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公开(公告)号:US20120108799A1
公开(公告)日:2012-05-03
申请号:US13227286
申请日:2011-09-07
CPC分类号: C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/344 , C12N2310/352 , C12N2310/3529 , C12N2320/51 , C12Q1/6876
摘要: The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.
摘要翻译: 本发明涉及反义寡核苷酸的修饰,其中所述修饰用于改善稳定性并提供对核酸酶降解的保护。 这些修饰也可以并入双链核酸,如合成siRNA和miRNA。