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    Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
    8.
    发明授权
    Non-antibacterial tetracycline compositions of the prevention and treatment of root caries 失效
    非抗菌四环素组合物预防和治疗根龋

    公开(公告)号：US5770588A

    公开(公告)日：1998-06-23

    申请号：US591949

    申请日：1996-01-23

    申请人： Thomas F. McNamara ,  Lorne M. Golub ,  Nangavarum S. Ramamurthy

    发明人： Thomas F. McNamara ,  Lorne M. Golub ,  Nangavarum S. Ramamurthy

    IPC分类号： A61K31/65

    CPC分类号： A61Q11/00 ,  A61K31/65 ,  A61K8/42

    摘要： Methods of inhibiting root caries formation on mammalian tooth surfaces are disclosed. The methods include topically contacting the tooth root surfaces with an effective amount of a non-antibacterial tetracycline which is not systemically absorbed into the blood stream. In preferred embodiments, the tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth root surfaces.

    摘要翻译： 公开了抑制哺乳动物牙齿表面的根龋形成的方法。 所述方法包括将牙根表面与有效量的非全身吸收到血液中的非抗菌四环素进行局部接触。 在优选的实施方案中，四环素包括在各种口腔卫生产品如洁牙剂，锭剂，口香糖等中以接触牙根表面。

    Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
    10.
    发明授权
    Method for inhibiting expression of inducible nitric oxide synthase with tetracycline 失效
    用四环素抑制诱导型一氧化氮合酶表达的方法

    公开(公告)号：US5919775A

    公开(公告)日：1999-07-06

    申请号：US61286

    申请日：1998-04-16

    申请人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    发明人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    IPC分类号： A61K31/65 ,  A61P13/12 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00

    CPC分类号： A61K31/65

    摘要： The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

    摘要翻译： 本发明是一种在体内，体外或离体生物体系中抑制一氧化氮（NO）的产生的方法。 该方法采用四环素化合物抑制NO的产生和/或抑制一氧化氮合酶（iNOS）的诱导型异构体的表达或活性。 优选地，四环素化合物对金属蛋白酶具有抑制活性。 此外，优选的是，四环素化合物以系统中几乎没有或没有抗菌活性的量提供给生物系统。 因此，优选的四环素化合物是四环素化合物，其被修饰以降低或消除其抗微生物活性。 该方法可用于治疗以iNOS介导的NO产生为特征的哺乳动物的医疗状况，包括例如炎性病症。