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    Optically Active Alpha-Hydroxyphosphonic Acid, Its Derivatives and Production Method thereof, Optically Active Aluminum (Salalen) Complex and Production Method Thereof, and Production Method of Salalen Ligand
    2.
    发明申请
    Optically Active Alpha-Hydroxyphosphonic Acid, Its Derivatives and Production Method thereof, Optically Active Aluminum (Salalen) Complex and Production Method Thereof, and Production Method of Salalen Ligand 审中-公开
    光活性α-羟基膦酸及其衍生物及其制备方法，光活性铝（Salalen）复合物及其制备方法及Salalen配体的制备方法

    公开(公告)号：US20090099381A1

    公开(公告)日：2009-04-16

    申请号：US11918257

    申请日：2006-03-20

    申请人： Tsutomu Katsuki ,  Bunnai Saito

    发明人： Tsutomu Katsuki ,  Bunnai Saito

    IPC分类号： C07F9/38 ,  C07F5/06 ,  C07C251/24 ,  C07C249/02

    CPC分类号： C07C251/24 ,  B01J31/1805 ,  B01J31/2213 ,  B01J2231/30 ,  B01J2531/0252 ,  B01J2531/31 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/4006

    摘要： The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I′), (II) and (II′): [wherein R1s are each alkyl group or aryl group independently; R2s are each alkyl group or aryl group independently; R3s are each alkyl group or aryl group independently, and two R3s may bond with each other to form a ring; R4s are each hydrogen atom, halogen atom, alkyl group, alkoxy group, nitro group, or cyano group independently; R5 is alkyl group; and X1 is halogen atom, alkyl group, alkoxy group, acetoxy group or toluenesulfonyloxy group] is used as a catalyst to asymmetrically hydrophosphonylate an aldehyde with phosphonic acid or its derivatives.

    摘要翻译： 本发明涉及一种能够不仅对于芳族醛而且对于脂族醛产生具有足够高的对映体选择性的光学活性的α-羟基膦酸及其衍生物的制造方法，更具体地说，涉及一种制备光学活性的α-羟基膦酸 酸及其衍生物，其特征在于由下式（I），（I'），（II）和（II'）中的任何一种表示的光学活性铝（salalen）络合物：[其中R 1各自为烷基或 芳基独立; R2各自独立地为烷基或芳基; R3各自独立地为烷基或芳基，两个R 3可以彼此键合形成环; R4各自独立地为氢原子，卤素原子，烷基，烷氧基，硝基或氰基; R5是烷基; X 1为卤素原子，烷基，烷氧基，乙酰氧基或甲苯磺酰氧基]作为催化剂，用膦酸或其衍生物不对称地使膦酸化为醛。