公开(公告)号：US20090306454A1

公开(公告)日：2009-12-10

申请号：US12083586

申请日：2006-05-03

申请人： Kimberly P. Cockerham ,  Harvey A. Fishman ,  Anthony Liu ,  Alissa M. Fitzgeral ,  Dorian Liepmann ,  Benjamin W. Chul ,  Michael F. Marmor ,  Wentai Liu ,  Juan G. Santiago

发明人： Kimberly P. Cockerham ,  Harvey A. Fishman ,  Anthony Liu ,  Alissa M. Fitzgeral ,  Dorian Liepmann ,  Benjamin W. Chul ,  Michael F. Marmor ,  Wentai Liu ,  Juan G. Santiago

IPC分类号： A61N1/36 ,  A61N2/00

CPC分类号： A61N1/36067 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/36017 ,  A61N1/36046 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/3787

摘要： Devices, systems and methods are provided for directly stimulating tissues, particularly muscle tissues, to modulate muscle contractions (i.e. provide reanimation of the muscle or to suppress undesired muscle contractions). Reanimation of muscles may be desired when damage to the brain, nervous system or neuromuscular junctions have occurred, causing a muscle tissue to lack sufficient motor control. Suppression of muscle contractions may be desired in situations of pathologically hyperactive muscles, such as in conditions of muscle spasm (e.g. blepharospasm and hemifacial spasm) or muscle dystonia. Direct stimulation is achieved by delivering a chemical agent directly to the muscle tissue, particularly the motor end plate, bypassing the nerves and neuromuscular junctions which may be damaged or diseased. Implanted hybrid chemical and electromagnetic stimulation devices can modulate muscle contraction in response to signals from a controller.

摘要翻译： 提供装置，系统和方法用于直接刺激组织，特别是肌肉组织，以调节肌肉收缩（即，提供肌肉的再生或抑制不需要的肌肉收缩）。 当发生对脑，神经系统或神经肌肉接头的损伤时，可能需要恢复肌肉，导致肌肉组织缺乏足够的运动控制。 在病理性活动过度肌肉的情况下，例如肌肉痉挛（例如睑痉挛和半面肌痉挛）或肌肉肌张力障碍的情况下，可能需要抑制肌肉收缩。 直接刺激通过将化学药剂直接递送到肌肉组织，特别是马达端板，绕过可能被损坏或患病的神经和神经肌肉接头来实现。 植入式混合化学和电磁刺激装置可以响应于来自控制器的信号来调节肌肉收缩。