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1.发明授权Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines 失效通过四环素抑制哺乳动物肌肉的浪费和蛋白质降解
公开(公告)号：US5045538A
公开(公告)日：1991-09-03
申请号：US545395
申请日：1990-06-28
申请人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
发明人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).
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2.发明授权Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines 失效抑制过量磷脂酶A2活性和/或非抗微生物四环素生产
公开(公告)号：US6043231A
公开(公告)日：2000-03-28
申请号：US115158
申请日：1993-08-31
申请人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
发明人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , Y10S514/825 , Y10S514/863 , Y10S514/895
摘要： A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production is disclosed. A pharmaceutical composition is also disclosed.
摘要翻译： 公开了一种治疗患有与过量磷脂酶A2活性和/或产物相关的病症的哺乳动物的方法，包括向哺乳动物施用有效量的足以抑制过量磷脂酶A2活性和/或产生的非抗微生物四环素。 还公开了药物组合物。
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3.发明授权Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss 失效包含吲哚美辛[非甾体抗炎剂]和有效的非抗菌四环素以减少骨丢失的组合物
公开(公告)号：US5459135A
公开(公告)日：1995-10-17
申请号：US200415
申请日：1994-02-23
IPC分类号： A61K31/19 , A61K31/215 , A61K31/54 , A61K31/60 , A61K31/65 , A61K45/06 , A61P1/02 , A61P3/00 , A61P17/00 , A61P19/10 , A61P27/02 , A61P29/00 , A61P43/00 , A61K31/40
CPC分类号： A61K31/65 , Y10S514/825
摘要： A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
摘要翻译： 用于治疗患有类风湿性关节炎和与过量金属蛋白酶活性相关的其它组织破坏性（慢性炎症或其他）病症的哺乳动物的方法，包括向哺乳动物施用一定量的有效抗金属蛋白酶的四环素，但不能有效地抗微生物， 和一定量的非甾体抗炎剂，当与有效的抗金属蛋白酶量的四环素组合时，导致组织破坏和/或骨丢失的显着减少。
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公开(公告)号：US5258371A
公开(公告)日：1993-11-02
申请号：US891554
申请日：1992-05-29
申请人： Lorne M. Golub , Nangavarum S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Tsutomu Kawai , Takashi Hamasaki , Michiya Shimamura , Goro Kobayashi , Tetsuo Takigawa , Hisashi Iwata
发明人： Lorne M. Golub , Nangavarum S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Tsutomu Kawai , Takashi Hamasaki , Michiya Shimamura , Goro Kobayashi , Tetsuo Takigawa , Hisashi Iwata
IPC分类号： A61K31/65 , A61P19/02 , A61P29/00 , A61P43/00 , C07C235/40 , C07C237/26
CPC分类号： A61K31/65 , Y10S514/825
摘要： Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula ##STR1## The method is effective in the treatment of various articular diseases characterized by excessive collagen destruction.
摘要翻译： 本发明提供一种治疗患有特征在于过度胶原破坏的病症或疾病的人或动物的方法，其包括向所述人或动物施用有效量的由以下通式表示的12a-脱氧四环素：该方法是有效的 用于治疗以胶原蛋白破坏过多为特征的各种关节疾病。
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5.发明授权Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines 失效抑制过量磷脂酶A2活性和/或非抗微生物四环素生产
公开(公告)号：US5523297A
公开(公告)日：1996-06-04
申请号：US426899
申请日：1995-04-21
申请人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
发明人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production is disclosed.
摘要翻译： 公开了一种治疗患有与过量磷脂酶A2活性和/或产物相关的病症的哺乳动物的方法，包括向哺乳动物施用有效量的足以抑制过量磷脂酶A2活性和/或产生的非抗微生物四环素。
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6.发明授权Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss 失效组合物包含氟妥波洛和有效的非抗菌四环素以减少骨丢失
公开(公告)号：US5321017A
公开(公告)日：1994-06-14
申请号：US743579
申请日：1991-08-12
IPC分类号： A61K31/19 , A61K31/215 , A61K31/54 , A61K31/60 , A61K31/65 , A61K45/06 , A61P1/02 , A61P3/00 , A61P17/00 , A61P19/10 , A61P27/02 , A61P29/00 , A61P43/00 , A61K31/40
CPC分类号： A61K31/65 , Y10S514/825
摘要： A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
摘要翻译： 用于治疗患有类风湿性关节炎和与过量金属蛋白酶活性相关的其它组织破坏性（慢性炎症或其他）病症的哺乳动物的方法，包括向哺乳动物施用一定量的有效抗金属蛋白酶的四环素，但不能有效地抗微生物， 和一定量的非甾体抗炎剂，当与有效的抗金属蛋白酶量的四环素组合时，导致组织破坏和/或骨丢失的显着减少。
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7.发明授权Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline 失效组合物包含非甾体抗炎剂tenidap和有效的非抗菌四环素
公开(公告)号：US5308839A
公开(公告)日：1994-05-03
申请号：US940540
申请日：1992-09-04
IPC分类号： A61K31/19 , A61K31/195 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K31/65 , A61K45/00 , A61P29/00 , A61P43/00
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of a non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
摘要翻译： 用于治疗患有类风湿性关节炎，其他组织破坏性病症的哺乳动物和与过量金属蛋白酶活性相关的慢性炎症或其它病症的方法，其包括向哺乳动物施用一定量的有效抗金属蛋白酶的四环素，但不是有效的抗微生物 和一定量的非甾体抗炎剂，当与四环素的有效抗金属蛋白酶量组合时，导致组织破坏和/或骨丢失的显着降低。
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8.发明授权
公开(公告)号：US5770588A
公开(公告)日：1998-06-23
申请号：US591949
申请日：1996-01-23
IPC分类号： A61K31/65
摘要： Methods of inhibiting root caries formation on mammalian tooth surfaces are disclosed. The methods include topically contacting the tooth root surfaces with an effective amount of a non-antibacterial tetracycline which is not systemically absorbed into the blood stream. In preferred embodiments, the tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth root surfaces.
摘要翻译： 公开了抑制哺乳动物牙齿表面的根龋形成的方法。 所述方法包括将牙根表面与有效量的非全身吸收到血液中的非抗菌四环素进行局部接触。 在优选的实施方案中，四环素包括在各种口腔卫生产品如洁牙剂，锭剂，口香糖等中以接触牙根表面。
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9.发明授权Non-antibacterial tetracycline compositions possessing antiplaque properties 失效非抗菌TETRACYCLINE组合物抗静电性能
公开(公告)号：US5223248A
公开(公告)日：1993-06-29
申请号：US654073
申请日：1991-02-11
摘要： A method of inhibiting plaque formation on mammalian tooth surfaces is disclosed. The method includes contacting the tooth surfaces with an effective amount of a non-antibacterial tetracycline. In a preferred embodiment, such tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth surfaces and prevent plaque accumulation thereon.
摘要翻译： 公开了一种抑制哺乳动物牙齿表面形成斑块的方法。 该方法包括使牙齿表面与有效量的非抗菌四环素接触。 在优选的实施方案中，这些四环素包括在各种口腔卫生产品如洁齿剂，锭剂，口香糖等中以接触牙齿表面并防止其上积累斑块。
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