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1.发明授权Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines 失效通过四环素抑制哺乳动物肌肉的浪费和蛋白质降解
公开(公告)号：US5045538A
公开(公告)日：1991-09-03
申请号：US545395
申请日：1990-06-28
申请人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
发明人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).
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