公开(公告)号：US20250101023A1

公开(公告)日：2025-03-27

申请号：US18730491

申请日：2023-01-19

Applicant: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gu KONG ,  Ratnakar Reddy KUCHUKULLA ,  Su Min KIM ,  So Jeong MOON ,  Woo Young HUR ,  In Jeong HWANG

IPC: C07D473/34 ,  A61K31/52 ,  A61K31/5377 ,  A61P35/00 ,  C07D473/16 ,  C07D473/40

Abstract: The present invention relates to a heteroaryl derivative, a stereoisomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The heteroaryl derivative of the present invention exhibits high inhibitory activity against overexpressed HER2, and thus, a pharmaceutical composition containing the same as an active ingredient can be usefully used for preventing or treating HER-2 positive cancer.

公开(公告)号：US12251914B2

公开(公告)日：2025-03-18

申请号：US18467610

申请日：2023-09-14

Applicant: Korea Institute of Science and Technology

Inventor： Seungjun Chung ,  Jun Chan Choi ,  Hoon Yeub Jeong ,  Phillip Lee ,  Jeong Gon Son ,  Heesuk Kim

IPC: B32B3/12 ,  B32B7/022 ,  B32B37/14

Abstract: Provided is a method of manufacturing a stretchable substrate having improved thickness deformation uniformity through control of a spatial crosslinking degree according to various embodiments of the present disclosure to implement the above object. The method includes forming a substrate part of an elastic material, forming an auxetic including a plurality of unit structures on the substrate part, and forming a fixing part on the substrate part on which the auxetic is formed, wherein the fixing part has a different vertical crosslinking density at each position.

公开(公告)号：US12251235B2

公开(公告)日：2025-03-18

申请号：US17507811

申请日：2021-10-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunjung Yi ,  Seongjin Park ,  Wonseop Hwang

IPC: A61B5/00 ,  A61B10/00 ,  A61F13/15 ,  A61F13/53

Abstract: A perspiration mapping patch according to the present disclosure is attached to skin of a user to absorb sweat, and includes: a sweat absorbing layer in which a plurality of opening units is arranged; a first support layer which is stacked on a first surface of the sweat absorbing layer and includes an opening opened to correspond to each of the plurality of opening units; and a second support layer stacked on a second surface facing an opposite side of the first surface of the sweat absorbing layer.

公开(公告)号：US20250084516A1

公开(公告)日：2025-03-13

申请号：US18958505

申请日：2024-11-25

Applicant: Hyundai Steel Company ,  Korea University Research and Business Foundation ,  Korea Institute of Science and Technology

Inventor： Jun Ho Chung ,  Tae Hyung Kim

IPC: C22C38/32 ,  C21D8/02 ,  C21D8/06 ,  C22C38/00 ,  C22C38/02 ,  C22C38/04 ,  C22C38/20 ,  C22C38/24 ,  C22C38/26 ,  C22C38/28 ,  C22C38/40

Abstract: Provided is a steel reinforcement including an amount of 0.07 to 0.43 wt % of carbon (C), an amount of 0.5 to 2.0 wt % of manganese (Mn), an amount of 0.05 to 0.5 wt % of silicon (Si), an amount greater than 0 and less than or equal to 0.5 wt % of chromium (Cr), an amount greater than 0 and less than or equal to 4.5 wt % of copper (Cu), an amount greater than 0 and less than or equal to 0.003 wt % of boron (B), an amount greater than 0 and less than or equal to 0.25 wt % of vanadium (V), an amount greater than 0 and less than or equal to 0.012 wt % of nitrogen (N), an amount greater than 0 and less than or equal to 0.03 wt % of phosphorus (P), an amount greater than 0 and less than or equal to 0.03 wt % of sulfur(S), an amount of 0.01 to 0.5 wt % of the sum of one or more of nickel (Ni), niobium (Nb) and titanium (Ti), the balance of iron (Fe), and other inevitable impurities. A final microstructure includes ferrite, bainite, pearlite, retained austenite, and precipitates comprising copper.

公开(公告)号：US20250051608A1

公开(公告)日：2025-02-13

申请号：US18627147

申请日：2024-04-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Myoung-Woon MOON ,  Seong Jin KIM ,  Young A LEE ,  CHAN YOUNG OH ,  Sang-Jin PARK

IPC: C09D179/04

Abstract: Provided is a polydopamine composite material according to the concept of the present invention, wherein the polydopamine composite material includes a substrate with first nano-protrusions formed on a surface thereof, and a polydopamine layer on the surface of the substrate. The polydopamine layer includes second nano-protrusions protruding in a direction perpendicular to the surface of the substrate.

公开(公告)号：US20250033471A1

公开(公告)日：2025-01-30

申请号：US18514493

申请日：2023-11-20

Applicant: HYUNDAI MOTOR COMPANY ,  KIA CORPORATION ,  Korea Institute of Science and Technology

Inventor： Dong Gu Kim ,  Jang Hyeon Lee ,  Dae Sung Kwon ,  Hyun Soo Kim ,  Il Seon Yoo ,  Byung Chul Lee ,  Seong Hun Cho ,  Seung Hyub Baek ,  Min Seok Kim ,  Soo Young Jung

IPC: B60K35/00 ,  G06F3/01 ,  G06F3/043 ,  G06F3/0482 ,  G06V20/56 ,  G06V40/10 ,  G06V40/20

Abstract: A non-contact interface device for a vehicle and a method for controlling the same, may display an operation system menu for a driver and passengers to operate various kinds of devices of the vehicle as a hologram, enable a user to operate the displayed operation system menu in a non-contact manner by use of the user's finger or the like, and provide the user with a tactile feedback for a non-contact operation, so that the user can recognize whether to have operated the menu.

公开(公告)号：US12211899B2

公开(公告)日：2025-01-28

申请号：US17583206

申请日：2022-01-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyung-jun Kim ,  Seung Hwan Kim

IPC: H01L21/00 ,  H01L21/02 ,  H01L29/10

Abstract: Embodiments relate to a semiconductor device, which includes: a substrate made of a first material; an insulating layer formed on an upper surface of the substrate; a trench formed at the insulating layer to penetrate the insulating layer toward the substrate; and a seed layer disposed in the trench. The seed layer is made of a second material, the second material lattice-mismatches with respect to the first material, the seed layer includes a threading dislocation extending at least partially in a first direction non-parallel to the upper surface of the substrate and parallel to a direction of a (111) plane and a threading dislocation extending at least partially in a second direction, and the extension of the threading dislocation is terminated at a sidewall of the trench.

公开(公告)号：US20250026102A1

公开(公告)日：2025-01-23

申请号：US18467610

申请日：2023-09-14

Applicant: Korea Institute of Science and Technology

Inventor： Seungjun CHUNG ,  Jun Chan CHOI ,  Hoon Yeub JEONG ,  Phillip LEE ,  Jeong Gon SON ,  Heesuk KIM

IPC: B32B3/12 ,  B32B7/022 ,  B32B37/14

Abstract: Provided is a method of manufacturing a stretchable substrate having improved thickness deformation uniformity through control of a spatial crosslinking degree according to various embodiments of the present disclosure to implement the above object. The method includes forming a substrate part of an elastic material, forming an auxetic including a plurality of unit structures on the substrate part, and forming a fixing part on the substrate part on which the auxetic is formed, wherein the fixing part has a different vertical crosslinking density at each position.

公开(公告)号：US20250026101A1

公开(公告)日：2025-01-23

申请号：US18467594

申请日：2023-09-14

Applicant: Korea Institute of Science and Technology

Inventor： Seungjun CHUNG ,  Jun Chan CHOI ,  Hoon Yeub JEONG ,  Jeong Gon SON ,  Heesuk KIM ,  Phillip LEE

IPC: B32B3/12 ,  B32B7/022 ,  B32B37/14

Abstract: Provided is a method of manufacturing a stretchable substrate having improved stretching deformation uniformity through control of a spatial crosslinking degree according to various embodiments of the present disclosure to implement the above object. The method includes forming a substrate part of an elastic material, forming an auxetic including a plurality of unit structures on the substrate part, and forming a fixing part on the substrate part on which the auxetic is formed, wherein the fixing part has a different crosslinking density in each region.

公开(公告)号：US20250019705A1

公开(公告)日：2025-01-16

申请号：US18745018

申请日：2024-06-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  DANA-FARBER CANCER INSTITUTE, INC.

Inventor： Ju Hee RYU ,  Ick Chan KWON ,  Youngji KO ,  Thomas M. ROBERTS ,  Jean J. ZHAO ,  Liya DING

IPC: C12N15/113 ,  A61K45/06 ,  A61K47/64 ,  A61K47/65 ,  A61P35/00

Abstract: Provided is BRCA-specific siRNA for enhancing the sensitivity of cancer cells to PARP inhibitors. According to the present disclosure, the siRNA can induce cancer cell death together with the PARP inhibitors in patients with wild-type BRCA genes with a low therapeutic effect of the PARP inhibitors, and the fusion protein-siRNA complex for siRNA delivery is up-taken into cells via CD47, and thus more specifically delivered to cancer cells while up-taken with high efficiency, thereby maximizing a desired cell death effect.