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公开(公告)号：US06267981B1
公开(公告)日：2001-07-31
申请号：US09571728
申请日：2000-05-15
IPC分类号： A61F200
CPC分类号： A61K38/27 , A61K9/1647 , A61K9/5031 , A61K38/28
摘要： This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.
摘要翻译： 本发明提供包含可生物降解的聚合物金属盐和活性多肽的持续释放制剂，其具有增强的生物活性多肽捕获，抑制初始爆发以及生物活性多肽的恒定长期释放。
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公开(公告)号：US5665394A
公开(公告)日：1997-09-09
申请号：US723152
申请日：1996-09-30
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
摘要翻译： 本发明涉及用于缓释制剂的基质，其包含在直链聚酯的末端羧基上形成的酯，其基本上由α-羟基单羧酸组成。 基质对光，热，水分，着色等均稳定，毒性低。 通过使用本发明的酯制备的缓释制剂在延长的时间内提供稳定的药物释放，确保持续的稳定的效果。 此外，缓释制剂在施用后不显示过量的药物释放。
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公开(公告)号：US5594091A
公开(公告)日：1997-01-14
申请号：US391699
申请日：1995-02-21
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
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公开(公告)号：US5534269A
公开(公告)日：1996-07-09
申请号：US270838
申请日：1994-07-05
CPC分类号： A61K9/1694 , A61K9/1647 , Y10S514/964
摘要： A method of producing a sustained-release preparation which includes permitting a water-soluble polypeptide to permeate into a biodegradable matrix in the aqueous solution. The production method of the present invention makes possible the permeation of a water-soluble polypeptide into a biodegradable matrix without bringing the water-soluble polypeptide into contact with an organic solvent. Hence the water-soluble polypeptide is prepared without affecting the water-soluble polypeptide bioactivity and is thus effective for use as a pharmaceutical.
摘要翻译： 一种制备缓释制剂的方法，其包括使水溶性多肽渗透到水溶液中的可生物降解的基质中。 本发明的制备方法使水溶性多肽渗入可生物降解的基质成为可能，而不会使水溶性多肽与有机溶剂接触。 因此，制备水溶性多肽而不影响水溶性多肽生物活性，因此有效地用作药物。
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