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公开(公告)号：US08580960B2
公开(公告)日：2013-11-12
申请号：US13181305
申请日：2011-07-12
IPC分类号： C07D239/48
CPC分类号： C07D239/48
摘要： A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
摘要翻译： 制备式k化合物或其盐或溶剂合物的方法，其中R1如本文所定义，该方法包括用氨处理式j化合物或其盐或溶剂合物，形成式k化合物。
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公开(公告)号：US20110269961A1
公开(公告)日：2011-11-03
申请号：US13181305
申请日：2011-07-12
IPC分类号： C07D239/48
CPC分类号： C07D239/48
摘要： A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
摘要翻译： 制备式k化合物或其盐或溶剂合物的方法，其中R1如本文所定义，该方法包括用氨处理式j化合物或其盐或溶剂合物，形成式k化合物。
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公开(公告)号：US07741484B2
公开(公告)日：2010-06-22
申请号：US11510208
申请日：2006-08-25
申请人： Anton Constantinescu , Keena Lynn Green , Eric Roy Humphreys , Gary R. Lee , Patrick Finbar McGarry
发明人： Anton Constantinescu , Keena Lynn Green , Eric Roy Humphreys , Gary R. Lee , Patrick Finbar McGarry
IPC分类号： C07D239/48
CPC分类号： C07D239/48
摘要： A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.
摘要翻译： 制备式I化合物的方法包括用碘化试剂处理式d化合物，以形成式I化合物，其中R 1，R 2和R 3如本文所定义。
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公开(公告)号：US07361648B2
公开(公告)日：2008-04-22
申请号：US11508581
申请日：2006-08-22
申请人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
发明人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
IPC分类号： A61K31/395 , A61K31/553 , A61K31/55
CPC分类号： C07D207/27 , A61K31/55 , A61K31/551 , A61K31/553 , C07D211/76 , C07D223/10 , C07D225/02 , C07D239/10 , C07D241/08 , C07D243/04 , C07D243/08 , C07D265/10 , C07D267/06 , C07D267/10 , C07D267/22 , C07D279/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译： 本发明涉及通常为毒蕈碱性M2 / M3受体拮抗剂并由式I表示的化合物：其中X，Y和Z为O，S或NR 5，其它取代基为 在规范中定义; 和前药，各异构体，异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。
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公开(公告)号：US06667301B2
公开(公告)日：2003-12-23
申请号：US09862286
申请日：2001-05-22
申请人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
发明人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
IPC分类号： C07D24108
CPC分类号： C07D207/27 , A61K31/55 , A61K31/551 , A61K31/553 , C07D211/76 , C07D223/10 , C07D225/02 , C07D239/10 , C07D241/08 , C07D243/04 , C07D243/08 , C07D265/10 , C07D267/06 , C07D267/10 , C07D267/22 , C07D279/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译： 本发明涉及通常为毒蕈碱性M2 / M3受体拮抗剂并由式I表示的化合物：其中X，Y和Z为O，S或NR 5，其它取代基如说明书中所定义; 和前药，各异构体，异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。
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公开(公告)号：US08003788B2
公开(公告)日：2011-08-23
申请号：US11906802
申请日：2007-10-04
IPC分类号： C07D239/48 , C07C43/20
CPC分类号： C07D239/48
摘要： A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
摘要翻译： 制备式k化合物或其盐或溶剂合物的方法，其中R1如本文所定义，该方法包括用氨处理式j化合物或其盐或溶剂合物，形成式k化合物。
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公开(公告)号：US20080086004A1
公开(公告)日：2008-04-10
申请号：US11906802
申请日：2007-10-04
IPC分类号： C07D239/02
CPC分类号： C07D239/48
摘要： A method for preparing a compound of formula k or a salt or solvate thereof, wherein R1 is as defined herein, the method comprising treating a compound of formula j or a salt or solvate thereof, with ammonia, to form the compound of formula k.
摘要翻译： 制备式k化合物或其盐或溶剂合物的方法，其中R 1如本文所定义，所述方法包括用氨，式I化合物或其盐或溶剂合物处理式 形成式k的化合物。
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公开(公告)号：US07094778B2
公开(公告)日：2006-08-22
申请号：US10685124
申请日：2003-10-14
申请人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
发明人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
IPC分类号： A61K31/513 , C07D279/06 , C07D413/12 , C07D239/10 , C07D241/08
CPC分类号： C07D207/27 , A61K31/55 , A61K31/551 , A61K31/553 , C07D211/76 , C07D223/10 , C07D225/02 , C07D239/10 , C07D241/08 , C07D243/04 , C07D243/08 , C07D265/10 , C07D267/06 , C07D267/10 , C07D267/22 , C07D279/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
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