公开(公告)号：US06783966B1

公开(公告)日：2004-08-31

申请号：US09641701

申请日：2000-08-21

申请人： Yoshinao Kojima ,  Satoshi Fukumoto ,  Keiko Furukawa ,  Tetsuya Okajima ,  Koichi Furukawa

发明人： Yoshinao Kojima ,  Satoshi Fukumoto ,  Keiko Furukawa ,  Tetsuya Okajima ,  Koichi Furukawa

IPC分类号： C12N1554

CPC分类号： C12N9/1051 ,  C12P19/58

摘要： The object of the present invention is to provide &agr;1,4-galactosyltransferase to transfer a galactose residue to C4 position of galactose residue of lactosylceramide or galactosylceramide, and DNA coding for the enzyme. What is provided includes the following polypeptides (a) and (b), and DNAs encoding thereof: (a) a polypeptide consisting of an amino acid sequence represented by the amino acid Nos. 46-353 in SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a galactose residue from a galactose donor to C4 position of galactose residue of lactosylceramide or galactosylceramide which serves as an acceptor.

摘要翻译： 本发明的目的是提供α1,4-半乳糖基转移酶将半乳糖残基转移到乳糖基神经酰胺或半乳糖神经酰胺的半乳糖残基的C4位，以及编码该酶的DNA。提供的包括以下多肽（a）和（b ）和其编码的DNA：（a）由SEQ ID NO：2中的氨基酸编号46-353所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，并且具有从半乳糖供体转移半乳糖残基的酶活性 至作为受体的乳糖神经酰胺或半乳糖神经酰胺的半乳糖残基的C4位置。

公开(公告)号：US07080800B2

公开(公告)日：2006-07-25

申请号：US10298647

申请日：2002-11-19

申请人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

发明人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

IPC分类号： B65H75/48

CPC分类号： B60R22/44 ,  B60R2022/444 ,  B60R2022/4473

摘要： In controlling a seat belt retractor, at least one of signals selected from a state signal showing a movement of an occupant wearing a seat belt and an external signal obtained from detecting means installed in a vehicle during running thereof is received. Then, a rotational torque of a motor is selected to a predetermined reduction ratio corresponding to at least one of the state signal and the external signal from a plurality of torques. The motor is controlled to a predetermined torque, to thereby wind the webbing on the spool.

摘要翻译： 在控制座椅安全带卷收器时，接收从运行中安装在车辆中的检测装置获得的表示乘坐安全带的乘员的运动的状态信号和外部信号中选出的信号中的至少一种。 然后，根据多个转矩，将电动机的转矩选择为与至少一个状态信号和外部信号对应的预定减速比。 将电动机控制到预定的扭矩，从而将织带卷绕在卷轴上。

公开(公告)号：US06329893B1

公开(公告)日：2001-12-11

申请号：US09769730

申请日：2001-01-26

申请人： Koichi Furukawa ,  Yutaka Yamaguchi

发明人： Koichi Furukawa ,  Yutaka Yamaguchi

IPC分类号： H01H900

CPC分类号： B60R22/48 ,  B60R2022/4816

摘要： A buckle is provided with a non-contact buckle switch to find an engagement condition with a tongue. When a lock member of the buckle is disposed in a locking position, a magnetic field produced by a magnet and applied to an IC Hall element differs from a case where the lock member is disposed in a non-locking position. The difference of the magnetic field is caused by the magnetic lock member moved close to the magnet and the IC Hall element, whereby an electrical current outputted by the electromotive force of the IC Hall element is changed. Thus, it is possible to determine that the lock pin is set in the locking position. The buckle switch is improved in durability and can operate more reliably.

摘要翻译： 带扣设置有非接触式带扣开关，以找到舌头的接合状态。 当扣环的锁定构件设置在锁定位置时，由磁体产生并施加到IC霍尔元件的磁场与锁定构件设置在非锁定位置的情况不同。 磁场的差异是由磁性锁定构件靠近磁体和IC霍尔元件移动引起的，从而改变由IC霍尔元件的电动势输出的电流。 因此，可以确定锁定销被设置在锁定位置。 带扣开关的耐用性提高，可以更可靠地进行操作。

公开(公告)号：US6069988A

公开(公告)日：2000-05-30

申请号：US884068

申请日：1997-06-27

申请人： Kunio Kokura ,  Koichi Furukawa ,  Ikuo Ota ,  Kazunori Watanabe ,  Shigehito Yodo ,  Luksun Li

发明人： Kunio Kokura ,  Koichi Furukawa ,  Ikuo Ota ,  Kazunori Watanabe ,  Shigehito Yodo ,  Luksun Li

IPC分类号： G02B6/34 ,  G02B6/38

CPC分类号： G02B6/29317 ,  G02B6/021 ,  G02B6/02123 ,  G02B6/2558 ,  G02B6/3845

摘要： An optical fiber which comprises a coating layer disposed outside a bare optical fiber having a core and a cladding and a grating formed in the core of the exposed bare optical fiber by removing the coating layer and its manufacturing method. The optical fiber is provided with a re-coating layer disposed in the exposed bare optical fiber.

摘要翻译： 一种光纤，其包括设置在具有芯和包层的裸光纤外侧的涂层和通过去除涂层而形成在暴露的裸光纤的芯中的光栅及其制造方法。 光纤设置有设置在露出的裸光纤中的再涂层。

公开(公告)号：US5173292A

公开(公告)日：1992-12-22

申请号：US212312

申请日：1988-06-14

申请人： David S. Schrump ,  Koichi Furukawa ,  Hiroshi Yamaguchi ,  Kenneth O. Lloyd ,  Lloyd J. Old

发明人： David S. Schrump ,  Koichi Furukawa ,  Hiroshi Yamaguchi ,  Kenneth O. Lloyd ,  Lloyd J. Old

IPC分类号： C07K16/30

CPC分类号： C07K16/30

摘要： This invention provides a composition useful for diagnosing cancer which specifically recognizes a galactosyl-globoside. Preferably, the composition is a monoclonal antibody which specifically recognize the galactosyl-globoside antigen, gal-Gb4.Additionally, the present invention provides two hybridoma cell lines, designated J309 and D579, which produce monoclonal antibodies that specifically recognize gal-Gb4.The invention also provides a method of diagnosing a carcinoma which comprises contacting a sample from a human subject with a composition which specifically recognizes a galactosyl-globoside antigen and is labeled with a detectable moiety, under suitable conditions so as to form a detectable complex. The amount of formed complex is then quantified and correlated with values obtained from subjects devoid of carcinomas.Another aspect of the invention provides a method of treating carcinoma which comprises administering an effective amount of galactosyl-globoside or an analog thereof and a pharmaceutically carrier to stimulate the body production of antibodies.

摘要翻译： 本发明提供了可用于诊断特异性识别半乳糖基 - 球苷的癌症的组合物。 优选地，组合物是特异性识别半乳糖苷 - 球苷抗原gal-Gb4的单克隆抗体。 此外，本发明提供了两种称为J309和D579的杂交瘤细胞系，其产生特异性识别gal-Gb4的单克隆抗体。 本发明还提供了一种诊断癌症的方法，其包括使人受试者的样品与特异性识别半乳糖基 - 球蛋白抗原的组合物接触，并在适当的条件下用可检测的部分标记，以形成可检测的复合物。 然后将形成的复合物的量定量并与从没有癌的受试者获得的值相关联。 本发明的另一方面提供了一种治疗癌症的方法，其包括施用有效量的半乳糖基 - 球苷或其类似物和药物载体以刺激抗体的体内产生。

公开(公告)号：US4647239A

公开(公告)日：1987-03-03

申请号：US752856

申请日：1985-07-08

申请人： Tokio Maezawa ,  Koichi Furukawa

发明人： Tokio Maezawa ,  Koichi Furukawa

IPC分类号： B41J11/00 ,  B41J13/20 ,  B41J29/42 ,  B41J13/16

CPC分类号： B41J13/20 ,  B41J11/003 ,  B41J11/0095 ,  B41J29/42

摘要： A paper loading system for use in a printer has a platen and a paper bail mounted with two rollers. A carriage having a projection is provided to move parallelly to the platen. At the free end of the projection, a photodetector is provided to detect an edge of a loaded paper so as to memorize the opposite ends of the loaded paper. When the paper bail is in a pressing position at which rollers are holding the paper on a path of advance of the paper, no engagement is accomplished between the projection and the rollers. But when the paper bail is in a releasing position at which rollers are separated from the path to release the paper, the projection may come into contact with rollers to change the position of rollers. Using the memorized data, the movements of the carriage and the paper bail are controlled to locate the rollers at the opposite side rims of the loaded paper.

摘要翻译： 用于打印机的纸张装载系统具有安装有两个辊子的压板和纸张吊环。 具有突出部的滑架被设置成平行于台板移动。 在投影的自由端处，设置有光电检测器以检测装入的纸张的边缘，以便记住装入的纸张的相对端部。 当纸张吊环处于按压位置时，辊将纸张保持在纸张前进的路径上，在突起和辊之间不会实现接合。 但是当纸张吊环处于释放位置时，辊子与路径分离以释放纸张，突起可以与辊接触以改变辊子的位置。 使用存储的数据，控制托架和纸吊环的移动以将辊定位在装载纸张的相对侧边缘处。

公开(公告)号：US4601595A

公开(公告)日：1986-07-22

申请号：US710272

申请日：1985-03-11

申请人： Masahiko Aiba ,  Koichi Furukawa

发明人： Masahiko Aiba ,  Koichi Furukawa

IPC分类号： B41J13/00 ,  B41J13/02 ,  B41J13/036 ,  B41J13/20 ,  B41J13/16

CPC分类号： B41J13/20 ,  B41J13/02 ,  B41J13/036

摘要： A paper sheet setting mechanism in a printer such as an ink jet system printer includes a memory device which stores a desired left setting position at which a left paper pressing roller should be positioned, and a desired right setting position at which a right paper pressing roller should be positioned. C-shaped guide plates are secured to the paper pressing rollers. Each of the C-shaped guide plates includes a roof member which is made contact with a pritrusion secured to a printer head when a shaft of the paper pressing rollers is held at a first stable position. When the printer head is driven to shift while the shaft is held at the first stable position, the paper pressing rollers are shifted on the shaft and controlled to be positioned at the desired left and right setting positions, respectively.

摘要翻译： 在诸如喷墨系统打印机的打印机中的纸张设置机构包括：存储装置，该存储装置存储要放置左纸张加压辊的期望的左设定位置，以及期望的右设定位置，在该期间右纸张加压辊 应该定位 C形导板固定在纸压辊上。 每个C形引导板包括顶盖构件，当屋顶构件与压纸辊的轴保持在第一稳定位置时，该屋顶构件与固定到打印机头上的突起接触。 当轴被保持在第一稳定位置时打印头被驱动移动时，纸张按压辊在轴上移动并分别被控制在所需的左右设置位置。

公开(公告)号：US06827308B2

公开(公告)日：2004-12-07

申请号：US10177142

申请日：2002-06-24

申请人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

发明人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

IPC分类号： B65H7548

CPC分类号： B60R22/44 ,  B60R2022/444 ,  B60R2022/4473

摘要： In controlling a seat belt retractor, at least one of signals selected from a state signal showing a movement of an occupant wearing a seat belt and an external signal obtained from detecting means installed in a vehicle during running thereof is received. Then, a rotation of a spool for a webbing is controlled by switching a rotational torque of a motor to a predetermined reduction ratio corresponding to at least one of the state signal and the external signal, or a driving state of the motor is controlled to a predetermined torque, to thereby wind the webbing on the spool. After fastening the seat belt, the seat belt is automatically wound, and after a predetermined time from completion of winding of the webbing, it is determined whether the winding of the webbing is further needed, and if necessary, the webbing is wound again.

摘要翻译： 在控制座椅安全带卷收器时，接收从运行中安装在车辆中的检测装置获得的表示乘坐安全带的乘员的运动的状态信号和外部信号中选出的信号中的至少一种。 然后，通过将电动机的旋转转矩切换到对应于状态信号和外部信号中的至少一个的预定减速比来控制用于织带的线轴的旋转，或者将电动机的驱动状态控制为 预定扭矩，从而将织带卷绕在卷轴上。 在紧固安全带之后，安全带自动卷绕，并且在织带卷绕结束之后的预定时间之后，确定进一步需要卷带是否需要，并且如果需要，再次卷绕织带。

公开(公告)号：US06772973B2

公开(公告)日：2004-08-10

申请号：US10317184

申请日：2002-12-12

申请人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

发明人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

IPC分类号： B60R2246

CPC分类号： B60R22/44 ,  B60R2022/444 ,  B60R2022/4473

摘要： A seat belt retractor includes a base frame, a spool having a spool shaft journalled to the base frame, a webbing wound around the spool, a return spring connected to the spool for winding the webbing by a return force thereof, a motor connected to the spool for winding the spool, and a speed-reduction mechanism interposed between the motor and the spool. The speed-reduction mechanism winds the webbing at a low speed for fitting the webbing to an occupant, and includes a contrate gear with a predetermined reduction gear ratio. Thus, the webbing is wound by operation of the motor via the contrate gear.

摘要翻译： 安全带卷收器包括基座框架，具有轴颈安​​装在基架上的卷轴，卷绕在卷轴上的织带，连接到卷轴的复位弹簧，用于通过其回复力来缠绕织带，马达连接到 用于卷绕卷轴的卷轴，以及插入在马达和卷轴之间的减速机构。 减速机构以较低的速度卷绕织带，以将织带装配到乘员，并且包括具有预定的减速比的止挡齿轮。 因此，织带通过马达的操作通过调节齿轮而被缠绕。

公开(公告)号：US06427935B1

公开(公告)日：2002-08-06

申请号：US09484450

申请日：2000-01-18

申请人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

发明人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

IPC分类号： B60R2234

CPC分类号： B60R22/44 ,  B60R2022/444 ,  B60R2022/4473

摘要： A seat belt retractor includes a base frame, a spool journalled to the base frame, a webbing wound around the spool, and a motor for rotating the spool. A speed-reduction mechanism is interposed between the motor and the spool. The speed-reduction mechanism includes at least one transmission train with a predetermined gear ratio, a common transmission element connected to the transmission train, and a resistant torque device connected to the transmission train. The common transmission element transmits rotation of the motor to the spool when the torque of the rotation is smaller than the preset value. Winding of the webbing is made based on the wearing condition of the webbing and the running condition of the vehicle.

摘要翻译： 一种座椅安全带卷收器，包括基座框架，安装在基座框架上的卷轴，缠绕在卷轴上的织带以及用于旋转卷轴的马达。 减速机构夹在电机和阀芯之间。 减速机构包括至少一个具有预定齿轮比的传动系，连接到传动系的公共传动元件和连接到传动系的阻力转矩装置。 当旋转的转矩小于预设值时，公共传动元件将电机的旋转传递到线轴。 基于织带的磨损状况和车辆的行驶状态进行织带的卷绕。