公开(公告)号：US20130209520A1

公开(公告)日：2013-08-15

申请号：US13697706

申请日：2011-05-20

Applicant: Kosta Ladavac ,  Rodrigo Guerra ,  David Kaz ,  Vinothan N. Manoharan ,  Jens B. Rieger ,  Roland S. Koltzenburg ,  David A. Weitz

Inventor： Kosta Ladavac ,  Rodrigo Guerra ,  David Kaz ,  Vinothan N. Manoharan ,  Jens B. Rieger ,  Roland S. Koltzenburg ,  David A. Weitz

IPC: A61K9/12

CPC classification number: A61K9/122 ,  A61K9/143 ,  A61K9/146 ,  A61K9/5115

Abstract: The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.

Abstract translation: 本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。 泡沫或颗粒可以包含药学上可接受的聚合物载体。 在一些情况下，泡沫可以包括胶体颗粒。 本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。 在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。 这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从 泡沫。 在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。 在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。 泡沫在某些情况下可能是微孔的。 泡沫也可以使用超临界流体，例如超临界CO 2来产生。 例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。 然后可以降低压力，从而使发泡剂膨胀并引起泡沫形成。 泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

公开(公告)号：US20090107667A1

公开(公告)日：2009-04-30

申请号：US11925219

申请日：2007-10-26

Applicant: Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

Inventor： Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

IPC: E21B47/00

CPC classification number: G01N31/224 ,  C09K8/52 ,  C09K2208/20 ,  E21B49/08 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7786

Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

Abstract translation: 描述了用于检测井下地层流体中的硫化氢的方法和相关装置和混合物。 检测混合物与井下的地层流体结合。 该检测混合物包括与形成金属硫化物的硫化氢反应的金属离子，以及带电的纳米粒子尺寸以抑制金属硫化物的显着聚集，从而能够对井下金属硫化物进行光谱检测。 然后用光谱询问合并的混合物和地层流体，以便检测金属硫化物的存在，从而指示地层流体中存在硫化氢。 混合物还包括螯合配体，用于在井下条件下维持混合物的耐热性。

公开(公告)号：US07473890B2

公开(公告)日：2009-01-06

申请号：US11285224

申请日：2005-11-22

Applicant: David G. Grier ,  Marco Polin ,  Sang-Hyuk Lee ,  Yael Roichman ,  Kosta Ladavac

Inventor： David G. Grier ,  Marco Polin ,  Sang-Hyuk Lee ,  Yael Roichman ,  Kosta Ladavac

IPC: H01H3/02

CPC classification number: G03H1/08 ,  G03H1/22 ,  G03H1/2249 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T428/12486

Abstract: Holographic optical traps using the forces exerted by computer-generated holograms to trap, move and otherwise transform mesoscopically textured materials. The efficacy of the present invention is based upon the quality and nature of the diffractive optical element used to create the traps and dynamically use them. Further a landscape of potential energy sites can be created and used to manipulate, sort and process objects.

Abstract translation: 全息光学陷阱使用由计算机生成的全息图施加的力来捕获，移动和以其他方式转换中观纹理材料。 本发明的功效基于用于产生捕获物并用于动态使用它们的衍射光学元件的质量和性质。 此外，可以创建潜在能量场地的景观，并用于操纵，排序和处理对象。

公开(公告)号：US20110111507A1

公开(公告)日：2011-05-12

申请号：US13009405

申请日：2011-01-19

Applicant: Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

Inventor： Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

IPC: G01N33/24

CPC classification number: G01N31/224 ,  C09K8/52 ,  C09K2208/20 ,  E21B49/08 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7786

Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

公开(公告)号：US20110104809A1

公开(公告)日：2011-05-05

申请号：US13009424

申请日：2011-01-19

Applicant: Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

Inventor： Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E.G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

IPC: G01N33/24

CPC classification number: G01N31/224 ,  C09K8/52 ,  C09K2208/20 ,  E21B49/08 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7786

Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

Abstract translation: 描述了用于检测井下地层流体中的硫化氢的方法和相关装置和混合物。 检测混合物与井下的地层流体结合。 该检测混合物包括与形成金属硫化物的硫化氢反应的金属离子，以及带电的纳米粒子尺寸以抑制金属硫化物的显着聚集，从而能够对井下金属硫化物进行光谱检测。 然后用光谱询问合并的混合物和地层流体，以便检测金属硫化物的存在，从而指示地层流体中存在硫化氢。 混合物还包括螯合配体，用于在井下条件下维持混合物的耐热性。

公开(公告)号：US20090101807A1

公开(公告)日：2009-04-23

申请号：US12343193

申请日：2008-12-23

Applicant: David G. Grier ,  Marco Polin ,  Sang-Hyuk Lee ,  Yael Roichman ,  Kosta Ladavac

Inventor： David G. Grier ,  Marco Polin ,  Sang-Hyuk Lee ,  Yael Roichman ,  Kosta Ladavac

IPC: H05H3/00 ,  G02B5/32 ,  G03H1/08

CPC classification number: G03H1/08 ,  G03H1/22 ,  G03H1/2249 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T428/12486

Abstract: Holographic optical traps using the forces exerted by computer-generated holograms to trap, move and otherwise transform mesoscopically textured materials. The efficacy of the present invention is based upon the quality and nature of the diffractive optical element used to create the traps and dynamically use them. Further a landscape of potential energy sites can be created and used to manipulate, sort and process objects.

Abstract translation: 全息光学陷阱使用由计算机生成的全息图施加的力来捕获，移动和以其他方式转换中观纹理材料。 本发明的功效基于用于产生捕获物并用于动态使用它们的衍射光学元件的质量和性质。 此外，可以创建潜在能量场地的景观，并用于操纵，排序和处理对象。

公开(公告)号：US20080316575A1

公开(公告)日：2008-12-25

申请号：US12155503

申请日：2008-06-05

Applicant: Jennifer E. Curtis ,  Brian A. Koss ,  David G. Grier ,  Kosta Ladavac ,  Karen Kasza

Inventor： Jennifer E. Curtis ,  Brian A. Koss ,  David G. Grier ,  Kosta Ladavac ,  Karen Kasza

IPC: G02F1/01 ,  G02B5/18 ,  G01B9/00

CPC classification number: G02B21/32

Abstract: A method and system for correcting aberrations in a beam of light including correcting for effects from an undiffracted portion of an input beam. The method and system includes (1) a component for providing a beam of light; (2) a component for applying a diffraction grating pattern to the beam of light to establish an optical gradient to form an optical trap; (3) component for measuring aberration in the beam of light having the applied diffraction grating pattern; (4) component for calculating a phase-shifting diffraction grating encoding the aberration; and (5) component for projecting the phase-shifting diffraction grating in conjunction with the diffraction grating pattern characteristic of the optical trap. The method and system also includes (1) providing an input beam of light; (2) applying a diffractive grating pattern to the input beam of light to establish a diffracted portion, apart from an undiffracted portion, to form at least one optical trap; (3) operating on both the diffracted portion and the undiffracted portion to bring the light to focus out of the focal plane; and (4) operating on the diffracted portion of the input beam of light (the optical trap) to modify focus of the diffracted portion relative to the undiffracted portion to bring the diffracted portion into focus in the focal plane.

Abstract translation: 一种用于校正光束中的像差的方法和系统，包括校正来自输入光束的未衍射部分的效果。 该方法和系统包括（1）用于提供光束的部件; （2）用于将衍射光栅图案应用于光束以建立光学梯度以形成光阱的部件; （3）用于测量具有施加的衍射光栅图案的光束中的像差的分量; （4）分量，用于计算编码像差的相移衍射光栅; 以及（5）用于将相移衍射光栅与光阱的衍射光栅图案特性相结合的部件。 该方法和系统还包括（1）提供输入光束; （2）将衍射光栅图案施加到所述输入光束以建立远离未衍射部分的衍射部分，以形成至少一个光阱; （3）在衍射部分和未衍射部分上操作以使光聚焦在焦平面之外; 和（4）在输入光束（光阱）的衍射部分上操作，以改变衍射部分相对于未衍射部分的焦点，以使衍射部分在焦平面中聚焦。

公开(公告)号：US07959864B2

公开(公告)日：2011-06-14

申请号：US11925219

申请日：2007-10-26

Applicant: Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E. G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

Inventor： Li Jiang ,  Oliver C. Mullins ,  Gale H. Gustavson ,  Christopher Harrison ,  Bhavani Raghuraman ,  Ronald E. G. Van Hal ,  Jimmy Lawrence ,  Kosta Ladavac ,  A. Ballard Andrews ,  Timothy Gareth John Jones ,  Rogerio Tadeu Ramos

IPC: G01N33/24

CPC classification number: G01N31/224 ,  C09K8/52 ,  C09K2208/20 ,  E21B49/08 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7786

Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

公开(公告)号：US20100147456A1

公开(公告)日：2010-06-17

申请号：US12705099

申请日：2010-02-12

Applicant: David G. GRIER ,  Kosta Ladavac ,  Joy M. Barker

Inventor： David G. GRIER ,  Kosta Ladavac ,  Joy M. Barker

IPC: B32B38/18

CPC classification number: C09J5/00 ,  G03H2001/0077 ,  Y10S977/882

Abstract: A system and method for bonding and unbonding of small objects using small adhesive particles. The system and method includes the use of a plurality of optical tweezers to manipulate objects to be bonded and adhesive particles suspended in a fluid. The objects to be bonded (or unbonded) and the adhesive particles are positioned by lower power optical tweezers and then an intense bonding optical tweezer is activated to cause the adhesive to join the objects together (or used to unbond objects).

Abstract translation: 一种使用小粘合剂颗粒粘合和粘合小物体的系统和方法。 该系统和方法包括使用多个光学镊子来操纵待粘合的物体和悬浮在流体中的粘合剂颗粒。 待粘合（或未粘合）的物体和粘合剂颗粒通过较低功率的光学镊子定位，然后激活强力粘合光学镊子以使粘合剂将物体连接在一起（或用于将物体接合）。

公开(公告)号：US20060291019A1

公开(公告)日：2006-12-28

申请号：US11473398

申请日：2006-06-23

Applicant: David Grier ,  Kosta Ladavac ,  Joy Barker

Inventor： David Grier ,  Kosta Ladavac ,  Joy Barker

IPC: G03H1/00

CPC classification number: C09J5/00 ,  G03H2001/0077 ,  Y10S977/882

Abstract: A system and method for bonding and unbonding of small objects using small adhesive particles. The system and method includes the use of a plurality of optical tweezers to manipulate objects to be bonded and adhesive particles suspended in a fluid. The objects to be bonded (or unbonded) and the adhesive particles are positioned by lower power optical tweezers and then an intense bonding optical tweezer is activated to cause the adhesive to join the objects together (or used to unbond objects).

Abstract translation: 一种使用小粘合剂颗粒粘合和粘合小物体的系统和方法。 该系统和方法包括使用多个光学镊子来操纵待粘合的物体和悬浮在流体中的粘合剂颗粒。 待粘合（或未粘合）的物体和粘合剂颗粒由较低功率的光学镊子定位，然后激活强力粘合光学镊子以使粘合剂将物体连接在一起（或用于取消粘合物体）。