公开(公告)号：US07104594B2

公开(公告)日：2006-09-12

申请号：US10910137

申请日：2004-08-03

申请人： Sean Elliot Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Enrico Milani ,  Gary Hawkins

发明人： Sean Elliot Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Enrico Milani ,  Gary Hawkins

IPC分类号： B60R13/02

CPC分类号： B60R13/04 ,  B62D25/163 ,  B62D29/048 ,  Y10T24/309

摘要： A clip assembly mounts a cladding panel to a body. The clip assembly includes a clip and a key guide. The clip has a head and a shaft. The head is adapted for attaching to a flange of the cladding panel. The key guide has a hollow body sized to receive and retain the shaft in a first and second engagement position. The key guide is configured to be inserted into a slot on the body structure and upon rotation is retained within the slot. One end of the cladding engages the pilot aperture and an opposite end engages a slot. The cladding is adjustable relative to the body structure while in a first engagement position and is held in place for further fastening when in a second engagement position.

摘要翻译： 夹子组件将覆盖面板安装到主体上。 夹子组件包括夹子和钥匙引导件。 夹子有一个头部和一个轴。 头部适于附接到包层板的凸缘。 钥匙引导件具有中空体，其尺寸适于在第一和第二接合位置接收和保持该轴。 钥匙导轨配置成插入车身结构的槽中，并且旋转时保持在槽内。 包层的一端与引导孔接合，并且相对的一端接合槽。 当处于第一接合位置时，包层可相对于主体结构调节，并且当处于第二接合位置时被保持就位以进一步紧固。

公开(公告)号：US06933150B1

公开(公告)日：2005-08-23

申请号：US09584586

申请日：2000-05-31

申请人： Brian Sorrentino ,  Kevin Bunting ,  John Schuetz ,  Hiromitsu Nakauchi

发明人： Brian Sorrentino ,  Kevin Bunting ,  John Schuetz ,  Hiromitsu Nakauchi

IPC分类号： A61K35/12 ,  A61K48/00 ,  C07K14/705 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574 ,  C12N5/00 ,  C12N5/08 ,  C12N15/63 ,  C12N15/85 ,  C12N15/87

CPC分类号： G01N33/5005 ,  A61K48/00 ,  A61K2035/124 ,  C07K14/705 ,  C12N2799/022 ,  C12N2799/027 ,  G01N33/56966 ,  G01N33/57426

摘要： The present invention includes methods of performing ex vivo expansion of gene-modified hematopoietic stem cells which are useful for many applications involving bone marrow transplantation and ex vivo gene therapy. The present invention further includes the gene-modified hematopoietic stem cells that are used and produced by such methods. Such gene-modified hematopoietic stem cells can also contain a second heterologous gene. In addition, the present invention also includes methods of engrafting the gene-modified hematopoietic stem cells of the present invention into animals, including for ex vivo gene therapy and for reconstitution of hematopoietic cells in ablated mammals. The present invention also provides a method of isolating stem cells.

摘要翻译： 本发明包括用于涉及骨髓移植和离体基因治疗的许多应用的基因修饰的造血干细胞的离体扩增的方法。 本发明还包括通过这些方法使用和生产的基因修饰的造血干细胞。 这种基因修饰的造血干细胞还可以含有第二异源基因。 此外，本发明还包括将本发明的基因修饰的造血干细胞移植到动物中的方法，包括用于离体基因治疗和烧伤的哺乳动物中的造血细胞的重构。 本发明还提供了一种分离干细胞的方法。

公开(公告)号：US06811210B2

公开(公告)日：2004-11-02

申请号：US10381071

申请日：2003-03-19

申请人： Sean Elliot Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Enrico Milani ,  Gary Hawkins

发明人： Sean Elliot Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Enrico Milani ,  Gary Hawkins

IPC分类号： B60R1302

CPC分类号： B60R13/04 ,  B62D29/048 ,  Y10T24/309

摘要： A clip assembly (36, 60) mounts a cladding panel to a body. The clip assembly includes a clip (36) and a key guide (60). The clip (36) has a head (38) and a shaft (40). The head (38) is adapted for attaching to a flange of the cladding panel. The key guide (60) has a hollow body (62) sized to receive and retain the shaft (40) in a first and second engagement position. The key guide (60) is configured to be inserted into a slot (52, 56) on the body structure and upon rotation is retained within the slot. One end of the cladding engages the pilot aperture (56) and an opposite end engages a slot (52). The cladding is adjustable relative to the body structure while in a first engagement position and is held in place for further fastening when in a second engagement position.

公开(公告)号：US20050006927A1

公开(公告)日：2005-01-13

申请号：US10910137

申请日：2004-08-03

申请人： Sean Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Milani ,  Gary Hawkins

发明人： Sean Granger ,  John Hobill ,  Kevin Bunting ,  Michael Gach ,  Adolfo Milani ,  Gary Hawkins

IPC分类号： B60R13/04 ,  B62D25/16 ,  B62D29/04 ,  B62D25/00

CPC分类号： B60R13/04 ,  B62D25/163 ,  B62D29/048 ,  Y10T24/309

摘要： A clip assembly mounts a cladding panel to a body. The clip assembly includes a clip and a key guide. The clip has a head and a shaft. The head is adapted for attaching to a flange of the cladding panel. The key guide has a hollow body sized to receive and retain the shaft in a first and second engagement position. The key guide is configured to be inserted into a slot on the body structure and upon rotation is retained within the slot. One end of the cladding engages the pilot aperture and an opposite end engages a slot. The cladding is adjustable relative to the body structure while in a first engagement position and is held in place for further fastening when in a second engagement position.

摘要翻译： 夹子组件将覆盖面板安装到主体上。 夹子组件包括夹子和钥匙引导件。 夹子有一个头部和一个轴。 头部适于附接到包层板的凸缘。 钥匙引导件具有中空体，其尺寸适于在第一和第二接合位置接收和保持该轴。 钥匙导轨配置成插入车身结构的槽中，并且旋转时保持在槽内。 包层的一端与引导孔接合，并且相对的一端接合槽。 当处于第一接合位置时，包层可相对于主体结构调节，并且当处于第二接合位置时被保持就位以进一步紧固。