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公开(公告)号：US4680413A
公开(公告)日：1987-07-14
申请号：US814893
申请日：1985-12-30
IPC分类号： C07D207/34 , C07D405/04 , C07D207/22
CPC分类号： C07D405/04 , C07D207/34
摘要： A process for the production of a compound having the formula: ##STR1## which comprises a reaction of a compound having the formula: ##STR2## with a compound having the formulaR.sup.2 SO.sub.2 CH.sub.2 NCwhereinX is same or different substituent(s) selected from the group consisting of halogen, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 alkylamino, C.sub.1-6 alkoxy, nitro, cyano and methylenedioxy;COOR.sup.1 is carboxylic acid or ester;R.sup.2 is C.sub.1-10 cyclic hydrocarbon which may be substituted by substituent(s) not giving negative effects to said reaction;n is 0, 1 or 2.
摘要翻译： 制备具有下式的化合物的方法：包括具有下式的化合物与下式的化合物的反应：其中X是相同或不同的选自下列基团的取代基： 由卤素，C 1-6烷基，C 1-6卤代烷基，C 1-6烷基氨基，C 1-6烷氧基，硝基，氰基和亚甲二氧基组成。 COOR1是羧酸或酯; R2是可以被不对所述反应产生负面影响的取代基取代的C1-10环烃; n为0,1或2。
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公开(公告)号：US4985575A
公开(公告)日：1991-01-15
申请号：US475801
申请日：1990-02-06
申请人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Kiyoharu Nakayama , Osamu Miyahara , Kenichi Noguchi
发明人： Masaji Ishiguro , Hiromitsu Iwata , Takashi Nakatsuka , Kiyoharu Nakayama , Osamu Miyahara , Kenichi Noguchi
IPC分类号： C07B57/00 , C07D307/24
CPC分类号： C07D307/24
摘要： A process for preparing an optically active tetrahydro-2-furoic acid is disclosed. The process comprises (i) reacting (.+-.)-tetrahydro-2-furoic acid with an optically active amine resolver of the following formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group and R.sub.2 represents an alkyl group or ar aryl group, provided that R.sub.1 and R.sub.2 are different from each other, thus producing an optically active diastereomer salt, and (ii) decomposing the diastereomer salt. According to the process, a high purity, optically active tetrahydro-2-furoic acid can be prepared at a high yield using an amine resolver. The amine resolver can be recovered at a high yield and high purity.
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