ENHANCER OF SURVIVAL OF TRANSPLANTED ORGAN
    3.
    发明申请
    ENHANCER OF SURVIVAL OF TRANSPLANTED ORGAN 有权
    运输机构存货增值

    公开(公告)号:US20140249217A1

    公开(公告)日:2014-09-04

    申请号:US14350488

    申请日:2012-09-12

    IPC分类号: A61K31/197 A61K31/295

    摘要: The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.

    摘要翻译: 本发明提供了一种用于促进移植物存活的药剂,其可以抑制不使用现有的免疫抑制剂的排斥反应,能够保持从供体排出的器官的新鲜度的器官保存溶液等。 制备促进移植物存活的药物或器官保存溶液,其包含5-氨基乙酰丙酸(ALA)或其衍生物,或ALA或其衍生物和铁化合物的盐作为活性成分。 ALA的优选实例可以包括ALA和各种酯,例如ALA的甲酯,乙酯,丙酯,丁酯和戊酯,以及它们的盐酸盐,磷酸盐和硫酸盐。 铁化合物的优选实例可包括柠檬酸亚铁钠。

    Cancer heat therapy-enhancing agent
    5.
    发明授权
    Cancer heat therapy-enhancing agent 有权
    癌症热疗增强剂

    公开(公告)号:US09012502B2

    公开(公告)日:2015-04-21

    申请号:US13820303

    申请日:2011-09-12

    CPC分类号: C07C229/22 A61K31/197

    摘要: Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3  (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

    摘要翻译: 提供了不与光动力疗法结合的癌症热疗的增强剂。 通过使用作为癌症热疗的增强剂,可以通过使用由式(1)表示的5-氨基乙酰丙酸获得癌症治疗:R2R1NCH2COCH2CH2COR3(1)[其中R1和R2各自独立地表示氢原子,烷基 ,酰基,烷氧基羰基,芳基或芳烷基; R3表示羟基,烷氧基,酰氧基,烷氧基羰基氧基,芳氧基,芳烷氧基或氨基)或其盐。

    CANCER HEAT THERAPY-ENHANCING AGENT
    6.
    发明申请
    CANCER HEAT THERAPY-ENHANCING AGENT 有权
    癌症治疗增强剂

    公开(公告)号:US20130158293A1

    公开(公告)日:2013-06-20

    申请号:US13820303

    申请日:2011-09-12

    IPC分类号: C07C229/22

    CPC分类号: C07C229/22 A61K31/197

    摘要: Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3   (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

    摘要翻译: 提供了不与光动力疗法结合的癌症热疗的增强剂。 通过使用作为癌症热疗的增强剂,可以通过使用由式(1)表示的5-氨基乙酰丙酸获得癌症治疗:R2R1NCH2COCH2CH2COR3(1)[其中R1和R2各自独立地表示氢原子,烷基 ,酰基,烷氧基羰基,芳基或芳烷基; R3表示羟基,烷氧基,酰氧基,烷氧基羰基氧基,芳氧基,芳烷氧基或氨基)或其盐。