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公开(公告)号：US20230324359A1
公开(公告)日：2023-10-12
申请号：US18300582
申请日：2023-04-14
发明人： Ken-ichi YAMADA , Saki SHINTO , Tomomi IDE , Keiichi YAMAMOTO
摘要： The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
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公开(公告)号：US11725002B2
公开(公告)日：2023-08-15
申请号：US16609028
申请日：2018-04-27
发明人： Ken-ichi Yamada , Tomomi Ide , Yuma Ishida , Go Ichien , Keiichi Yamamoto
IPC分类号： G01N21/64 , G01N21/78 , G01N33/533 , C07D413/12 , C07K16/18
CPC分类号： C07D413/12 , C07K16/18 , G01N21/6428 , G01N21/78 , G01N33/533
摘要： A detection reagent for comprehensively detecting an oxidized state and a glycated state of a low-density lipoprotein. While an oxidized low-density lipoprotein and a glycated low-density lipoprotein are detected with a fluolophore-labelled antibody, a lipid radical is detected with a fluorescent nitroxide 2,2,6-trimethyl-4-(4-nitrobenzo[1,2,5]oxadiazol-7-ylamino)-6-pentylpiperadine-1-oxyl (NBD-Pen).
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3.发明申请公开(公告)号：US20220096410A1
公开(公告)日：2022-03-31
申请号：US17422057
申请日：2020-01-09
发明人： Ken-ichi YAMADA , Saki SHINTO , Minato ISHIDA , Keiichi YAMAMOTO
IPC分类号： A61K31/198 , A61K45/06 , A61P27/02
摘要： The present invention may provide a pharmaceutical composition for intraocular administration or oral administration, for preventing or treating a retinal disease (such as age-related macular degeneration), or suppressing a progression of the disease in a subject in need of treatment, the composition comprising an effective amount of one or more compounds selected from the following group, and a pharmaceutically acceptable carrier; and a method therefor, a group consisting of apomorphine, eseroline, ethoxyquin, methyldopa, olanzapine and indapamide.
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4.发明申请公开(公告)号：US20180328951A1
公开(公告)日：2018-11-15
申请号：US15965096
申请日：2018-04-27
发明人： Ken-ichi YAMADA , Yuta MATSUOKA , Keiichi YAMAMOTO
CPC分类号： G01N33/92 , C07D271/12 , C11C1/002 , G01N33/582
摘要： [Problem] To provide a method of scavenging an unstable radical derived from a lipid and analyzing structures of those radicals.[Means for solution] A fluorescent nitroxide (NBD-Pen) is made to act to scavenge a lipid radical or a fragment radical thereof, and fluorescent detection liquid chromatography (LC/FL) and mass spectrometry (MS) are combined to identify lipid-derived radicals contained in a lipid extract.
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公开(公告)号：US20230324358A1
公开(公告)日：2023-10-12
申请号：US17979453
申请日：2022-11-02
发明人： Ken-ichi YAMADA , Saki SHINTO , Tomomi IDE , Keiichi YAMAMOTO
摘要： The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
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公开(公告)号：US11609238B2
公开(公告)日：2023-03-21
申请号：US15965096
申请日：2018-04-27
发明人： Ken-ichi Yamada , Yuta Matsuoka , Keiichi Yamamoto
IPC分类号： C07D413/12 , G01N33/92 , C11C1/00 , G01N33/58 , C11B1/10 , C07D271/12
摘要： [Problem] To provide a method of scavenging an unstable radical derived from a lipid and analyzing structures of those radicals.
[Means for solution] A fluorescent nitroxide (NBD-Pen) is made to act to scavenge a lipid radical or a fragment radical thereof, and fluorescent detection liquid chromatography (LC/FL) and mass spectrometry (MS) are combined to identify lipid-derived radicals contained in a lipid extract.-
公开(公告)号：US11519893B2
公开(公告)日：2022-12-06
申请号：US16628446
申请日：2018-07-05
发明人： Ken-ichi Yamada , Saki Shinto , Tomomi Ide , Keiichi Yamamoto
IPC分类号： G01N33/00 , G01N33/15 , C01G49/14 , C07C57/00 , C07D413/12 , C12N5/071 , C40B20/08 , G01N33/52
摘要： The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
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公开(公告)号：US20220023283A1
公开(公告)日：2022-01-27
申请号：US17421921
申请日：2020-01-09
发明人： Ken-ichi YAMADA , Keiichi YAMAMOTO
摘要： The disclosures as described herein a pharmaceutical composition for preventing or treating a cerebrovascular disorder or a vascular dementia, or suppressing a progression of the diseases in a subject in need of the treatment and so on, the composition comprising one or more compounds selected from the following group, and a pharmaceutically acceptable carrier; and a method using the same. A group consisting of apomorphine, eseroline, ethoxyquin, methyldopa, olanzapine, indapamide, and the others.
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公开(公告)号：US20200158709A1
公开(公告)日：2020-05-21
申请号：US16628446
申请日：2018-07-05
发明人： Ken-ichi YAMADA , Saki SHINTO , Tomomi IDE , Keiichi YAMAMOTO
摘要： The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
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