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1.发明授权Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods 失效来自腰果的纯化的线性表位，编码它们的核酸以及相关方法公开(公告)号：US07538203B1
公开(公告)日：2009-05-26
申请号：US11096911
申请日：2005-04-01
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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2.发明授权Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods 失效来自腰果的纯化的线性表位，编码它们的核酸以及相关方法公开(公告)号：US07381534B1
公开(公告)日：2008-06-03
申请号：US11096910
申请日：2005-04-01
IPC分类号： A61K38/00 , A61K38/04 , G01N33/53 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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3.发明授权Purified linear epitopes from cashew nuts, nucleic acids encoding therefor and associated methods 失效来自腰果的纯化的线性表位，其编码的核酸和相关方法公开(公告)号：US08273856B2
公开(公告)日：2012-09-25
申请号：US12466565
申请日：2009-05-15
IPC分类号： C07K1/00
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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公开(公告)号：USRE42324E1
公开(公告)日：2011-05-03
申请号：US12757821
申请日：2010-04-09
申请人： Sylvia Laffer , Erik Hogbom , Kenneth H. Roux , Jonas Adriansson , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Hans Grönlund , Rudolf Valenta
发明人： Sylvia Laffer , Erik Hogbom , Kenneth H. Roux , Jonas Adriansson , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Hans Grönlund , Rudolf Valenta
IPC分类号： A61K39/395 , C12P21/08 , C07K16/42 , C07K19/00
CPC分类号： C07K16/16 , A61K2039/505 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to a novel drug candidate having a potential for universal therapy of allergy and asthma.The invention provides a Fab (antibody fragment), having the following characteristics: a) inhibits the IgE-FcεRI interaction; b) binds to free and cell-bound IgE; and c) is non-anaphylactic.
摘要翻译： 本发明涉及一种具有普遍治疗过敏和哮喘潜力的新型候选药物。 本发明提供具有以下特征的Fab（抗体片段）：a）抑制IgE-Fc和RI的相互作用; b）结合游离和细胞结合的IgE; 和c）是非过敏性的。
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5.发明授权公开(公告)号：US07250489B2
公开(公告)日：2007-07-31
申请号：US10251918
申请日：2002-09-20
CPC分类号： C07K14/415 , A61K39/00 , G01N33/564
摘要： A purified Ig-E binding immunogenic polypeptide the amino acid sequence of which consists of SEQ ID NO:1 is disclosed. The purified amino acid sequence is a major allergen of the walnut Juglans regia. Also described are a diagnostic test kit and use of the purified polypeptide in tests for identifying patients having an allergy to walnuts. Mutations of the disclosed polypeptide, as well as nucleic acid sequences encoding therefor are claimed as part of the invention.
摘要翻译： 公开了由SEQ ID NO：1组成的氨基酸序列的纯化的Ig-E结合免疫原性多肽。 纯化的氨基酸序列是核桃胡桃核桃的主要变应原。 还描述了诊断测试试剂盒和在用于鉴定对核桃过敏的患者的测试中使用纯化的多肽。 公开的多肽的突变以及编码的核酸序列被要求保护作为本发明的一部分。
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公开(公告)号：US06986889B2
公开(公告)日：2006-01-17
申请号：US10108301
申请日：2002-03-28
申请人： Sylvia Laffer , Erik Högbom , Kenneth H. Roux , Jonas Adriansson , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Hans Grönlund , Rudolf Valenta
发明人： Sylvia Laffer , Erik Högbom , Kenneth H. Roux , Jonas Adriansson , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Hans Grönlund , Rudolf Valenta
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C12P21/08
CPC分类号： C07K16/16 , A61K2039/505 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to a novel drug candidate having a potential for universal therapy of allergy and asthma.The invention provides a Fab (antibody fragment), having the following characteristics: a) inhibits the IgE-FcεRI interaction; b) binds to free and cell-bound IgE; and c) is non-anaphylactic.
摘要翻译： 本发明涉及一种具有普遍治疗过敏和哮喘潜力的新型候选药物。 本发明提供具有以下特征的Fab（抗体片段）：a）抑制IgE-FcepsilonRI相互作用; b）结合游离和细胞结合的IgE; 和c）是非过敏性的。
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7.发明授权Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods 失效来自腰果的纯化的线性表位，编码它们的核酸以及相关方法公开(公告)号：US06884877B2
公开(公告)日：2005-04-26
申请号：US10264303
申请日：2002-10-03
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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公开(公告)号：US08114605B1
公开(公告)日：2012-02-14
申请号：US12025875
申请日：2008-02-05
IPC分类号： G01N33/53
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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9.发明授权公开(公告)号：US08007770B1
公开(公告)日：2011-08-30
申请号：US12842575
申请日：2010-07-23
CPC分类号： C07K14/415 , A61K39/00 , G01N33/564
摘要： A purified Ig-E binding immunogenic polypeptide the amino acid sequence of which consists of SEQ ID NO:1 is disclosed. The purified amino acid sequence is a major allergen of the walnut Juglans regia. Also described are a diagnostic test kit and use of the purified polypeptide in tests for identifying patients having an allergy to walnuts. Mutations of the disclosed polypeptide, as well as nucleic acid sequences encoding therefor are claimed as part of the invention.
摘要翻译： 公开了由SEQ ID NO：1组成的氨基酸序列的纯化的Ig-E结合免疫原性多肽。 纯化的氨基酸序列是核桃胡桃核桃的主要变应原。 还描述了诊断测试试剂盒和在用于鉴定对核桃过敏的患者的测试中使用纯化的多肽。 公开的多肽的突变以及编码的核酸序列被要求保护作为本发明的一部分。
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10.发明申请Purified Linear Epitopes From Cashew Nuts, Nucleic Acids Endcoding Therefor And Associated Methods 失效来自腰果的纯化线性表位，其核苷酸及其相关方法公开(公告)号：US20100311603A1
公开(公告)日：2010-12-09
申请号：US12466565
申请日：2009-05-15
IPC分类号： C40B30/04 , C07K14/415 , C07H21/04
CPC分类号： C07K14/415 , A61K38/10 , A61K38/168 , A61K45/06 , A61K49/0004 , C07K7/08 , G01N33/6854 , G01N2333/415 , Y10S435/81
摘要： Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
摘要翻译： 披露了腰果中的主要过敏原蛋白，其是豆科蛋白样蛋白和2S白蛋白。 还公开了7S超家族中的多肽过敏原，其包括vicilin样和蔗糖结合蛋白。 确定和表征腰果的几个线性表位。 本发明进一步公开了编码变应原性多肽的cDNA序列，变应原命名为Ana o1，并描述了表达的重组多肽的表征和使用该多肽的相关方法。
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