公开(公告)号：US06506904B1

公开(公告)日：2003-01-14

申请号：US10152118

申请日：2002-05-21

申请人： Seung-Hwan Kim ,  Jeong-Ho Park ,  Jin-Man Kim ,  Soon-Jong Hahn ,  Ki-Seong Choi ,  Myung-Ho Cho

发明人： Seung-Hwan Kim ,  Jeong-Ho Park ,  Jin-Man Kim ,  Soon-Jong Hahn ,  Ki-Seong Choi ,  Myung-Ho Cho

IPC分类号： C07D27503

CPC分类号： C07D275/03 ,  C07C319/20 ,  C07C319/24 ,  C07C323/60

摘要： A method of preparing N,N-disubstituted 3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropi-onamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and N-substituted-3-mercaptopropionamide reacts with an aqueous solution of hydrogen peroxide. In addition, a method of preparing substituted 3-isothiazolone is provided. In the method, the produced N,N-disubstituted-3,3′-dithiodipropionamide reacts with a halogenating agent, wherein X and Z are same or different and each selected from the group consisting of hydrogen or a lower alkyl group; Y is selected from the group consisting of hydrogen, an alkyl group of 1 to 18 carbon atoms, a cycloalkyl group of up to 10 carbon atoms, an aralkyl group of up to 10 carbon atoms, an alkyl group of up to 10 carbon atoms, a halogen-, lower alkyl- or lower alkoxy-substituted aryl group, cyano alkyl group, a carboalkoxyalkyl group, a haloalkyl group, an alkoxyalkyl group, an aryloxyalkyl group of up to 12 carbon atoms, an aralkoxyalkyl group of up to 12 carbon atoms, a dialkylaminoalkyl group, an alkylacyl group of up to 8 carbon atoms, a lower alkylsulfonyl group, an arylsulfonyl group of up to 10 carbon atoms, a cyano group and a carbamoyl group.

摘要翻译： 提供了制备式（2）的N，N-二取代的3,3'-二硫代二丙酰胺的方法。 在该方法中，式（4）的3-巯基丙酰胺与胺水溶液反应制备式（3）的N-取代-3-巯基丙酰胺，N-取代-3-巯基丙酰胺与过氧化氢水溶液 。 此外，提供了制备取代的3-异噻唑酮的方法。 在该方法中，所制备的N，N-二取代-3,3'-二硫代二丙酰胺与卤化剂反应，其中X和Z相同或不同，各自选自氢或低级烷基; Y选自氢，1至18个碳原子的烷基，至多10个碳原子的环烷基，至多10个碳原子的芳烷基，至多10个碳原子的烷基， 卤素，低级烷基或低级烷氧基取代的芳基，氰基烷基，碳烷氧基烷基，卤代烷基，烷氧基烷基，至多12个碳原子的芳氧基烷基，至多12个碳原子的芳烷氧基烷基 ，二烷基氨基烷基，至多8个碳原子的烷基酰基，低级烷基磺酰基，至多10个碳原子的芳基磺酰基，氰基和氨基甲酰基。