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1.发明申请Transdermal Preparations and Method for Relieving Side Effects in Pergolide Therapy 审中-公开经皮制剂和缓解高效治疗副作用的方法公开(公告)号：US20080188509A1
公开(公告)日：2008-08-07
申请号：US12059106
申请日：2008-03-31
IPC分类号： A61K31/48
CPC分类号： A61K9/7061 , A61K9/7076 , A61K31/48
摘要： It is intended to provide pergolide-containing transdermal preparations having reduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and/or transdermal preparation containing pergolide and/or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A/B) of the maximum plasma level (A) of pergolide and/or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.
摘要翻译： 本发明旨在提供具有降低的副作用并发挥足够治疗效果的含pergolide的透皮制剂。 即，含有速溶胶的透皮制剂，能够实现速溶胶等的血浆AUC比例为1:0.5至1:5的至少一种pergolide代谢物; 和/或透皮制剂，其含有速溶胶和/或其药学上可接受的盐，其能够实现血浆白蛋白的最大血浆水平（A）和/或其药学上可接受的盐与血浆水平的比（A / B） B）在下一次给药时不到2次。
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公开(公告)号：US08691267B2
公开(公告)日：2014-04-08
申请号：US10525646
申请日：2003-08-07
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate-vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译： 一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和 碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。
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公开(公告)号：US20050260255A1
公开(公告)日：2005-11-24
申请号：US10525646
申请日：2003-08-07
IPC分类号： A61K9/70 , A61K31/405 , A61K31/4422 , A61K31/48 , A61K47/06 , A61K47/12 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate—vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译： 一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和 碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。
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公开(公告)号：US20070190123A1
公开(公告)日：2007-08-16
申请号：US10587832
申请日：2005-01-31
IPC分类号： A61F13/02
CPC分类号： A61K9/7084 , A61F2013/00646 , A61L15/44 , A61L2300/40 , A61L2300/608
摘要： The present invention provides a cover material 10, adapted to be attached to skin in a manner covering over the entirety of a patch 20, comprising a pressure-sensitive adhesive layer 12 on one side of a support 11, wherein said patch 20 comprises a drug-containing layer 22 for contacting with the skin, said layer being provided on a support film 21 with a thickness of 12-30 μm, and wherein the cover material 10 is adapted to be attached to said support film 21 and a region of the skin around said patch 20 in such a manner that the pressure-sensitive adhesive layer 12 contacts with the edges of the drug-containing layer 22, and the pressure-sensitive adhesive layer 12 comprises a pressure-sensitive adhesive obtained by polymerizing vinyl acetate or N-vinyl-2-pyrrolidone and a (meth)acrylic acid alkyl ester with a C8 alkyl group as essential monomer components. According to the invention, it is possible to provide a cover material capable of reducing irritation to an affected area such as skin when a patch employing a drug such as pergolide mesylate is covered and affixed to the affected area.
摘要翻译： 本发明提供了一种覆盖材料10，其适于以覆盖整个贴片20的方式附着到皮肤上，其包括在支撑体11的一侧上的压敏粘合剂层12，其中所述贴片20包括药物 容纳层22，用于与皮肤接触，所述层设置在厚度为12-30μm的支撑膜21上，并且其中覆盖材料10适于附着到所述支撑膜21和皮肤区域 围绕所述贴片20，使得压敏粘合剂层12与药物含有层22的边缘接触，并且压敏粘合剂层12包含通过聚合乙酸乙烯酯或N-乙烯基缩水甘油酯获得的压敏粘合剂， 乙烯基-2-吡咯烷酮和具有C8烷基作为必需单体成分的（甲基）丙烯酸烷基酯。 根据本发明，可以提供一种覆盖材料，其能够在使用药物例如甲磺酸格列德里特的贴剂覆盖并固定在受影响的区域时能够减少对患部的皮肤的刺激。
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公开(公告)号：US20060110433A1
公开(公告)日：2006-05-25
申请号：US10526065
申请日：2003-08-07
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive base agent and pergolide and/or a pharmaceutically acceptable salt thereof, wherein the adhesive base agent comprises an acrylic polymer including no substantial carboxyl group and hydroxyl group and having self-adhesion properties and a rubber polymer, and the weight ratio of the content of the acrylic polymer to the content of the rubber polymer is from 1:1 to 1:9.
摘要翻译： 一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂基剂和高氯代内酯和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂基剂包含不含实质性羧基和羟基的丙烯酸聚合物 并且具有自粘性和橡胶聚合物，并且丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:1至1:9。
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公开(公告)号：US20130053357A1
公开(公告)日：2013-02-28
申请号：US13643377
申请日：2011-04-27
IPC分类号： A61K31/575 , A61P17/00 , C07J9/00
CPC分类号： A61K31/137 , A61K9/7053 , A61K9/7061 , A61K31/138 , A61K31/343 , A61K31/407 , A61K31/465 , A61K31/517 , A61K47/28
摘要： Provided is a skin irritation suppressant for transdermal preparations, having a sufficient reduction effect of skin irritation due to a drug. Also provided is a transdermal preparation comprising the skin irritation suppressant. One embodiment of the invention is a skin irritation suppressant for suppressing the skin irritation due to a drug and a pharmaceutical ingredient to be used in a transdermal preparation other than the drug, the skin irritation suppressant comprising a sterol compound selected from the group consisting of cholesterol, cholesterol derivatives and cholesterol analogs, and the drug is one or more basic drugs selected from the group consisting of tolterodine, asenapine, bisoprolol, risperidone, nicotine and citalopram, and their pharmaceutically acceptable salts.
摘要翻译： 本发明提供一种透皮制剂的皮肤刺激抑制剂，具有充分的药物对皮肤刺激的降低作用。 还提供了包含皮肤刺激抑制剂的透皮制剂。 本发明的一个实施方案是用于抑制由药物引起的皮肤刺激的皮肤刺激抑制剂和用于除药物以外的透皮制剂中的药物成分，皮肤刺激抑制剂包含选自胆固醇的固醇化合物 胆固醇衍生物和胆固醇类似物，以及该药物是选自托特罗定，阿替那非，比索洛尔，利培酮，尼古丁和西酞普兰的一种或多种碱性药物及其药学上可接受的盐。
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公开(公告)号：US20080138388A1
公开(公告)日：2008-06-12
申请号：US11883672
申请日：2006-01-24
IPC分类号： A61K9/70 , A61K31/445 , A61P43/00
CPC分类号： A61K9/7061 , A61K31/445 , A61K31/454
摘要： It is intended to provide a transdermal absorption patch which is highly excellent in transdermal absorption properties and long-lasting drug effect even in the case where a drug-effect component contained in the transdermal absorption patch is a basic drug hardly soluble in a pressure-sensitive adhesive base, has a high stability of the drug contained therein with the passage of time and can achieve improvement in the compliance and simplification of the administration method. These problems can be solved by providing a transdermal absorption patch which contains a basic drug having an octanol/water partition coefficient (logarithm) in the free state of 3 or above, a pressure-sensitive adhesive base and a (meth)acrylic copolymer having carboxyl group.
摘要翻译： 旨在提供一种透皮吸收贴片，即使在经皮吸收贴剂中含有的药物作用成分是几乎不溶于压敏药物的碱性药物的情况下，其经皮吸收性能和持久的药物作用也非常优异 粘合剂基，随着时间的流逝，其中所含药物的稳定性高，并且可以提高施用方法的顺应性和简化性。 这些问题可以通过提供一种透皮吸收贴片来解决，该贴剂含有游离状态3以上的辛醇/水分配系数（对数），粘合剂基和具有羧基的（甲基）丙烯酸共聚物）的碱性药物 组。
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8.发明申请Transdermal preparations and method for relieving side effects in pergolide therapy 审中-公开透皮制剂和缓释百草苷治疗副作用的方法公开(公告)号：US20070082037A1
公开(公告)日：2007-04-12
申请号：US10577746
申请日：2004-10-29
CPC分类号： A61K9/7061 , A61K9/7076 , A61K31/48
摘要： It is intended to provide pergolide-containing transdermal preparations having reducreduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and/or transdermal preparation containing pergolide and/or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A/B) of the maximum plasma level (A) of pergolide and/or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.
摘要翻译： 旨在提供具有降低的副作用并施加足够治疗效果的含有pergolide的透皮制剂。 即，含有速溶胶的透皮制剂，能够实现速溶胶等的血浆AUC比例为1:0.5至1:5的至少一种pergolide代谢物; 和/或透皮制剂，其含有速溶胶和/或其药学上可接受的盐，其能够实现血浆白蛋白的最大血浆水平（A）和/或其药学上可接受的盐与血浆水平的比（A / B） B）在下一次给药时不到2次。
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公开(公告)号：US20130053358A1
公开(公告)日：2013-02-28
申请号：US13643427
申请日：2011-04-27
IPC分类号： A61K31/445 , A61P17/00 , A61P25/28 , A61K31/575
CPC分类号： A61K31/445 , A61K9/0014 , A61K9/7061
摘要： Provided is a transdermal preparation having low skin irritation as well as a sufficient skin permeability rate of donepezil, which comprises one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof. Also provided are a manufacturing method thereof, and a method for reducing skin irritation of a transdermally absorbable donepezil-containing preparation. An embodiment is a transdermal preparation comprising one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof, and a skin irritation-reducing agent.
摘要翻译： 提供具有低皮肤刺激性和多奈哌齐的足够的皮肤渗透速率的透皮制剂，其包含一种或多种选自多奈哌齐和其药学上可接受的盐的药物。 还提供了其制造方法和减少透皮吸收性多奈哌齐制剂的皮肤刺激的方法。 一个实施方案是包含一种或多种选自多奈哌齐和其药学上可接受的盐的药物和皮肤刺激减少剂的透皮制剂。
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公开(公告)号：US20090208560A1
公开(公告)日：2009-08-20
申请号：US12385935
申请日：2009-04-24
CPC分类号： A61K9/7084 , A61F2013/00646 , A61L15/44 , A61L2300/40 , A61L2300/608
摘要： A cover material adapted to cover the entirety of a patch is provided. The cover material has a support layer and, superimposed on a surface thereof, a pressure sensitive adhesive layer. The patch has a support film with a thickness of 12- to 30 μm and, superimposed thereon, a drug containing layer. The cover material may be attached to the surface of the support film and to the skin around the patch so that the pressure sensitive adhesive layer is brought into contact with edges of the drug containing layer. Additionally, the pressure sensitive adhesive layer contains an adhesive resulting from the polymerization of vinyl acetate or N-vinyl-2-pyrrolidone and a C8 alkyl (meth)acrylate as essential monomers. Thus, there is provided a cover material that, when a patch medicated with, for example, mesylic acid pergolide is fixed on diseased part, such as, a part of the skin, by covering the patch, is capable of reducing irritation, etc. on the diseased part.
摘要翻译： 提供适于覆盖整个贴片的覆盖材料。 覆盖材料具有支撑层，并且在其表面上叠加压敏粘合剂层。 该贴片具有厚度为12至30μm的支撑膜，并且叠加在其上的含药层。 覆盖材料可以附着到支撑膜的表面和贴片周围的皮肤，使得压敏粘合剂层与含药层的边缘接触。 此外，压敏粘合剂层包含由乙酸乙烯酯或N-乙烯基-2-吡咯烷酮和（甲基）丙烯酸C8烷基酯作为必需单体的聚合得到的粘合剂。 因此，提供了一种覆盖材料，其在例如通过覆盖片剂的情况下固定在患病部位（例如皮肤的一部分）上的情况下，能够减少刺激等。 在患病部位。
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