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公开(公告)号：US09335330B2
公开(公告)日：2016-05-10
申请号：US12456037
申请日：2009-06-10
Applicant: Knut Johansen
Inventor： Knut Johansen
CPC classification number: G01N33/6893 , G01N2800/324
Abstract: A method to extract information from samples taken at different times from a mammalian. These samples are analyzed with respect to one or more analytes giving one or more responses, creating one or more response curves. From this/these response curves is/are changes in the responses calculated as slope, curvatures or mathematical functions. This is especially useful for early detection of acute myocardial infarction.
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公开(公告)号：US06862094B2
公开(公告)日：2005-03-01
申请号：US10220304
申请日：2001-03-14
Applicant: Knut Johansen
Inventor： Knut Johansen
CPC classification number: G01N21/553
Abstract: A two-dimensional imaging surface plasmon resonance (SPR) apparatus for optical surface analysis of a sample area on a sensor surface is disclosed. The apparatus comprises a sensor surface layer of a conductive material that can support a surface plasmon, such as a free electron metal, e.g. gold, silver or aluminum, a source of electromagnetic beams of two or more wavelengths that illuminate a two-dimensional surface area from either the front or the backside of the sensor surface layer, and a detector for simultaneous, or pseudo simultaneous, detection of two or more wavelengths of reflected intensities from the two-dimensional surface area, providing two or more two-dimensional images of the surface area, the two-dimensional images being a function of the effective refractive index at each point on the surface area. The two-dimensional images put together result in a color image. The apparatus is suitable for use in biological, biochemical, chemical and physical testing.
Abstract translation: 公开了一种用于传感器表面上的样品区域的光学表面分析的二维成像表面等离子体共振（SPR）装置。 该装置包括能够支撑表面等离子体的导电材料的传感器表面层，例如自由电子金属，例如， 金，银或铝，两个或更多个波长的电磁波源，其照射来自传感器表面层的前侧或背面的二维表面区域，以及用于同时或伪同时检测两个 或更多的来自二维表面区域的反射强度的波长，提供表面积的两个或更多个二维图像，二维图像是表面区域上每个点处的有效折射率的函数。 放在一起的二维图像产生彩色图像。 该设备适用于生物，生化，化学和物理测试。
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公开(公告)号：US08149411B2
公开(公告)日：2012-04-03
申请号：US12447825
申请日：2007-10-29
Applicant: Knut Johansen , Mats Rånby
Inventor： Knut Johansen , Mats Rånby
CPC classification number: G01N21/553 , G01N21/03 , G01N2021/0307 , G01N2021/0346
Abstract: The invention relates to a sensor unit for a Surface Plasmon Resonance (SPR) unit, comprising a transparent sensor structure forming at least one wall of a cavity, the wall being defined by a concave inner surface and a convex outer surface The inner surface is provided with a layer of a conductive material capable of supporting a surface plasmon. In the cavity there is provided a flow structure in said cavity so as to form at least one compartment for sample between the flow structure and the inner wall of the cavity. Also, a method for the detection of events at a surface by utilizing surface plasmon resonance is provided. It comprises placing a sample with an analyte of interest in a sensor unit as claimed in claim 1, and measuring the reflectance from said sensor unit at a single or plurality of angle/angles.
Abstract translation: 本发明涉及一种用于表面等离子体共振（SPR）单元的传感器单元，其包括形成空腔的至少一个壁的透明传感器结构，该壁由凹内表面和凸形外表面限定。内表面设置 具有能够支撑表面等离子体激元的导电材料层。 在空腔中，在所述空腔中设置有流动结构，以便在流动结构和空腔的内壁之间形成用于样品的至少一个隔室。 另外，提供了利用表面等离子共振来检测表面的事件的方法。 其包括将具有感兴趣的分析物的样品放置在如权利要求1所述的传感器单元中，并且以单个或多个角度/角度测量来自所述传感器单元的反射率。
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公开(公告)号：US20100271632A1
公开(公告)日：2010-10-28
申请号：US12809242
申请日：2008-12-22
Applicant: Knut Johansen
Inventor： Knut Johansen
IPC: G01N21/55
CPC classification number: G01N21/553 , B82Y20/00 , G02B6/1226
Abstract: An apparatus with a radiation source 100 which has means for irradiation 610 of electromagnetic radiation with a plurality of wavelengths onto a sensor surface 210 which can support a surface plasmon, and said radiation is reflected onto at least one photosensitive detector 300, and create reflectance values, characterized by that said wavelengths at said detector are separated by wavelength, forming a wavelength ensemble, in such way that a continuous response signal can be calculated using at least three of said wavelength reflectance values, finding the wavelength closest to the resonance condition and use of adjacent wavelengths to calculate said continuous response signal 510 being a function of an effective refractive index at said sensor surface 210, where, if the resonance wavelength is the first or last of said wavelengths, at least two adjacent wavelengths closest to said closest wavelength to said resonance condition are used to calculate said continuous response signal. The present invention also relates to a method.
Abstract translation: 具有辐射源100的装置，其具有用于将具有多个波长的电磁辐射的辐射610放置在能够支撑表面等离子体的传感器表面210上的装置，并且所述辐射被反射到至少一个光敏检测器300上，并且产生反射率值 其特征在于，所述检测器处的所述波长被波长分开，形成波长整体，使得可以使用至少三个所述波长反射率值来计算连续响应信号，找到最接近共振条件的波长和使用 以计算所述连续响应信号510是所述传感器表面210处的有效折射率的函数，其中如果谐振波长是所述波长的第一个或最后一个，则至少两个相邻波长最接近所述最接近的波长 所述谐振条件用于计算所述连续响应信号。 本发明还涉及一种方法。
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公开(公告)号：US20090263827A1
公开(公告)日：2009-10-22
申请号：US12456037
申请日：2009-06-10
Applicant: Knut Johansen
Inventor： Knut Johansen
CPC classification number: G01N33/6893 , G01N2800/324
Abstract: A method to extract information from samples taken at different times from a mammalian. These samples are analyzed with respect to one or more analytes giving one or more responses, creating one or more response curves. From this/these response curves is/are changes in the responses calculated as slope, curvatures or mathematical functions. This is especially useful for early detection of acute myocardial infarction.
Abstract translation: 从不同时期从哺乳动物采集的样品中提取信息的方法。 分析这些样品相对于给出一个或多个反应的一种或多种分析物，产生一个或多个响应曲线。 从这个/这些响应曲线是作为斜率，曲率或数学函数计算的响应的变化。 这对急性心肌梗死的早期检测特别有用。
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Patent Agency Ranking
公开(公告)号：US5135576A
公开(公告)日：1992-08-04
申请号：US600016
申请日：1990-10-18
Applicant: Knut Johansen , Oyvind Larsen , Terje Nilsen
Inventor： Knut Johansen , Oyvind Larsen , Terje Nilsen
IPC: C04B14/30 , B32B20060101 , B32B13/04 , B32B18/00 , C04B14/04 , C04B14/32 , C04B28/02 , C04B28/06 , C04B32/00 , C04B32/02 , C04B35/00 , C04B35/71 , C04B37/00 , C04B41/50 , C04B41/65
CPC classification number: C04B28/02 , C04B28/06 , C04B35/71 , C04B2111/56 , C04B2201/52
Abstract: The present invention relates to combined structures of ceramic material and super concrete, which structures comprise an outer layer of ceramic material bonded to an internal structure of super concrete or an outer structure of super concrete bonded to an inner layer of ceramic material.The ceramic material is selected among any class of inorganic non-metallic products which are subjected to a temperature of 540.degree. C. and above during manufacture or use, while the super concrete comprises densely packed particles of inorganic materials embedded in a matrix based on an hydraulic cement and having a strength of at least 70 MPa.
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公开(公告)号：US20100103421A1
公开(公告)日：2010-04-29
申请号：US12447825
申请日：2007-10-29
Applicant: Knut Johansen , Mats Ränby
Inventor： Knut Johansen , Mats Ränby
CPC classification number: G01N21/553 , G01N21/03 , G01N2021/0307 , G01N2021/0346
Abstract: The invention relates to a sensor unit for a Surface Plasmon Resonance (SPR) unit, comprising a transparent sensor structure forming at least one wall of a cavity, the wall being defined by a concave inner surface and a convex outer surface The inner surface is provided with a layer of a conductive material capable of supporting a surface plasmon. In the cavity there is provided a flow structure in said cavity so as to form at least one compartment for sample between the flow structure and the inner wall of the cavity. Also, a method for the detection of events at a surface by utilizing surface plasmon resonance is provided. It comprises placing a sample with an analyte of interest in a sensor unit as claimed in claim 1, and measuring the reflectance from said sensor unit at a single or plurality of angle/angles.
Abstract translation: 本发明涉及一种用于表面等离子体共振（SPR）单元的传感器单元，其包括形成空腔的至少一个壁的透明传感器结构，该壁由凹内表面和凸形外表面限定。内表面设置 具有能够支撑表面等离子体激元的导电材料层。 在空腔中，在所述空腔中设置有流动结构，以便在流动结构和空腔的内壁之间形成用于样品的至少一个隔室。 另外，提供了利用表面等离子共振来检测表面的事件的方法。 其包括将具有感兴趣的分析物的样品放置在如权利要求1所述的传感器单元中，并且以单个或多个角度/角度测量来自所述传感器单元的反射率。
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公开(公告)号：US08462344B2
公开(公告)日：2013-06-11
申请号：US12809242
申请日：2008-12-22
Applicant: Knut Johansen
Inventor： Knut Johansen
IPC: G01N21/55
CPC classification number: G01N21/553 , B82Y20/00 , G02B6/1226
Abstract: An apparatus with a radiation source 100 which has means for irradiation 610 of electromagnetic radiation with a plurality of wavelengths onto a sensor surface 210 which can support a surface plasmon, and said radiation is reflected onto at least one photosensitive detector 300, and create reflectance values, characterized by that said wavelengths at said detector are separated by wavelength, forming a wavelength ensemble, in such way that a continuous response signal can be calculated using at least three of said wavelength reflectance values, finding the wavelength closest to the resonance condition and use of adjacent wavelengths to calculate said continuous response signal 510 being a function of an effective refractive index at said sensor surface 210, where, if the resonance wavelength is the first or last of said wavelengths, at least two adjacent wavelengths closest to said closest wavelength to said resonance condition are used to calculate said continuous response signal. The present invention also relates to a method.
Abstract translation: 具有辐射源100的装置，其具有用于将具有多个波长的电磁辐射的辐射610放置在能够支撑表面等离子体的传感器表面210上的装置，并且所述辐射被反射到至少一个光敏检测器300上，并且产生反射率值 其特征在于，所述检测器处的所述波长被波长分开，形成波长整体，使得可以使用至少三个所述波长反射率值来计算连续响应信号，找到最接近共振条件的波长和使用 以计算所述连续响应信号510是所述传感器表面210处的有效折射率的函数，其中如果谐振波长是所述波长的第一个或最后一个，则至少两个相邻波长最接近所述最接近的波长 所述谐振条件用于计算所述连续响应信号。 本发明还涉及一种方法。
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公开(公告)号：US08243277B2
公开(公告)日：2012-08-14
申请号：US13420185
申请日：2012-03-14
Applicant: Knut Johansen , Mats Rånby
Inventor： Knut Johansen , Mats Rånby
CPC classification number: G01N21/553 , G01N21/03 , G01N2021/0307 , G01N2021/0346
Abstract: A surface plasmon apparatus includes a light source, a sensor unit for Surface Plasmon Resonance (SPR) which includes a transparent sensor structure forming at least one wall of a cavity, the wall being defined by a concave inner surface and a convex outer surface, wherein the inner surface is provided with a layer of a conductive material capable of supporting a surface plasmon, a flow structure in the cavity so as to form at least one compartment for sample between the flow structure and the inner wall of the cavity, a detector for detecting reflected light from the sensor unit, and a processing unit.
Abstract translation: 表面等离子体激元装置包括光源，用于表面等离子体共振（SPR）的传感器单元，其包括形成空腔的至少一个壁的透明传感器结构，所述壁由凹内表面和凸形外表面限定，其中 内表面设置有能够支撑表面等离子体的导电材料层，空腔中的流动结构，以便在流动结构和腔的内壁之间形成用于样品的至少一个隔室，用于 检测来自传感器单元的反射光，以及处理单元。
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公开(公告)号：US20120170036A1
公开(公告)日：2012-07-05
申请号：US13420185
申请日：2012-03-14
Applicant: Knut JOHANSEN , Mats RÅNBY
Inventor： Knut JOHANSEN , Mats RÅNBY
CPC classification number: G01N21/553 , G01N21/03 , G01N2021/0307 , G01N2021/0346
Abstract: A surface plasmon apparatus includes a light source, a sensor unit for Surface Plasmon Resonance (SPR) which includes a transparent sensor structure forming at least one wall of a cavity, the wall being defined by a concave inner surface and a convex outer surface, wherein the inner surface is provided with a layer of a conductive material capable of supporting a surface plasmon, a flow structure in the cavity so as to form at least one compartment for sample between the flow structure and the inner wall of the cavity, a detector for detecting reflected light from the sensor unit, and a processing unit.
Abstract translation: 表面等离子体激元装置包括光源，用于表面等离子体共振（SPR）的传感器单元，其包括形成空腔的至少一个壁的透明传感器结构，所述壁由凹内表面和凸形外表面限定，其中 内表面设置有能够支撑表面等离子体的导电材料层，空腔中的流动结构，以便在流动结构和腔的内壁之间形成用于样品的至少一个隔室，用于 检测来自传感器单元的反射光，以及处理单元。
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