公开(公告)号：US07306683B2

公开(公告)日：2007-12-11

申请号：US10827665

申请日：2004-04-19

申请人： Kenneth Man Chee Cheung ,  Kelvin Wai Kwok Yeung ,  William Weijia Lu ,  Chl Yuen Chung

发明人： Kenneth Man Chee Cheung ,  Kelvin Wai Kwok Yeung ,  William Weijia Lu ,  Chl Yuen Chung

IPC分类号： C22F1/10

CPC分类号： A61B17/866 ,  A61B17/72 ,  A61B17/80 ,  A61B17/842 ,  A61B2017/00867 ,  C22C19/03 ,  C22C30/00 ,  C22F1/006 ,  Y10T428/12

摘要： The present invention relates generally to a shape memory and/or super-elastic material, such as a nickel titanium alloy. Additionally or alternatively, the present invention relates to a super-elastic or pseudo-elastic material that has an initial transition temperature Af above a body temperature. The shape memory material can have a super-elasticity or pseudo-elasticity property at a temperature below the initial transition temperature Af of the material. For example, the shape memory material can have its workable temperature for producing super-elasticity or pseudo-elasticity of about 0° C. to 15° C. below the initial transition temperature Af. The shape memory material can be malleable at a room temperature, and become super-elastic or pseudo-elastic at a body temperature. In addition, the present invention relates to a method of making a shape memory or a super-elastic material. The treatment protocols can include but not limited to thermo-mechanical, thermo-mechanical, radiation, and ternary alloying treatments.

摘要翻译： 本发明一般涉及形状记忆和/或超弹性材料，例如镍钛合金。 另外或替代地，本发明涉及超弹性或假弹性材料，其具有高于体温的初始转变温度A 。 形状记忆材料可以在低于材料的初始转变温度A 的温度下具有超弹性或假弹性性质。 例如，形状记忆材料可具有用于产生低于初始转变温度A 的约0℃至15℃的超弹性或假弹性的可工作温度。 形状记忆材料可以在室温下延展，并且在体温下变得超弹性或假弹性。 此外，本发明涉及一种制作形状记忆或超弹性材料的方法。 处理方案可以包括但不限于热机械，热机械，辐射和三元合金化处理。

公开(公告)号：US20110166251A1

公开(公告)日：2011-07-07

申请号：US12836326

申请日：2010-07-14

申请人： Karen Hoi Man Wong ,  Kelvin Wai Kwok Yeung ,  Kenneth Man Chee Cheung ,  Keith Dip Kei Luk ,  John Kin On Lam ,  Paul Kim Ho Chu

发明人： Karen Hoi Man Wong ,  Kelvin Wai Kwok Yeung ,  Kenneth Man Chee Cheung ,  Keith Dip Kei Luk ,  John Kin On Lam ,  Paul Kim Ho Chu

IPC分类号： A61L27/44

CPC分类号： A61L27/58 ,  A61L27/446 ,  A61L2400/18 ,  C08L67/04

摘要： Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.

摘要翻译： 提供了新颖的混合材料及其制造方法。 新型混合材料可以包括可生物降解的聚合物和可生物降解的金属材料。 混合材料还可以包括可生物降解的金属材料和可生物降解的聚合物之间的偶联剂。 制造混合材料的方法可以包括对可生物降解的金属材料进行表面处理，然后进行溶剂形成法或热成形法。

公开(公告)号：US20110046747A1

公开(公告)日：2011-02-24

申请号：US12706483

申请日：2010-02-16

申请人： Kelvin Wai Kwok Yeung ,  Kenneth Man Chee Cheung ,  Keith Dip Kei Luk ,  Che Yan Yeung ,  Richard Yi Tsun Kao ,  Paul Kim Ho Chu

发明人： Kelvin Wai Kwok Yeung ,  Kenneth Man Chee Cheung ,  Keith Dip Kei Luk ,  Che Yan Yeung ,  Richard Yi Tsun Kao ,  Paul Kim Ho Chu

IPC分类号： A61F2/28

CPC分类号： A61L27/06 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/606 ,  C08L89/00

摘要： This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules. An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.

摘要翻译： 本发明涉及用于手术植入的等离子体处理和可控释放的抗微生物肽包被的钛合金，其中具有抗微生物性质的合金使用表面技术制造而不会不利地损害其生物相容性和原始机械性能。 表面技术在能够抵抗微生物粘附和增殖的合金上形成抗微生物层，同时当将合金植入人体时允许哺乳动物细胞粘附和增殖。 在一个实施方案中，应用PIII和D将离子，电子，自由基，原子或分子掺入钛合金基底上。 可以进行加压水热处理以建立用于抗微生物目的的反应性官能团或用于连接底物和外部抗微生物分子。 钛合金的最外层包括具有可控释放机构的抗菌肽，并且单独制造或在上述基础表面层的组装中制造。 可释放机制能够经受手术后的长期深部组织感染，并且在一个实施方案中包含作为连接分子的APTES。

公开(公告)号：US08444682B2

公开(公告)日：2013-05-21

申请号：US11853686

申请日：2007-09-11

申请人： Kelvin Wai Kwok Yeung ,  William Weijia Lu ,  Keith Dip Kei Luk ,  Kenneth Man Chee Cheung

发明人： Kelvin Wai Kwok Yeung ,  William Weijia Lu ,  Keith Dip Kei Luk ,  Kenneth Man Chee Cheung

IPC分类号： A61B17/86

CPC分类号： A61B17/7032 ,  A61B17/7034 ,  A61B2017/00867

摘要： A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials such as nickel-titanium (nitinol or NiTi) shape-memory-alloy, without the use of typical threaded fastening technique. Advantages are conferred by making the entire device, not just connecting pieces, out of shape memory alloy and having shape memory effect and super-elasticity. Heating the memory head of the device will compress the connection portion without the use of an auxiliary device (e.g. coupling member) so that the connection portion can be completely clamped down by the memory head. Further advantages are provided through the use of a two-way shape memory effect in which the memory device can be closed or tightened by heating up the ambient temperature, and re-opened by cooling down the temperature.

摘要翻译： 基于形状记忆效应和超弹性，已经开发了一种机构，用于连接诸如头部，脊柱，上肢和下肢之类的矫形植入物的支撑部分，从而防止在矫形植入物构造的植入物界面松动和微动。 的形状记忆材料如镍钛（镍钛诺或NiTi）形状记忆合金，而不使用典型的螺纹紧固技术。 通过将整个装置，不仅仅是连接件，形状记忆合金，并具有形状记忆效应和超弹性来赋予优点。 加热设备的存储头将不会使用辅助设备（例如，耦合构件）来压缩连接部分，使得连接部分可以被存储头完全夹紧。 通过使用双向形状记忆效应来提供进一步的优点，其中可以通过加热环境温度来关闭或紧固存储器件，并且通过冷却温度来重新打开。