公开(公告)号：US08507683B2

公开(公告)日：2013-08-13

申请号：US13310863

申请日：2011-12-05

Applicant: Kap-Sun Yeung ,  John F. Kadow ,  Rajesh Onkardas Bora ,  Kumaravel Selvakumar

Inventor： Kap-Sun Yeung ,  John F. Kadow ,  Rajesh Onkardas Bora ,  Kumaravel Selvakumar

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D405/14 ,  C07D407/12

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US20060122398A1

公开(公告)日：2006-06-08

申请号：US10523894

申请日：2003-08-07

Applicant: Ralf Karch ,  Oliver Briel ,  Bernd Kayser ,  Matthias Beller ,  Kumaravel Selvakumar ,  Anja Frisch ,  Alexander Zapf

Inventor： Ralf Karch ,  Oliver Briel ,  Bernd Kayser ,  Matthias Beller ,  Kumaravel Selvakumar ,  Anja Frisch ,  Alexander Zapf

IPC: C07F15/00 ,  C07C319/02 ,  C07F7/20

CPC classification number: B01J31/2291 ,  B01J31/2265 ,  B01J31/2273 ,  B01J31/2295 ,  B01J2231/20 ,  B01J2231/30 ,  B01J2231/4205 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07F15/006 ,  C07F15/0086 ,  C07F15/04

Abstract: The invention relates to novel monocarbene complexes of nickel, palladium or platinum with electron-deficient olefin ligands, to their preparation and to their use in the homogeneous catalysis of organic reactions.

Abstract translation: 本发明涉及镍，钯或铂与电子缺乏烯烃配体的新颖单烯烃络合物，其制备及其在均相催化有机反应中的应用。

公开(公告)号：US20180333395A1

公开(公告)日：2018-11-22

申请号：US16038739

申请日：2018-07-18

Applicant: Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  C07D249/06 ,  C07D401/14 ,  C07D401/04 ,  A61K31/27 ,  A61K31/454

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US07268233B2

公开(公告)日：2007-09-11

申请号：US10523894

申请日：2003-08-07

Applicant: Ralf Karch ,  Oliver Briel ,  Bernd Kayser ,  Matthias Beller ,  Kumaravel Selvakumar ,  Anja Frisch ,  Alexander Zapf

Inventor： Ralf Karch ,  Oliver Briel ,  Bernd Kayser ,  Matthias Beller ,  Kumaravel Selvakumar ,  Anja Frisch ,  Alexander Zapf

IPC: C07F15/00 ,  B01J31/00

CPC classification number: B01J31/2291 ,  B01J31/2265 ,  B01J31/2273 ,  B01J31/2295 ,  B01J2231/20 ,  B01J2231/30 ,  B01J2231/4205 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07F15/006 ,  C07F15/0086 ,  C07F15/04

Abstract: The invention relates to novel monocarbene complexes of nickel, palladium or platinum with electron-deficient olefin ligands, to their preparation and to their use in the homogeneous catalysis of organic reactions.

Abstract translation: 本发明涉及镍，钯或铂与电子缺乏烯烃配体的新颖单烯烃络合物，其制备及其在均相催化有机反应中的应用。

公开(公告)号：US20120309770A1

公开(公告)日：2012-12-06

申请号：US13310863

申请日：2011-12-05

Applicant: Kap-Sun Yeung ,  John F. Kadow ,  Rajesh Onkardas Bora ,  Kumaravel Selvakumar

Inventor： Kap-Sun Yeung ,  John F. Kadow ,  Rajesh Onkardas Bora ,  Kumaravel Selvakumar

IPC: A61K31/343 ,  A61P31/14 ,  A61K31/443 ,  A61K31/506 ,  C07D307/84 ,  C07D405/14

CPC classification number: C07D405/14 ,  C07D407/12

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。