C5低级酰氧基，C7-C10芳基羰基氧基，羟基，硝基或酯基 ，n为2〜10的整数。

    Agents for treating disorders from cerebral neuro-degeneration
    5.
    发明授权
    Agents for treating disorders from cerebral neuro-degeneration 失效
    用于治疗来自脑神经衰弱的疾病的药剂

    公开(公告)号：US5155129A

    公开(公告)日：1992-10-13

    申请号：US662105

    申请日：1991-02-28

    申请人： Toshio Tatsuoka ,  Kayoko Nomura ,  Yuzo Nakagawa ,  Shizuo Nakamura

    发明人： Toshio Tatsuoka ,  Kayoko Nomura ,  Yuzo Nakagawa ,  Shizuo Nakamura

    IPC分类号： A61K31/35 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P25/28 ,  C07D311/94 ,  C07D315/00

    CPC分类号： A61K31/35 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  C07D311/94

    摘要： A therapeutic agent for alleviating disorders caused by nerve cell degeneration in the brain which contains a cyclopropachromen derivative represented by the following general formula (I): ##STR1## wherein n is an integer of from 2 to 5;the carbon atom in the --(CH.sub.2).sub.n -- moiety may be optionally substituted with a methyl group or a hydroxyl group;R.sup.1 and R.sup.2 independently represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; or alternatively R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group;A.sup.1 and A.sup.2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an optionally substituted alkoxy group, an acyloxy group, a carbamyloxy group or an optionally substituted carboxyl group;and B.sup.1 and B.sup.2 independently represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an optionally substituted carboxyl group;or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutical carrier or adjuvant.

    Benzoxazepine derivative
    6.
    发明授权
    Benzoxazepine derivative 失效
    苯并噻唑衍生物

    公开(公告)号：US5071845A

    公开(公告)日：1991-12-10

    申请号：US454273

    申请日：1989-12-21

    申请人： Toshio Tatsuoka ,  Kayoko Nomura ,  Makoto Shibata

    发明人： Toshio Tatsuoka ,  Kayoko Nomura ,  Makoto Shibata

    IPC分类号： C07D267/14 ,  C07D413/12

    CPC分类号： C07D413/12 ,  C07D267/14

    摘要： A benzoxazepine derivative suitable for use as a psychotropic composition having the formula: ##STR1## wherein A and B are both carbonyl groups, or one thereof represents a methylene group and the other a carbonyl group, R represents an aromatic group or a heterocyclic group, which may be substituted, X represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.5 lower alkyl group, a C.sub.1 -c.sub.5 lower alkoxy group, a C.sub.7 -C.sub.9 arylalkoxy group, a hydroxyl group, a nitro group, or an ester group, and n is an integer of 2 to 10 and salts thereof.