公开(公告)号：US5351651A

公开(公告)日：1994-10-04

申请号：US83234

申请日：1993-06-29

申请人： Kazumichi Ushio ,  Takaichi Kinoshita

发明人： Kazumichi Ushio ,  Takaichi Kinoshita

IPC分类号： A01K63/04 ,  C02F1/00

CPC分类号： A01K63/04 ,  C02F1/00

摘要： An improved composition for preparing artificial sea-water comprises an electrolyte mixture which, upon being dissolved in a proper amount of water, forms an aqueous solution which simulates natural sea-water in composition except that it contains one or more boron compounds within a concentration range from 0.002 to 0.05 w/v % calculated as boron. The pH stability of an artificial sea-water is improved by adding one or more boron compounds thereto.

摘要翻译： 用于制备人造海水的改进组合物包括电解质混合物，其在溶解在适量的水中后，形成模拟组合物中天然海水的水溶液，除了其含有一种或多种浓度范围内的硼化合物 以0.002至0.05w / v％计算为硼。 通过向其中加入一种或多种硼化合物来改善人造海水的pH稳定性。

公开(公告)号：US4910225A

公开(公告)日：1990-03-20

申请号：US301033

申请日：1989-01-24

申请人： Takahiro Ogawa ,  Yoshikazu Kuribayashi ,  Kazumichi Ushio ,  Akira Ohtori

发明人： Takahiro Ogawa ,  Yoshikazu Kuribayashi ,  Kazumichi Ushio ,  Akira Ohtori

IPC分类号： A61K9/00 ,  A61K31/195 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  C07C229/40

CPC分类号： A61K31/195 ,  A61K9/0048

摘要： This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient.An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type.The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.

公开(公告)号：US5663170A

公开(公告)日：1997-09-02

申请号：US912580

申请日：1992-07-13

申请人： Kazumichi Ushio ,  Yoshifumi Ikejiri

发明人： Kazumichi Ushio ,  Yoshifumi Ikejiri

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K31/535 ,  A61K31/538 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40 ,  A61K47/48 ,  A61P27/02

CPC分类号： B82Y5/00 ,  A61K31/535 ,  A61K31/538 ,  A61K47/40 ,  A61K47/48969 ,  A61K9/0048 ,  Y10S514/912

摘要： A composition for eye drops comprising as a main effective component 3,4-dihydro-2,8-diisopropyl-3-thioxo-2H-1,4-benzoxadine-4-acetic acid or a pharmaceutically acceptable salt thereof and cyclodextrin is disclosed.

摘要翻译： 公开了一种含有作为主要有效成分的3,4-二氢-2,8-二异丙基-3-硫代-2H-1,4-苯并恶嗪-4-乙酸或其药学上可接受的盐和环糊精的滴眼剂组合物。

公开(公告)号：US5366985A

公开(公告)日：1994-11-22

申请号：US946443

申请日：1992-11-16

申请人： Hisayuki Nakayama ,  Kazumichi Ushio ,  Katsuhiro Inada

发明人： Hisayuki Nakayama ,  Kazumichi Ushio ,  Katsuhiro Inada

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K31/425 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K31/425 ,  Y10S514/912

摘要： A stable aqueous suspension, which is particularly suitable for eyedrops for the treatment of keratopathy and other diseases, containing 5-(3-ethoxy-4-n-pentyloxyphenyl)thiazolidine-2,4-dione can be prepared by adding an acid to an aqueous solution containing one or more members selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropylmethylcellulose, methylcellulose and hydroxyethylcellulose and 5-(3-ethoxy-4-n-pentyloxyphenyl)thiazolidine-2,4-dione and having a pH value of not lower than 8 to adjust said aqueous solution to a pH value of not higher than 7.

摘要翻译： PCT No.PCT / JP91 / 00932 Sec。 371日期：1992年11月16日 102（e）日期1992年11月16日PCT提交1991年7月11日PCT公布。 出版物WO92 / 17174 日本10月15日，1992年。一种稳定的水性悬浮液，其特别适用于含有5-（3-乙氧基-4-正戊基氧基苯基）噻唑烷-2,4-二酮的眼药水治疗角膜病和其他疾病，可以是 通过向含有一种或多种选自聚乙烯醇，聚乙烯吡咯烷酮，羟丙基甲基纤维素，甲基纤维素和羟乙基纤维素的组分的水溶液中加入酸和5-（3-乙氧基-4-正戊基氧基苯基）噻唑烷-2,4- 并且pH值不低于8以将所述水溶液调节至不高于7的pH值。

公开(公告)号：US5518990A

公开(公告)日：1996-05-21

申请号：US406810

申请日：1995-03-20

申请人： Kazumichi Ushio ,  Yoshiki Makimoto

发明人： Kazumichi Ushio ,  Yoshiki Makimoto

IPC分类号： A01N59/16

CPC分类号： A01N59/16

摘要： A method for inhibiting or preventing emergence and growth of algae, comprising use of a germanium compound and a herbicide, and an antialgal composition comprising a germanium compound and a herbicide. The method of the present invention inhibits and prevents emergence and growth of algae, and can be used safely with little influence on aquatic animals. The method is advantageously used for a fish tank in which fish for appreciation is kept, so as to keep good appearance of the tank and to reduce burden of cleaning the tank by preventing emergence and growth of attached algae. Particularly, the composition for artificial seawater of the present invention shows no toxicity to marine animals to be raised in the artificial seawater prepared using the composition of the invention, and can inhibit and prevent emergence of algae. Therefore, the composition of the invention can be beneficially used for raising, culture, study, and the like of marine animals. Moreover, the composition of the present invention which is coated on a fish net, a hull, or the like can result in inhibition and prevention of emergence and growth of algae in the environment where influence on fish, etc. is very little.

摘要翻译： 一种抑制或预防藻类出现和生长的方法，包括使用锗化合物和除草剂，以及包含锗化合物和除草剂的抗佐剂组合物。 本发明的方法抑制和防止藻类的出现和生长，并且可以安全地使用，对水生动物几乎没有影响。 该方法有利地用于其中保存有欣赏鱼的鱼缸，以便保持罐的良好外观，并通过防止附着的藻类的出现和生长来减轻清洗罐的负担。 特别地，本发明的人造海水用组合物对使用本发明的组合物制造的人造海水中的海洋动物没有毒性，并且可以抑制和防止藻类的出现。 因此，本发明的组合物可以有益地用于海洋动物的养殖，培养，研究等。 此外，涂覆在鱼网，船体等上的本发明的组合物可以抑制和防止对鱼类等的影响很小的环境中的藻类的出现和生长。

公开(公告)号：US5185372A

公开(公告)日：1993-02-09

申请号：US751885

申请日：1991-08-29

申请人： Kazumichi Ushio ,  Kenichi Yoshida

发明人： Kazumichi Ushio ,  Kenichi Yoshida

IPC分类号： A61J1/05 ,  A61J1/10 ,  A61K9/00 ,  A61K9/08 ,  A61K31/07 ,  A61K31/19 ,  A61K31/195 ,  A61K31/198 ,  A61K31/215 ,  A61K31/23 ,  A61K47/02 ,  A61K47/12 ,  A61K47/16 ,  A61K47/34 ,  A61P27/02

CPC分类号： A61K31/23 ,  A61K9/0048 ,  Y10S514/912

摘要： Presented is a stable aqueous preparation for ophthalmic topical administration containing vitamin A or a vitamin A derivative having vitamin A activities to be used for the treatment of dry eye syndrome characterized in that it contains a buffering component selected from the group consisting of phosphoric acid, boric acid, citric acid, glutamic acid, .epsilon.-aminocaproic acid and the alkali metal salts thereof, a non-ionic surfactant and a chelating agent, that its acidity is adjusted in the range of pH 5 to pH 8, and that it is filled in a tight container made of polypropylene or polyethylene terephthalate.

公开(公告)号：US5125982A

公开(公告)日：1992-06-30

申请号：US744376

申请日：1991-08-13

申请人： Ogata Kazumi ,  Kazumichi Ushio ,  Hisayuki Nakayama

发明人： Ogata Kazumi ,  Kazumichi Ushio ,  Hisayuki Nakayama

IPC分类号： G02C13/00 ,  A61L12/12 ,  C11D3/00 ,  C11D3/39

CPC分类号： A61L12/124 ,  C11D3/0078 ,  C11D3/3942

摘要： The object of the invention is to provide a method of cleaning a hard contact lens which is easy to use, excellent in the cleaning effect and then does not affect the lens material disadvantageously. The method of cleaning a hard contact lens is characterized in that the hard contact lens adhered with soil is immersed in a mixture of an aqueous solution of a permanganate salt and an aqueous solution of a mild reducing substance.