公开(公告)号：US09474770B2

公开(公告)日：2016-10-25

申请号：US14237407

申请日：2012-08-10

申请人： Kosaku Kinoshita ,  Katsuhisa Tanjoh ,  Akihiro Noda ,  Atsushi Sakurai ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

发明人： Kosaku Kinoshita ,  Katsuhisa Tanjoh ,  Akihiro Noda ,  Atsushi Sakurai ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

IPC分类号： A61K33/26 ,  A61K31/197 ,  A61K31/28 ,  A61K31/295 ,  A61K45/06

CPC分类号： A61K33/26 ,  A61K31/197 ,  A61K31/28 ,  A61K31/295 ,  A61K45/06

摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.

摘要翻译： 本发明提供了可用于预防和治疗败血症的败血症治疗药物。 制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。 除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的​​酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

公开(公告)号：US20140186464A1

公开(公告)日：2014-07-03

申请号：US14237407

申请日：2012-08-10

申请人： Kosaku Kinoshita ,  Katsuhisa Tanjoh ,  Akihiro Noda ,  Atsushi Sakurai ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

发明人： Kosaku Kinoshita ,  Katsuhisa Tanjoh ,  Akihiro Noda ,  Atsushi Sakurai ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

IPC分类号： A61K33/26 ,  A61K45/06 ,  A61K31/197

CPC分类号： A61K33/26 ,  A61K31/197 ,  A61K31/28 ,  A61K31/295 ,  A61K45/06

摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.

摘要翻译： 本发明提供了可用于预防和治疗败血症的败血症治疗药物。 制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。 除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的​​酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。